From Conventional to Unusual Enzyme Inhibitor Scaffolds: The Quest for Target Specificity

Natural Products as Chemical Probes

(2010) Erin E. Carlson   ACS Chemical Biology

Targeted covalent drugs of the kinase family

(2010) Juswinder Singh et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

(Arene)Ru(II) complexes of epidermal growth factor receptor inhibiting tyrphostins with enhanced selectivity and cytotoxicity in cancer cells

(2010) B. Biersack et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cysteine proteases as targets for metal-based drugs

(2010) Simon P. Fricker   Metallomics

On the potential of natural products in the discovery of pharma leads: A case for reassessment

(2010) Samuel Danishefsky   NATURAL PRODUCT REPORTS

The art of the chemical probe

(2010) Stephen V Frye   Nature Chemical Biology

Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

(2010) P. A. Clemons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting proteins with metal complexes

(2009) Eric Meggers   CHEMICAL COMMUNICATIONS

New Protein Kinase CK2 Inhibitors: Jumping out of the Catalytic Box

(2009) Renaud Prudent et al.   CHEMISTRY & BIOLOGY

Supramolecular interactions between functional metal complexes and proteins

(2009) Catherine L. Davies et al.   DALTON TRANSACTIONS

Covalent Modifiers: An Orthogonal Approach to Drug Design

(2009) Michele H. Potashman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design of HIV Protease Inhibitors Based on Inorganic Polyhedral Metallacarboranes

(2009) Pavlína Řezáčová et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis at the Interface of Chemistry and Biology

(2009) Xu Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecularly Imprinted Microgels as Enzyme Inhibitors

(2009) Arnaud Cutivet et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A crowdsourcing evaluation of the NIH chemical probes

(2009) Tudor I Oprea et al.   Nature Chemical Biology

Identification of Polyoxometalates as Nanomolar Noncompetitive Inhibitors of Protein Kinase CK2

(2008) Renaud Prudent et al.   CHEMISTRY & BIOLOGY

Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones

(2008) John Spencer et al.   DALTON TRANSACTIONS

Inorganic Polyhedral Metallacarborane Inhibitors of HIV Protease: A New Approach to Overcoming Antiviral Resistance

(2008) Milan Kožíšek et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes

(2008) Jasna Maksimoska et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY