Argonaute proteins: functional insights and emerging roles

Two new and distinct roles for Drosophila Argonaute-2 in the nucleus: alternative pre-mRNA splicing and transcriptional repression

(2013) J. M. Taliaferro et al.   GENES & DEVELOPMENT

CapSeq and CIP-TAP Identify Pol II Start Sites and Reveal Capped Small RNAs as C. elegans piRNA Precursors

(2012) Weifeng Gu et al.   CELL

A Role for Small RNAs in DNA Double-Strand Break Repair

(2012) Wei Wei et al.   CELL

The Structure of Human Argonaute-2 in Complex with miR-20a

(2012) Elad Elkayam et al.   CELL

AGO4 Regulates Entry into Meiosis and Influences Silencing of Sex Chromosomes in the Male Mouse Germline

(2012) Andrew J. Modzelewski et al.   DEVELOPMENTAL CELL

Cytoplasmic Arabidopsis AGO7 accumulates in membrane-associated siRNA bodies and is required for ta-siRNA biogenesis

(2012) Virginie Jouannet et al.   EMBO JOURNAL

ArabidopsisArgonaute MID domains use their nucleotide specificity loop to sort small RNAs

(2012) Filipp Frank et al.   EMBO JOURNAL

microRNA-independent recruitment of Argonaute 1 to nanos mRNA through the Smaug RNA-binding protein

(2012) Benjamin D Pinder et al.   EMBO REPORTS

Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells

(2012) Julien Béthune et al.   EMBO REPORTS

Pumilio facilitates miRNA regulation of the E2F3 oncogene

(2012) W. O. Miles et al.   GENES & DEVELOPMENT

Quantitative functions of Argonaute proteins in mammalian development

(2012) D. Wang et al.   GENES & DEVELOPMENT

Dicer-dependent and -independent Argonaute2 Protein Interaction Networks in Mammalian Cells

(2012) Anne Frohn et al.   MOLECULAR & CELLULAR PROTEOMICS

The Cochaperone Shutdown Defines a Group of Biogenesis Factors Essential for All piRNA Populations in Drosophila

(2012) Daniel Olivieri et al.   MOLECULAR CELL

A Role for Fkbp6 and the Chaperone Machinery in piRNA Amplification and Transposon Silencing

(2012) Jordi Xiol et al.   MOLECULAR CELL

Precursor MicroRNA-Programmed Silencing Complex Assembly Pathways in Mammals

(2012) Xuhang Liu et al.   MOLECULAR CELL

Structure of yeast Argonaute with guide RNA

(2012) Kotaro Nakanishi et al.   NATURE

Structure and function of Zucchini endoribonuclease in piRNA biogenesis

(2012) Hiroshi Nishimasu et al.   NATURE

A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality

(2012) Bethany A. Buckley et al.   NATURE

The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis

(2012) Jonathan J. Ipsaro et al.   NATURE

Site-specific DICER and DROSHA RNA products control the DNA-damage response

(2012) Sofia Francia et al.   NATURE

Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells

(2012) Moussa Benhamed et al.   NATURE CELL BIOLOGY

Selective autophagy degrades DICER and AGO2 and regulates miRNA activity

(2012) Derrick Gibbings et al.   NATURE CELL BIOLOGY

Argonaute proteins couple chromatin silencing to alternative splicing

(2012) Maya Ameyar-Zazoua et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DICER- and AGO3-dependent generation of retinoic acid–induced DR2 Alu RNAs regulates human stem cell proliferation

(2012) QiDong Hu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The N domain of Argonaute drives duplex unwinding during RISC assembly

(2012) Pieter Bas Kwak et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding

(2012) Francesca Moretti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A conserved PUF–Ago–eEF1A complex attenuates translation elongation

(2012) Kyle Friend et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A small RNA response at DNA ends in Drosophila

(2012) Katharina M. Michalik et al.   NUCLEIC ACIDS RESEARCH

The slicing activity of miRNA-specific Argonautes is essential for the miRNA pathway in C. elegans

(2012) Samir Bouasker et al.   NUCLEIC ACIDS RESEARCH

The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets

(2012) Eric Huntzinger et al.   NUCLEIC ACIDS RESEARCH

microRNAs associated with the different human Argonaute proteins

(2012) A. Dueck et al.   NUCLEIC ACIDS RESEARCH

The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function

(2012) Inga Loedige et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of the primary piRNA biogenesis factor Zucchini reveals similarity to the bacterial PLD endonuclease Nuc

(2012) F. Voigt et al.   RNA

Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus

(2012) K. Nishi et al.   RNA

shutdown is a component of the Drosophila piRNA biogenesis machinery

(2012) J. B. Preall et al.   RNA

miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

(2012) S. Djuranovic et al.   SCIENCE

Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish

(2012) A. A. Bazzini et al.   SCIENCE

The Crystal Structure of Human Argonaute2

(2012) N. T. Schirle et al.   SCIENCE

Mirtrons: microRNA biogenesis via splicing

(2011) Jakub O. Westholm et al.   BIOCHIMIE

Arabidopsis Argonaute10 Specifically Sequesters miR166/165 to Regulate Shoot Apical Meristem Development

(2011) Hongliang Zhu et al.   CELL

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

(2011) Leonardo Salmena et al.   CELL

Multiple roles for small RNAs during plant reproduction

(2011) Frédéric Van Ex et al.   CURRENT OPINION IN PLANT BIOLOGY

Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila

(2011) A. L. Zamparini et al.   DEVELOPMENT

The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans

(2011) Guillaume Jannot et al.   EMBO REPORTS

RNAi-independent role for Argonaute2 in CTCF/CP190 chromatin insulator function

(2011) N. Moshkovich et al.   GENES & DEVELOPMENT

siRNA Repositioning for Guide Strand Selection by Human Dicer Complexes

(2011) Cameron L. Noland et al.   MOLECULAR CELL

GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets

(2011) Joerg E. Braun et al.   MOLECULAR CELL

Heterotypic piRNA Ping-Pong Requires Qin, a Protein with Both E3 Ligase and Tudor Domains

(2011) Zhao Zhang et al.   MOLECULAR CELL

Mammalian hyperplastic discs Homolog EDD Regulates miRNA-Mediated Gene Silencing

(2011) Hong Su et al.   MOLECULAR CELL

Poly(ADP-Ribose) Regulates Stress Responses and MicroRNA Activity in the Cytoplasm

(2011) Anthony K.L. Leung et al.   MOLECULAR CELL

Chromatin-associated RNA interference components contribute to transcriptional regulation in Drosophila

(2011) Filippo M. Cernilogar et al.   NATURE

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

(2011) Eric Huntzinger et al.   NATURE REVIEWS GENETICS

PIWI-interacting small RNAs: the vanguard of genome defence

(2011) Mikiko C. Siomi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of C3PO and mechanism of human RISC activation

(2011) Xuecheng Ye et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4–NOT

(2011) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs

(2011) Anthony K L Leung et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miRNA repression involves GW182-mediated recruitment of CCR4–NOT through conserved W-containing motifs

(2011) Marina Chekulaeva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

AGO6 Functions in RNA-Mediated Transcriptional Gene Silencing in Shoot and Root Meristems in Arabidopsis thaliana

(2011) Changho Eun et al.   PLoS One

Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis

(2011) T. Tanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes

(2011) S. Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deep-sequencing of human Argonaute-associated small RNAs provides insight into miRNA sorting and reveals Argonaute association with RNA fragments of diverse origin

(2011) Alexander Maxwell Burroughs et al.   RNA Biology

Increased siRNA duplex stability correlates with reduced off-target and elevated on-target effects

(2011) S. Petri et al.   RNA

Recognition of 2′-O-Methylated 3′-End of piRNA by the PAZ Domain of a Piwi Protein

(2011) Bernd Simon et al.   STRUCTURE

RNAi-dependent formation of heterochromatin and its diverse functions

(2010) Shiv IS Grewal   CURRENT OPINION IN GENETICS & DEVELOPMENT

How does the Royal Family of Tudor rule the PIWI-interacting RNA pathway?

(2010) M. C. Siomi et al.   GENES & DEVELOPMENT

Probing the initiation and effector phases of the somatic piRNA pathway in Drosophila

(2010) A. D. Haase et al.   GENES & DEVELOPMENT

HSP90 Protein Stabilizes Unloaded Argonaute Complexes and Microscopic P-bodies in Human Cells

(2010) Michael Johnston et al.   MOLECULAR BIOLOGY OF THE CELL

Hsc70/Hsp90 Chaperone Machinery Mediates ATP-Dependent RISC Loading of Small RNA Duplexes

(2010) Shintaro Iwasaki et al.   MOLECULAR CELL

In Vitro Assembly of Plant RNA-Induced Silencing Complexes Facilitated by Molecular Chaperone HSP90

(2010) Taichiro Iki et al.   MOLECULAR CELL

Small regulatory RNAs inhibit RNA polymerase II during the elongation phase of transcription

(2010) Shouhong Guang et al.   NATURE

Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

(2010) Filipp Frank et al.   NATURE

Control of female gamete formation by a small RNA pathway in Arabidopsis

(2010) Vianey Olmedo-Monfil et al.   NATURE

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis

(2010) Sihem Cheloufi et al.   NATURE

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

Small RNA sorting: matchmaking for Argonautes

(2010) Benjamin Czech et al.   NATURE REVIEWS GENETICS

Phosphorylation of human Argonaute proteins affects small RNA binding

(2010) Sabine Rüdel et al.   NUCLEIC ACIDS RESEARCH

Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter

(2010) Yongjun Chu et al.   NUCLEIC ACIDS RESEARCH

LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing

(2010) Victoria James et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway

(2010) K. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs

(2010) R. J. A. Frost et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins

(2010) S. L. Ameres et al.   RNA

A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity

(2010) D. Cifuentes et al.   SCIENCE

nhl-2 Modulates MicroRNA Activity in Caenorhabditis elegans

(2009) Christopher M. Hammell et al.   CELL

Small RNAs as Guardians of the Genome

(2009) Colin D. Malone et al.   CELL

Importin 8 Is a Gene Silencing Factor that Targets Argonaute Proteins to Distinct mRNAs

(2009) Lasse Weinmann et al.   CELL

The TRIM-NHL Protein TRIM32 Activates MicroRNAs and Prevents Self-Renewal in Mouse Neural Progenitors

(2009) Jens C. Schwamborn et al.   CELL

Origin, Biogenesis, and Activity of Plant MicroRNAs

(2009) Olivier Voinnet   CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

RNA-mediated chromatin-based silencing in plants

(2009) Marjori Matzke et al.   CURRENT OPINION IN CELL BIOLOGY

Human UPF1 Participates in Small RNA-Induced mRNA Downregulation

(2009) H. Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

The Silencing Domain of GW182 Interacts with PABPC1 To Promote Translational Repression and Degradation of MicroRNA Targets and Is Required for Target Release

(2009) L. Zekri et al.   MOLECULAR AND CELLULAR BIOLOGY

Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation

(2009) Marc R. Fabian et al.   MOLECULAR CELL

Distinct Mechanisms for MicroRNA Strand Selection by Drosophila Argonautes

(2009) Katsutomo Okamura et al.   MOLECULAR CELL

Hierarchical Rules for Argonaute Loading in Drosophila

(2009) Benjamin Czech et al.   MOLECULAR CELL

Active turnover modulates mature microRNA activity in Caenorhabditis elegans

(2009) Saibal Chatterjee et al.   NATURE

A three-dimensional view of the molecular machinery of RNA interference

(2009) Martin Jinek et al.   NATURE

Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability

(2009) Yohei Kirino et al.   NATURE CELL BIOLOGY

The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

(2009) Agnieszka Rybak et al.   NATURE CELL BIOLOGY

Control of alternative splicing through siRNA-mediated transcriptional gene silencing

(2009) Mariano Alló et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins

(2009) Bingbing Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNAi in Budding Yeast

(2009) I. A. Drinnenberg et al.   SCIENCE

C3PO, an Endoribonuclease That Promotes RNAi by Facilitating RISC Activation

(2009) Y. Liu et al.   SCIENCE

Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies

(2008) Yan Zeng et al.   BIOCHEMICAL JOURNAL

Sorting of Small RNAs into Arabidopsis Argonaute Complexes Is Directed by the 5′ Terminal Nucleotide

(2008) Shijun Mi et al.   CELL

Specificity of ARGONAUTE7-miR390 Interaction and Dual Functionality in TAS3 Trans-Acting siRNA Formation

(2008) Taiowa A. Montgomery et al.   CELL

Argonaute-2 Expression Is Regulated by Epidermal Growth Factor Receptor and Mitogen-Activated Protein Kinase Signaling and Correlates with a Transformed Phenotype in Breast Cancer Cells

(2008) Brian D. Adams et al.   ENDOCRINOLOGY

A Human snoRNA with MicroRNA-Like Functions

(2008) Christine Ender et al.   MOLECULAR CELL

Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells

(2008) Yoshinori Kawamura et al.   NATURE

The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs

(2008) Katsutomo Okamura et al.   NATURE

Prolyl 4-hydroxylation regulates Argonaute 2 stability

(2008) Hank H. Qi et al.   NATURE

Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes

(2008) Toshiaki Watanabe et al.   NATURE

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

(2008) Oliver H. Tam et al.   NATURE

An endogenous small interfering RNA pathway in Drosophila

(2008) Benjamin Czech et al.   NATURE

Antisense transcripts are targets for activating small RNAs

(2008) Jacob C Schwartz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A multifunctional human Argonaute2-specific monoclonal antibody

(2008) S. Rudel et al.   RNA

Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs

(2008) M. Landthaler et al.   RNA

An Argonaute Transports siRNAs from the Cytoplasm to the Nucleus

(2008) S. Guang et al.   SCIENCE

Argonaute proteins: key players in RNA silencing

(2007) Gyorgy Hutvagner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY