From guide to target: molecular insights into eukaryotic RNA-interference machinery

RNA Clamping by Vasa Assembles a piRNA Amplifier Complex on Transposon Transcripts

(2014) Jordi Xiol et al.   CELL

The Rhino-Deadlock-Cutoff Complex Licenses Noncanonical Transcription of Dual-Strand piRNA Clusters in Drosophila

(2014) Fabio Mohn et al.   CELL

The HP1 Homolog Rhino Anchors a Nuclear Complex that Suppresses piRNA Precursor Splicing

(2014) Zhao Zhang et al.   CELL

A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer

(2014) Yuan Tian et al.   MOLECULAR CELL

A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing

(2014) Ying Chen et al.   MOLECULAR CELL

Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression

(2014) Hansruedi Mathys et al.   MOLECULAR CELL

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Generation of catalytic human Ago4 identifies structural elements important for RNA cleavage

(2014) Judith Hauptmann et al.   RNA

The MID-PIWI module of Piwi proteins specifies nucleotide- and strand-biases of piRNAs

(2014) E. Cora et al.   RNA

Structural basis for microRNA targeting

(2014) N. T. Schirle et al.   SCIENCE

Molecular Mechanisms of RNA Interference

(2013) Ross C. Wilson et al.   Annual Review of Biophysics

Beyond Secondary Structure: Primary-Sequence Determinants License Pri-miRNA Hairpins for Processing

(2013) Vincent C. Auyeung et al.   CELL

The piRNA pathway in flies: highlights and future directions

(2013) Paloma M Guzzardo et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation

(2013) Latifa Zekri et al.   EMBO JOURNAL

DmGTSF1 is necessary for Piwi-piRISC-mediated transcriptional transposon silencing in the Drosophila ovary

(2013) H. Ohtani et al.   GENES & DEVELOPMENT

Drosophila Gtsf1 is an essential component of the Piwi-mediated transcriptional silencing complex

(2013) D. Donertas et al.   GENES & DEVELOPMENT

The Role of miRNAs in Regulating Gene Expression Networks

(2013) Allan M. Gurtan et al.   JOURNAL OF MOLECULAR BIOLOGY

A Genome-wide RNAi Screen Draws a Genetic Framework for Transposon Control and Primary piRNA Biogenesis in Drosophila

(2013) Felix Muerdter et al.   MOLECULAR CELL

The Genetic Makeup of the Drosophila piRNA Pathway

(2013) Dominik Handler et al.   MOLECULAR CELL

A Transcriptome-wide RNAi Screen in the Drosophila Ovary Reveals Factors of the Germline piRNA Pathway

(2013) Benjamin Czech et al.   MOLECULAR CELL

RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond

(2013) Stephane E. Castel et al.   NATURE REVIEWS GENETICS

Argonaute proteins: functional insights and emerging roles

(2013) Gunter Meister   NATURE REVIEWS GENETICS

Homeostatic control of Argonaute stability by microRNA availability

(2013) Peter Smibert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Turning catalytically inactive human Argonaute proteins into active slicer enzymes

(2013) Judith Hauptmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular dissection of human Argonaute proteins by DNA shuffling

(2013) Nina Schürmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing

(2013) Ho Young Lee et al.   NUCLEIC ACIDS RESEARCH

miRBase: annotating high confidence microRNAs using deep sequencing data

(2013) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

Function of Piwi, a nuclear Piwi/Argonaute protein, is independent of its slicer activity

(2013) Nicole Darricarrère et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eukaryotic Argonautes come into focus

(2013) Claus-D. Kuhn et al.   TRENDS IN BIOCHEMICAL SCIENCES

Eukaryote-Specific Insertion Elements Control Human ARGONAUTE Slicer Activity

(2013) Kotaro Nakanishi et al.   Cell Reports

The Making of a Slicer: Activation of Human Argonaute-1

(2013) Christopher R. Faehnle et al.   Cell Reports

Transcriptional Silencing of Transposons by Piwi and Maelstrom and Its Impact on Chromatin State and Gene Expression

(2012) Grzegorz Sienski et al.   CELL

UAP56 Couples piRNA Clusters to the Perinuclear Transposon Silencing Machinery

(2012) Fan Zhang et al.   CELL

The Structure of Human Argonaute-2 in Complex with miR-20a

(2012) Elad Elkayam et al.   CELL

MicroRNA biogenesis: regulating the regulators

(2012) Emily F. Finnegan et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

ArabidopsisArgonaute MID domains use their nucleotide specificity loop to sort small RNAs

(2012) Filipp Frank et al.   EMBO JOURNAL

Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells

(2012) Julien Béthune et al.   EMBO REPORTS

Microprocessor dynamics and interactions at endogenous imprinted C19MC microRNA genes

(2012) C. Bellemer et al.   JOURNAL OF CELL SCIENCE

Coordinated Activities of Human Dicer Domains in Regulatory RNA Processing

(2012) Enbo Ma et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of yeast Argonaute with guide RNA

(2012) Kotaro Nakanishi et al.   NATURE

Structure and function of Zucchini endoribonuclease in piRNA biogenesis

(2012) Hiroshi Nishimasu et al.   NATURE

The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis

(2012) Jonathan J. Ipsaro et al.   NATURE

The molecular architecture of human Dicer

(2012) Pick-Wei Lau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC

(2012) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4–NOT deadenylase complex

(2012) Alain-Pierre Petit et al.   NUCLEIC ACIDS RESEARCH

Long-lived microRNA-Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses

(2012) S. H. Olejniczak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

(2012) S. Djuranovic et al.   SCIENCE

Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish

(2012) A. A. Bazzini et al.   SCIENCE

The Crystal Structure of Human Argonaute2

(2012) N. T. Schirle et al.   SCIENCE

Phospholipase D: Enzymology, Functionality, and Chemical Modulation

(2011) Paige E. Selvy et al.   CHEMICAL REVIEWS

The Cutoff protein regulates piRNA cluster expression and piRNA production in theDrosophilagermline

(2011) Attilio Pane et al.   EMBO JOURNAL

3′ End Formation of PIWI-Interacting RNAs In Vitro

(2011) Shinpei Kawaoka et al.   MOLECULAR CELL

GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets

(2011) Joerg E. Braun et al.   MOLECULAR CELL

Dicer recognizes the 5′ end of RNA for efficient and accurate processing

(2011) Jong-Eun Park et al.   NATURE

Deciphering arginine methylation: Tudor tells the tale

(2011) Chen Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of C3PO and mechanism of human RISC activation

(2011) Xuecheng Ye et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4–NOT

(2011) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miRNA repression involves GW182-mediated recruitment of CCR4–NOT through conserved W-containing motifs

(2011) Marina Chekulaeva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Drosophila Piwi functions downstream of piRNA production mediating a chromatin-based transposon silencing mechanism in female germ line

(2011) S. H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Argonaute proteins regulate microRNA stability: Increased microRNA abundance by Argonaute proteins is due to microRNA stabilization

(2011) Julia Winter et al.   RNA Biology

Production of artificial piRNAs in flies and mice

(2011) F. Muerdter et al.   RNA

Probing the initiation and effector phases of the somatic piRNA pathway in Drosophila

(2010) A. D. Haase et al.   GENES & DEVELOPMENT

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis

(2010) Sihem Cheloufi et al.   NATURE

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

Small RNA sorting: matchmaking for Argonautes

(2010) Benjamin Czech et al.   NATURE REVIEWS GENETICS

Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation

(2010) Martin Jinek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains

(2010) Y. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the dimerization domain of DiGeorge Critical Region 8

(2010) Rachel Senturia et al.   PROTEIN SCIENCE

Structures of the first and second double-stranded RNA-binding domains of human TAR RNA-binding protein

(2010) Seisuke Yamashita et al.   PROTEIN SCIENCE

DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures

(2010) M. Faller et al.   RNA

A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity

(2010) D. Cifuentes et al.   SCIENCE

Structure of Arabidopsis HYPONASTIC LEAVES1 and Its Molecular Implications for miRNA Processing

(2010) Seong Wook Yang et al.   STRUCTURE

Making RISC

(2010) Tomoko Kawamata et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Drosophila HP1 Homolog Rhino Is Required for Transposon Silencing and piRNA Production by Dual-Strand Clusters

(2009) Carla Klattenhoff et al.   CELL

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Structural insights into mechanisms of the small RNA methyltransferase HEN1

(2009) Ying Huang et al.   NATURE

Small silencing RNAs: an expanding universe

(2009) Megha Ghildiyal et al.   NATURE REVIEWS GENETICS

Structural insights into RNA processing by the human RISC-loading complex

(2009) Hong-Wei Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing

(2009) S. L. Lian et al.   RNA

C3PO, an Endoribonuclease That Promotes RNAi by Facilitating RISC Activation

(2009) Y. Liu et al.   SCIENCE

Small RNA guides for de novo DNA methylation in mammalian germ cells

(2008) A. A. Aravin et al.   GENES & DEVELOPMENT

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Mice

(2008) Alexei A. Aravin et al.   MOLECULAR CELL

Structural and biochemical insights into the dicing mechanism of mouse Dicer: A conserved lysine is critical for dsRNA cleavage

(2008) Z. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA