The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis
Authors
Keywords
-
Journal
Nature Communications
Volume 9, Issue 1, Pages -
Publisher
Springer Nature America, Inc
Online
2018-08-08
DOI
10.1038/s41467-018-05768-3
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Shp2 Plays a Critical Role in IL-6-Induced EMT in Breast Cancer Cells
- (2017) Xuan Sun et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Review: Frontiers of Antifibrotic Therapy in Systemic Sclerosis
- (2017) Jörg H. W. Distler et al. Arthritis & Rheumatology
- The transcription factor GLI2 as a downstream mediator of transforming growth factor-β-induced fibroblast activation in SSc
- (2016) Ruifang Liang et al. ANNALS OF THE RHEUMATIC DISEASES
- Myocardial fragmentation associated with disruption of the Z-band in hypertrophic cardiomyopathy in Noonan syndrome
- (2016) Hiroaki Kawano et al. CARDIOVASCULAR PATHOLOGY
- Macrophages in Tissue Repair, Regeneration, and Fibrosis
- (2016) Thomas A. Wynn et al. IMMUNITY
- Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus
- (2016) Jianxun Wang et al. JOURNAL OF CLINICAL INVESTIGATION
- Shp2 Deficiency Impairs the Inflammatory Response AgainstHaemophilus influenzaeby Regulating Macrophage Polarization
- (2016) Lifang Zhao et al. JOURNAL OF INFECTIOUS DISEASES
- Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
- (2016) Ying-Nan P. Chen et al. NATURE
- Update on macrophages and innate immunity in scleroderma
- (2015) Jennifer J. Chia et al. CURRENT OPINION IN RHEUMATOLOGY
- SHP2 sails from physiology to pathology
- (2015) Mylène Tajan et al. European Journal of Medical Genetics
- Fluorofenidone protects against renal fibrosis by inhibiting STAT3 tyrosine phosphorylation
- (2015) Juan Tang et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis
- (2015) Katrin Palumbo-Zerr et al. NATURE MEDICINE
- Inhibition of casein kinase II reduces TGFβ induced fibroblast activation and ameliorates experimental fibrosis
- (2014) Yun Zhang et al. ANNALS OF THE RHEUMATIC DISEASES
- Vitamin D receptor regulates TGF-β signalling in systemic sclerosis
- (2014) Pawel Zerr et al. ANNALS OF THE RHEUMATIC DISEASES
- Structure, Function, and Pathogenesis of SHP2 in Developmental Disorders and Tumorigenesis
- (2014) Wen-Qing Huang et al. CURRENT CANCER DRUG TARGETS
- SHP2 Positively Regulates TGFβ1-induced Epithelial-Mesenchymal Transition Modulated by Its Novel Interacting Protein Hook1
- (2014) Shuomin Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Myeloid-Specific Disruption of Tyrosine Phosphatase Shp2 Promotes Alternative Activation of Macrophages and Predisposes Mice to Pulmonary Fibrosis
- (2014) Bo Tao et al. JOURNAL OF IMMUNOLOGY
- Therapeutic Potential of Targeting the Oncogenic SHP2 Phosphatase
- (2014) Li-Fan Zeng et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis
- (2013) Clara Dees et al. ANNALS OF THE RHEUMATIC DISEASES
- Inactivation of urokinase-type plasminogen activator receptor (uPAR) gene induces dermal and pulmonary fibrosis and peripheral microvasculopathy in mice: a new model of experimental scleroderma?
- (2013) Mirko Manetti et al. ANNALS OF THE RHEUMATIC DISEASES
- 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative
- (2013) Frank van den Hoogen et al. ANNALS OF THE RHEUMATIC DISEASES
- Protein Tyrosine Phosphatase Expression Profile of Rheumatoid Arthritis Fibroblast-like Synoviocytes: A Novel Role of SH2 Domain-Containing Phosphatase 2 as a Modulator of Invasion and Survival
- (2013) Stephanie M. Stanford et al. ARTHRITIS AND RHEUMATISM
- The tyrosine phosphatase SHP-1 inhibits proliferation of activated hepatic stellate cells by impairing PDGF receptor signaling
- (2013) Elena Tibaldi et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis
- (2012) Clara Dees et al. ARTHRITIS AND RHEUMATISM
- Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease
- (2012) P. Zerr et al. BLOOD
- Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop
- (2012) Nicola Aceto et al. NATURE MEDICINE
- Experimental determination ofPhilodendron melinoniiandArabidopsis thalianatissue microstructure and geometric modeling via finite-edge centroidal Voronoi tessellation
- (2012) Tanvir R. Faisal et al. PHYSICAL REVIEW E
- The Fra-2 transgenic mouse model of systemic sclerosis
- (2012) Britta Maurer et al. VASCULAR PHARMACOLOGY
- Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis
- (2012) Alfiya Akhmetshina et al. Nature Communications
- Phase I Dose Escalation Study of Sodium Stibogluconate (SSG), a Protein Tyrosine Phosphatase Inhibitor, Combined with Interferon Alpha for Patients with Solid Tumors
- (2012) Aung Naing et al. Journal of Cancer
- Platelet-derived serotonin links vascular disease and tissue fibrosis
- (2011) Clara Dees et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Protein Tyrosine Phosphatase SHP-2 Is Positively Involved in Platelet-Derived Growth Factor–Signaling in Vascular Neointima Formation via the Reactive Oxygen Species–Related Pathway
- (2011) Kyung-Jong Won et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Single- and two-phase flow in microfluidic porous media analogs based on Voronoi tessellation
- (2011) Mengjie Wu et al. LAB ON A CHIP
- Phosphatase-Dependent and -Independent Functions of Shp2 in Neural Crest Cells Underlie LEOPARD Syndrome Pathogenesis
- (2010) Rodney A. Stewart et al. DEVELOPMENTAL CELL
- Angiotensin-II-induced apoptosis requires regulation of nucleolin and Bcl-xL by SHP-2 in primary lung endothelial cells
- (2010) Y. H. Lee et al. JOURNAL OF CELL SCIENCE
- Scleroderma
- (2009) Armando Gabrielli et al. NEW ENGLAND JOURNAL OF MEDICINE
- Wound repair and regeneration
- (2008) Geoffrey C. Gurtner et al. NATURE
- Leopard syndrome
- (2008) Anna Sarkozy et al. Orphanet Journal of Rare Diseases
- Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking
- (2008) K. Hellmuth et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cellular and molecular mechanisms of fibrosis
- (2007) TA Wynn JOURNAL OF PATHOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now