Shp2 Plays a Critical Role in IL-6-Induced EMT in Breast Cancer Cells

IL-6 Overexpression in ERG-Positive Prostate Cancer Is Mediated by Prostaglandin Receptor EP2

(2016) Constanze Merz et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-1β induces IL-6 production and increases invasiveness and estrogen-independent growth in a TG2-dependent manner in human breast cancer cells

(2016) Keunhee Oh et al.   BMC CANCER

SHP2 and UGP2 are Biomarkers for Progression and Poor Prognosis of Gallbladder Cancer

(2016) Qunwei Wang et al.   CANCER INVESTIGATION

Cancer development, chemoresistance, epithelial to mesenchymal transition and stem cells: A snapshot of IL-6 mediated involvement

(2016) Rashmi Bharti et al.   CANCER LETTERS

WSTF promotes proliferation and invasion of lung cancer cells by inducing EMT via PI3K/Akt and IL-6/STAT3 signaling pathways

(2016) Jin Meng et al.   CELLULAR SIGNALLING

Gain-of-function mutations ofPtpn11(Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies

(2016) Xia Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel double-negative feedback loop between miR-489 and the HER2-SHP2-MAPK signaling axis regulates breast cancer cell proliferation and tumor growth

(2016) Yogin Patel et al.   Oncotarget

RING1B contributes to Ewing sarcoma development by repressing the NaV1.6 sodium channel and the NF-κB pathway, independently of the fusion oncoprotein

(2016) Inmaculada Hernandez-Muñoz et al.   Oncotarget

Hormonal-receptor positive breast cancer: IL-6 augments invasion and lymph node metastasis via stimulating cathepsin B expression

(2016) Sherif A. Ibrahim et al.   Journal of Advanced Research

Blocking IL-6 trans-Signaling Prevents High-Fat Diet-Induced Adipose Tissue Macrophage Recruitment but Does Not Improve Insulin Resistance

(2015) Michael J. Kraakman et al.   Cell Metabolism

Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity

(2015) Brian T. Burmeister et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGF augments TGF -induced epithelial-mesenchymal transition by promoting SHP2 binding to GAB1

(2015) J. M. Buonato et al.   JOURNAL OF CELL SCIENCE

Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition

(2015) K Zhang et al.   ONCOGENE

Expression and prognosis value of SHP2 in patients with pancreatic ductal adenocarcinoma

(2015) Jiawei Zheng et al.   TUMOR BIOLOGY

IL-6 originated from breast cancer tissue-derived mesenchymal stromal cells may contribute to carcinogenesis

(2015) Özlem Sağlam et al.   TUMOR BIOLOGY

Inhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma

(2015) Valentina E. Schneeberger et al.   Oncotarget

Different Associations of CD45 Isoforms with STAT3, PKC and ERK Regulate IL-6-Induced Proliferation in Myeloma

(2015) Xu Zheng et al.   PLoS One

Src-homology 2 domain-containing tyrosine phosphatase 2 promotes oral cancer invasion and metastasis

(2014) Hsueh-Chun Wang et al.   BMC CANCER

Structure, Function, and Pathogenesis of SHP2 in Developmental Disorders and Tumorigenesis

(2014) Wen-Qing Huang et al.   CURRENT CANCER DRUG TARGETS

SHP2 Positively Regulates TGFβ1-induced Epithelial-Mesenchymal Transition Modulated by Its Novel Interacting Protein Hook1

(2014) Shuomin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of interleukin-6 is associated with epithelial-mesenchymal transition and survival rates in gallbladder cancer

(2014) MINGDI ZHANG et al.   Molecular Medicine Reports

Chronic Inflammation and Cytokines in the Tumor Microenvironment

(2014) Glauben Landskron et al.   Journal of Immunology Research

IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro

(2013) Shoichi Kaneshiro et al.   JOURNAL OF BONE AND MINERAL METABOLISM

The Tyrosine Phosphatase SHP2 Regulates Focal Adhesion Kinase to Promote EGF-Induced Lamellipodia Persistence and Cell Migration

(2013) Zachary R. Hartman et al.   MOLECULAR CANCER RESEARCH

Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase

(2013) K Miura et al.   ONCOGENE

Upregulation of Src homology phosphotyrosyl phosphatase 2 (Shp2) expression in oral cancer and knockdown of Shp2 expression inhibit tumor cell viability and invasion in vitro

(2013) Hongjun Xie et al.   Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Atypical Protein Kinase C Phosphorylates Par6 and Facilitates Transforming Growth Factor  -Induced Epithelial-to-Mesenchymal Transition

(2012) A. Gunaratne et al.   MOLECULAR AND CELLULAR BIOLOGY

Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop

(2012) Nicola Aceto et al.   NATURE MEDICINE

IL-6 Promotes Head and Neck Tumor Metastasis by Inducing Epithelial-Mesenchymal Transition via the JAK-STAT3-SNAIL Signaling Pathway

(2011) A. Yadav et al.   MOLECULAR CANCER RESEARCH

IL-6 increases B-cell IgG production in a feed-forward proinflammatory mechanism to skew hematopoiesis and elevate myeloid production

(2010) K. Maeda et al.   BLOOD

Anxa2 Plays a Critical Role in Enhanced Invasiveness of the Multidrug Resistant Human Breast Cancer Cells

(2009) Fei Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells

(2009) N J Sullivan et al.   ONCOGENE

Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells

(2009) M Walter et al.   ONCOGENE

The tyrosine phosphatase Shp2 (PTPN11) in cancer

(2008) Gordon Chan et al.   CANCER AND METASTASIS REVIEWS

Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells

(2008) X-D Zhou et al.   CELL DEATH AND DIFFERENTIATION