Vitamin D receptor regulates TGF-β signalling in systemic sclerosis

THU0057 Inhibition of Heat Shock Protein 90 (Hsp90) Prevents Fibrosis by Targeting Canonical TGF-B Signaling

(2014) M. Tomcik et al.   ANNALS OF THE RHEUMATIC DISEASES

Activation of pregnane X receptor inhibits experimental dermal fibrosis

(2013) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis

(2013) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Further emergent evidence for the vitamin D endocrine system involvement in autoimmune rheumatic disease risk and prognosis

(2013) Maurizio Cutolo   ANNALS OF THE RHEUMATIC DISEASES

A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response

(2013) Ning Ding et al.   CELL

20S-Hydroxyvitamin D3, Noncalcemic Product of CYP11A1 Action on Vitamin D3, Exhibits Potent Antifibrogenic Activity in Vivo

(2013) Andrzej Slominski et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A nonclassical vitamin D receptor pathway suppresses renal fibrosis

(2013) Ichiaki Ito et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of sumoylation prevents experimental fibrosis

(2012) Aisa Khodzhigorova et al.   ANNALS OF THE RHEUMATIC DISEASES

Stimulation of soluble guanylate cyclase reduces experimental dermal fibrosis

(2012) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis

(2012) Gerhard Krönke et al.   ANNALS OF THE RHEUMATIC DISEASES

Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis

(2012) Nicole Reich et al.   ANNALS OF THE RHEUMATIC DISEASES

Pomalidomide is effective for prevention and treatment of experimental skin fibrosis

(2012) Simon Weingärtner et al.   ANNALS OF THE RHEUMATIC DISEASES

β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis

(2012) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis

(2012) Marlene Krämer et al.   ANNALS OF THE RHEUMATIC DISEASES

Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis

(2012) Angelika Horn et al.   ARTHRITIS AND RHEUMATISM

JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis

(2012) Clara Dees et al.   ARTHRITIS AND RHEUMATISM

Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease

(2012) P. Zerr et al.   BLOOD

Innovative antifibrotic therapies in systemic sclerosis

(2012) Christian Beyer et al.   CURRENT OPINION IN RHEUMATOLOGY

New vitamin D analogs as potential therapeutics in melanoma

(2012) Paulina Szyszka et al.   Expert Review of Anticancer Therapy

Increased risk of osteoporosis and fracture in women with systemic sclerosis: A comparative study with rheumatoid arthritis

(2012) Jérôme Avouac et al.   ARTHRITIS CARE & RESEARCH

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

(2012) Alfiya Akhmetshina et al.   Nature Communications

The transcription factor JunD mediates transforming growth factor  -induced fibroblast activation and fibrosis in systemic sclerosis

(2011) K. Palumbo et al.   ANNALS OF THE RHEUMATIC DISEASES

Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis

(2011) C. Dees et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of glycogen synthase kinase 3  induces dermal fibrosis by activation of the canonical Wnt pathway

(2011) C. Bergmann et al.   ANNALS OF THE RHEUMATIC DISEASES

Serum 25-OH vitamin D concentrations are linked with various clinical aspects in patients with systemic sclerosis: A retrospective cohort study and review of the literature

(2011) Yoav Arnson et al.   AUTOIMMUNITY REVIEWS

Vitamin D and its emerging role in immunopathology

(2011) Muhammad Haroon et al.   CLINICAL RHEUMATOLOGY

Platelet-derived serotonin links vascular disease and tissue fibrosis

(2011) Clara Dees et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recent insights into vitamin D and its receptor

(2011) Piergiorgio Messa et al.   JOURNAL OF NEPHROLOGY

Significantly Decreased Serum 25-Hydroxyvitamin D Levels in a Large German Systemic Sclerosis Cohort

(2011) T. GAMBICHLER et al.   JOURNAL OF RHEUMATOLOGY

Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis

(2010) Sieglinde Marquart et al.   ARTHRITIS AND RHEUMATISM

Animal models of systemic sclerosis: Prospects and limitations

(2010) Christian Beyer et al.   ARTHRITIS AND RHEUMATISM

Decreased lymphatic vessel counts in patients with systemic sclerosis: Association with fingertip ulcers

(2010) Alfiya Akhmetshina et al.   ARTHRITIS AND RHEUMATISM

Very low levels of vitamin D in systemic sclerosis patients

(2010) Paola Caramaschi et al.   CLINICAL RHEUMATOLOGY

Vitamin D in systemic sclerosis

(2010) Laura Belloli et al.   CLINICAL RHEUMATOLOGY

Vitamin D Deficiency in a Cohort of Patients with Systemic Scleroderma from the South of Spain

(2010) R. R. FERNANDEZ et al.   JOURNAL OF RHEUMATOLOGY

Vitamin D Receptor Attenuates Renal Fibrosis by Suppressing the Renin-Angiotensin System

(2010) Y. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Low bone mass in juvenile onset sclerosis systemic: the possible role for 25-hydroxyvitamin D insufficiency

(2010) Samuel Katsuyuki Shinjo et al.   RHEUMATOLOGY INTERNATIONAL

EULAR recommendations for the treatment of systemic sclerosis: a report from the EULAR Scleroderma Trials and Research group (EUSTAR)

(2009) O Kowal-Bielecka et al.   ANNALS OF THE RHEUMATIC DISEASES

Hypovitaminosis D in Systemic Sclerosis

(2009) G. CALZOLARI et al.   JOURNAL OF RHEUMATOLOGY

Vitamin D Deficiency and Insufficiency in 2 Independent Cohorts of Patients with Systemic Sclerosis

(2009) A. VACCA et al.   JOURNAL OF RHEUMATOLOGY

Scleroderma

(2009) Armando Gabrielli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts

(2008) Alfiya Akhmetshina et al.   ARTHRITIS AND RHEUMATISM