Heat shock response and autophagy—cooperation and control

Autophagy activation by NFκB is essential for cell survival after heat shock

(2014) Mathieu Nivon et al.   Autophagy

Nuclear transcription factor κ B activation and protein turnover adaptations in skeletal muscle of patients with progressive stages of lung cancer cachexia

(2013) Céline M Op den Kamp et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Autophagic Degradation Contributes to Muscle Wasting in Cancer Cachexia

(2013) Fabio Penna et al.   AMERICAN JOURNAL OF PATHOLOGY

Title efficacy of phosphodiesterase 5 inhibitor on distant burn-induced muscle autophagy, microcirculation, and survival rate

(2013) Sachiko Hosokawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Exercise restores decreased physical activity levels and increases markers of autophagy and oxidative capacity in myostatin/activin-blocked mdx mice

(2013) Juha J. Hulmi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Higher activation of autophagy in skeletal muscle of mice during endurance exercise in the fasted state

(2013) Cécile Jamart et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Ginsenoside Rg3 improves cardiac mitochondrial population quality: Mimetic exercise training

(2013) Mengwei Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Physical exercise improves functional recovery through mitigation of autophagy, attenuation of apoptosis and enhancement of neurogenesis after MCAO in rats

(2013) Liying Zhang et al.   BMC NEUROSCIENCE

Nandrolone attenuates aortic adaptation to exercise in rats

(2013) Mengwei Sun et al.   CARDIOVASCULAR RESEARCH

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Mild eccentric exercise increases Hsp72 content in skeletal muscles from adult and late middle-aged rats

(2013) Evan J. H. Lewis et al.   CELL STRESS & CHAPERONES

Exercise reduces cellular stress related to skeletal muscle insulin resistance

(2013) Mariana Aguiar de Matos et al.   CELL STRESS & CHAPERONES

Heme oxygenase-1 aggravates heat stress-induced neuronal injury and decreases autophagy in cerebellar Purkinje cells of rats

(2013) Chuan-Wang Li et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats

(2013) Li Luo et al.   EXPERIMENTAL GERONTOLOGY

Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance

(2013) Vitor A. Lira et al.   FASEB JOURNAL

Acute environmental hypoxia induces LC3 lipidation in a genotype-dependent manner

(2013) Evi Masschelein et al.   FASEB JOURNAL

Attenuating heat-induced cellular autophagy, apoptosis and damage in H9c2 cardiomyocytes by pre-inducing HSP70 with heat shock preconditioning

(2013) Shu-Fen Hsu et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Doxorubicin-induced markers of myocardial autophagic signaling in sedentary and exercise trained animals

(2013) Ashley J. Smuder et al.   JOURNAL OF APPLIED PHYSIOLOGY

Heat Shock Factor 1 (HSF1) Controls Chemoresistance and Autophagy through Transcriptional Regulation of Autophagy-related Protein 7 (ATG7)

(2013) Shruti Desai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulatory Coordination between Two Major Intracellular Homeostatic Systems

(2013) Karol Dokladny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mechanism and Physiological Function of Macroautophagy

(2013) Daniel J. Klionsky et al.   Journal of Innate Immunity

Autophagic response to exercise training in skeletal muscle with age

(2013) Yong An Kim et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

The molecular mechanism and potential role of heat shock-induced p53 protein accumulation

(2013) Juqiang Han et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy

(2013) Estelle Woldt et al.   NATURE MEDICINE

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exercise, GLUT4, and Skeletal Muscle Glucose Uptake

(2013) Erik A. Richter et al.   PHYSIOLOGICAL REVIEWS

Exercise Training Reverses Skeletal Muscle Atrophy in an Experimental Model of VCP Disease

(2013) Angèle Nalbandian et al.   PLoS One

Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy

(2013) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Autophagy in Parkinson's Disease

(2013) M. A. Lynch-Day et al.   Cold Spring Harbor Perspectives in Medicine

Hypoxia-mediated prior induction of monocyte-expressed HSP72 and HSP32 provides protection to the disturbances to redox balance associated with human sub-maximal aerobic exercise

(2012) Lee Taylor et al.   AMINO ACIDS

Exercise induces autophagy in peripheral tissues and in the brain

(2012) Congcong He et al.   Autophagy

Acute heat stress prior to downhill running may enhance skeletal muscle remodeling

(2012) Chad D. Touchberry et al.   CELL STRESS & CHAPERONES

Bortezomib/proteasome inhibitor triggers both apoptosis and autophagy-dependent pathways in melanoma cells

(2012) Denis Selimovic et al.   CELLULAR SIGNALLING

The physiological stress response to high-intensity sprint exercise following the ingestion of sodium bicarbonate

(2012) Daniel J. Peart et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Myocardial accumulation and localization of the inducible 70-kDa heat shock protein, Hsp70, following exercise

(2012) K. J. Milne et al.   JOURNAL OF APPLIED PHYSIOLOGY

Modulation of autophagy and ubiquitin-proteasome pathways during ultra-endurance running

(2012) Cécile Jamart et al.   JOURNAL OF APPLIED PHYSIOLOGY

Matched work high-intensity interval and continuous running induce similar increases in PGC-1α mRNA, AMPK, p38, and p53 phosphorylation in human skeletal muscle

(2012) Jonathan D. Bartlett et al.   JOURNAL OF APPLIED PHYSIOLOGY

Role of autophagy in COPD skeletal muscle dysfunction

(2012) Sabah N. A. Hussain et al.   JOURNAL OF APPLIED PHYSIOLOGY

NF- B regulates protein quality control after heat stress through modulation of the BAG3-HspB8 complex

(2012) M. Nivon et al.   JOURNAL OF CELL SCIENCE

Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease

(2012) Anson Pierce et al.   JOURNAL OF NEUROCHEMISTRY

Skeletal Muscle Autophagy and Protein Breakdown Following Resistance Exercise are Similar in Younger and Older Adults

(2012) C. S. Fry et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Combination of Pan-Histone Deacetylase Inhibitor and Autophagy Inhibitor Exerts Superior Efficacy against Triple-Negative Human Breast Cancer Cells

(2012) R. Rao et al.   MOLECULAR CANCER THERAPEUTICS

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

(2012) Congcong He et al.   NATURE

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Autophagy and Apoptosis Act as Partners to Induce Germ Cell Death after Heat Stress in Mice

(2012) Mianqiu Zhang et al.   PLoS One

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

Regulation of autophagy by nucleoporin Tpr

(2012) Tatsuyoshi Funasaka et al.   Scientific Reports

Effects of hypoxia on muscle protein synthesis and anabolic signaling at rest and in response to acute resistance exercise

(2011) Timothy Etheridge et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Thermotolerance and heat acclimation may share a common mechanism in humans

(2011) Matthew Kuennen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Exercise-induced dehydration with and without environmental heat stress results in increased oxidative stress

(2011) Angela R. Hillman et al.   Applied Physiology Nutrition and Metabolism

Activation of autophagy is required for muscle homeostasis during physical exercise

(2011) Usha Nair et al.   Autophagy

AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation

(2011) Libin Shang et al.   Autophagy

Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles

(2011) Paolo Grumati et al.   Autophagy

Eleven days of moderate exercise and heat exposure induces acclimation without significant HSP70 and apoptosis responses of lymphocytes in college-aged males

(2011) Lindsay L. Hom et al.   CELL STRESS & CHAPERONES

Aggregation State and Neurotoxic Properties of Alzheimer β-Amyloid Peptide

(2011) Amany Mohamed et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Exercise training attenuates the hypermuscular phenotype and restores skeletal muscle function in the myostatin null mouse

(2011) Antonios Matsakas et al.   EXPERIMENTAL PHYSIOLOGY

The role of ubiquitin–proteasome system in ageing

(2011) Peter Löw   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Heat Shock Proteins and Autophagy in Rats with Cerulein-Induced Acute Pancreatitis

(2011) Jin Nam Kim et al.   Gut and Liver

Proteasome inhibition by quercetin triggers macroautophagy and blocks mTOR activity

(2011) Anja K. Klappan et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Exercise protects against doxorubicin-induced oxidative stress and proteolysis in skeletal muscle

(2011) Ashley J. Smuder et al.   JOURNAL OF APPLIED PHYSIOLOGY

AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1

(2011) Anthony MJ Sanchez et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pre-exercise alkalosis attenuates the heat shock protein 72 response to a single-bout of anaerobic exercise

(2011) Daniel J. Peart et al.   JOURNAL OF SCIENCE AND MEDICINE IN SPORT

AMPK -> ULK1 -> Autophagy

(2011) P. J. Roach   MOLECULAR AND CELLULAR BIOLOGY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

(2011) L. Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Misfolded protein aggregates: Mechanisms, structures and potential for disease transmission

(2011) Ines Moreno-Gonzalez et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis

(2011) Christopher S Fry et al.   Skeletal Muscle

Muscle protein breakdown has a minor role in the protein anabolic response to essential amino acid and carbohydrate intake following resistance exercise

(2010) Erin L. Glynn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

(2010) Liang Qin et al.   Autophagy

Chaperone-assisted degradation: multiple paths to destruction

(2010) Nadja Kettern et al.   BIOLOGICAL CHEMISTRY

LPS-induced cytokine levels are repressed by elevated expression of HSP70 in rats: possible role of NF-κB

(2010) Karol Dokladny et al.   CELL STRESS & CHAPERONES

Heat and exercise acclimation increases intracellular levels of Hsp72 and inhibits exercise-induced increase in intracellular and plasma Hsp72 in humans

(2010) Flávio de Castro Magalhães et al.   CELL STRESS & CHAPERONES

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Living at high altitude in combination with sea-level sprint training increases hematological parameters but does not improve performance in rats

(2010) Vladimir Essau Martinez-Bello et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Effects of whole-body heat acclimation on cell injury and cytokine responses in peripheral blood mononuclear cells

(2010) Fabiano Amorim et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Inhibition of Hsp70 by Methylene Blue Affects Signaling Protein Function and Ubiquitination and Modulates Polyglutamine Protein Degradation

(2010) Adrienne M. Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bolus Arginine Supplementation Affects neither Muscle Blood Flow nor Muscle Protein Synthesis in Young Men at Rest or After Resistance Exercise

(2010) Jason E. Tang et al.   JOURNAL OF NUTRITION

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Autophagy is defective in collagen VI muscular dystrophies and its reactivation rescues myofiber degeneration

(2010) Paolo Grumati et al.   NATURE MEDICINE

Cellular strategies for controlling protein aggregation

(2010) Jens Tyedmers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Association of AMPK with ULK1 Regulates Autophagy

(2010) Jong Woo Lee et al.   PLoS One

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Autophagy gets in on the regulatory act

(2010) S. K. Backues et al.   Journal of Molecular Cell Biology

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

Control of autophagy initiation by phosphoinositide 3-phosphatase jumpy

(2009) Isabelle Vergne et al.   EMBO JOURNAL

Subcellular movement and expression of HSP27, αB-crystallin, and HSP70 after two bouts of eccentric exercise in humans

(2009) G. Paulsen et al.   JOURNAL OF APPLIED PHYSIOLOGY

CCL2 and Interleukin-6 Promote Survival of Human CD11b+Peripheral Blood Mononuclear Cells and Induce M2-type Macrophage Polarization

(2009) Hernan Roca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute exercise modulates the Foxo1/PGC-1α pathway in the liver of diet-induced obesity rats

(2009) Eduardo R. Ropelle et al.   JOURNAL OF PHYSIOLOGY-LONDON

Induction of macroautophagy by heat

(2009) Yuanbo Zhao et al.   MOLECULAR BIOLOGY REPORTS

Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells

(2009) K Zhu et al.   ONCOGENE

Cellular and Molecular Mechanisms of Heat Stress-Induced Up-Regulation of Occludin Protein Expression

(2008) Karol Dokladny et al.   AMERICAN JOURNAL OF PATHOLOGY

Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity

(2008) Gabriella Dobrowolny et al.   Cell Metabolism

Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease

(2008) N. Raben et al.   HUMAN MOLECULAR GENETICS

Heat Acclimation and HSP-72 Expression in Exercising Humans

(2008) A. Watkins et al.   INTERNATIONAL JOURNAL OF SPORTS MEDICINE

Interleukin-6 Markedly Decreases Skeletal Muscle Protein Turnover and Increases Nonmuscle Amino Acid Utilization in Healthy Individuals

(2008) Gerrit van Hall et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Aging Results in Increased Autophagy of Mitochondria and Protein Nitration in Rat Hepatocytes Following Heat Stress

(2008) Terry D. Oberley et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle

(2008) Sarah B. Wilkinson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Constitutive Activation of Chaperone-mediated Autophagy in Cells with Impaired Macroautophagy

(2008) Susmita Kaushik et al.   MOLECULAR BIOLOGY OF THE CELL

OSU-03012 Stimulates PKR-Like Endoplasmic Reticulum-Dependent Increases in 70-kDa Heat Shock Protein Expression, Attenuating Its Lethal Actions in Transformed Cells

(2008) M. A. Park et al.   MOLECULAR PHARMACOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Riluzole Increases the Amount of Latent HSF1 for an Amplified Heat Shock Response and Cytoprotection

(2008) Jingxian Yang et al.   PLoS One

Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle

(2007) Hans C. Dreyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Exercise-heat acclimation in humans alters baseline levels and ex vivo heat inducibility of HSP72 and HSP90 in peripheral blood mononuclear cells

(2007) James P. McClung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Resistance training alters the response of fed state mixed muscle protein synthesis in young men

(2007) Jason E. Tang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY