Article
Biochemistry & Molecular Biology
Andre Luis Araujo Minari, Felipe Avila, Lila Missae Oyama, Ronaldo Vagner Thomatieli dos Santos
Summary: This study aimed to evaluate the relationship between exercise inflammation and the peripheral neuroendocrine system, finding that increased nAChR receptors may contribute to skeletal muscle adaption after exercise.
Article
Sport Sciences
Samantha E. E. Moser, Austin M. M. Brown, Muni Swamy Ganjayi, Jeffrey S. S. Otis, Cory W. W. Baumann
Summary: This study aimed to determine whether muscle recovery is impaired after repetitive bouts of physical stress in skeletal muscle during excessive short-term and long-term alcohol consumption. The results showed that excessive alcohol intake did not affect the muscle's ability to regain strength after repeated bouts of physical stress in a mouse model, suggesting that alcohol may not be as detrimental to recovery as once predicted.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Hospitality, Leisure, Sport & Tourism
Arash Khassetarash, Gianluca Vernillo, Renata L. Kruger, W. Brent Edwards, Guillaume Y. Millet
Summary: This study investigated the effects of the repeated bout effect (RBE) on neuromuscular performance, running biomechanics, and metabolic cost of running using downhill running as a model. The results demonstrated that RBE can attenuate muscle soreness and reduce serum creatine kinase levels. It also showed a decrease in maximum voluntary contraction force loss and voluntary activation. However, changes in running biomechanics did not significantly affect the energy cost of running.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2022)
Article
Multidisciplinary Sciences
Aysel Yildirim, Muaz Belviranli, Nilsel Okudan
Summary: Low-intensity eccentric exercise training performed before high-intensity eccentric exercise can reduce muscle damage by decreasing oxidative stress and increasing antioxidant defense.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)
Article
Geriatrics & Gerontology
Annesofie Thorup Olesen, Lasse Alchow-Moller, Rune Duus Bendixen, Michael Kjaer, Rene Bruggebusch Svensson, Jesper Lovind Andersen, S. Peter Magnusson
Summary: The study showed that ten weeks of high intensity training could attenuate age-related loss of muscle mass and function, with greater effects observed in old mice in the HR group. The HR running increased fiber CSA and shifted fiber types in the older mice, suggesting its effectiveness in counteracting sarcopenia.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Multidisciplinary Sciences
Hirai Suito, Kaoru Fujikawa, Masafumi Ohsako
Summary: Osgood-Schlatter disease (OSD) in adolescents is characterized by inflammation, pain, and prominence at the tibial tuberosity. A study on rats showed that eccentric contractions in the quadriceps can lead to symptoms similar to OSD, such as inflammation, pain, and prominence. Further research is needed to better understand the pathophysiology of OSD and develop effective treatment options.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, Research & Experimental
Colin Harper, Venkatesh Gopalan, Jorming Goh
Summary: This review examines the cellular and molecular changes in skeletal muscle mitochondria during aging, particularly focusing on the efficiency of mitochondrial coupling and its impact on muscle function decline. It also discusses how different exercise modalities can potentially reverse these changes and delay the onset of sarcopenia. Additional concepts such as mitophagy and the implications of muscle fiber type changes with sarcopenia on mitochondrial function are also integrated in this review.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Sport Sciences
Jordan Philpott, Mark Kern, Shirin Hooshmand, Imogene Carson, Vernon Rayo, Elise North, Lauren Okamoto, Timothy O'Neil, Mee Young Hong, Changqi Liu, Gillian Dreczkowski, Nidia Rodriguez-Sanchez, Oliver C. C. Witard, Stuart D. D. Galloway
Summary: The study aimed to examine the effects of pistachio nut consumption on muscle soreness and function after exercise-induced muscle damage. Male team-sport players consumed either control (water), a standard dose of daily pistachios, or a higher dose of daily pistachios. The results showed that the high dose pistachio nut intake reduced quadriceps soreness during exercise recovery, but had no effect on muscle function. Therefore, high dose pistachio nut ingestion may alleviate muscle soreness after muscle damage.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Review
Physiology
Andre Tomalka
Summary: Eccentric muscle loading has unique features including increased force, work, and performance while consuming less oxygen, reduced metabolic cost, and decreased muscle activity. This review summarizes approaches to explain muscular contraction dynamics and molecular and cellular mechanisms underlying eccentric muscle loading. It emphasizes the functional link between sarcomeric components, particularly the essential role of titin in skeletal muscle. The interaction between titin and actin can explain linear force increases in active lengthening experiments. This review aims to contribute to a detailed understanding of muscle behavior, force generation, and disease.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Sport Sciences
Zhen Wang, Yanlong Niu, Bingkai Lei, Liang Yu, Zhifei Ke, Chunxia Cao, Ruiyuan Wang, Junping Li
Summary: Downhill running resulted in a significant increase in protein levels of LC3-II and p62, while the levels and proportion of AcK40 alpha-tubulin were markedly decreased. Additionally, dynein on alpha-tubulin decreased after downhill running, and autophagosomes accumulated in the middle of myofibrils. Importantly, LC3-II flux was decreased after downhill running compared to the control group.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Physiology
Ryo Takagi, Ayaka Tabuchi, Tomoyo Asamura, Seiya Hirayama, Ryo Ikegami, Yoshinori Tanaka, Daisuke Hoshino, David C. Poole, Yutaka Kano
Summary: In a study examining the effects of cooling on intracellular calcium ion concentration after eccentric contractions, it was found that cooling post-exercise could lead to an increase in high [Ca2+](i) sites in muscle cells, potentially exacerbating muscle damage. Additionally, cooling was shown to exacerbate muscle strength deficits and fiber damage induced by eccentric contractions, suggesting a mechanistic basis for how post-exercise cryotherapy may impact muscle function.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Sport Sciences
M. O. S. T. A. F. A. M. ALI, R. Y. A. N. P. MCMILLAN, D. A. N. E. W. FAUSNACHT, J. O. H. N. W. KAVANAUGH, M. O. R. D. E. C. A. I. M. HARVEY, J. O. S. E. P. H. R. STEVENS, Y. A. R. U. WU, R. A. N. D. A. L. L. L. MYNATT, M. A. T. T. H. E. W. W. HULVER
Summary: This study established a novel muscle-specific TLR4 knockout mouse model and identified mTLR4 as an immunomodulatory effector of exercise-induced metabolic adaptations in skeletal muscle.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Medicine, Research & Experimental
Milad Azad, Neda Khaledi, Mehdi Hedayati, Mohammadreza Karbalaie
Summary: The study revealed that the apoptotic response to exercise depends on the type and intensity of exercise, as well as the sensitivity and susceptibility of the muscle. Acute and chronic exercise can significantly affect apoptotic responses in different types of muscles.
Article
Physiology
Patricio A. Pincheira, Ben W. Hoffman, Andrew G. Cresswell, Timothy J. Carroll, Nicholas A. T. Brown, Glen A. Lichtwark
Summary: The study found that stretching an active muscle seems to play a more important role in causing damage than sustained contraction at a long length.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Cell Biology
Alex Brown, Aaron C. Q. Thomas, Aidan A. Hatt, Chris McGlory, Stuart M. Phillips, Dinesh Kumbhare, Gianni Parise, Sophie Joanisse
Summary: This study investigated the acute effects of aerobic conditioning on satellite cells (SCs) and ribosomes in skeletal muscle. The results showed that aerobic conditioning increased the abundance of type-I SCs and the acute increase in ribosome content following eccentric contractions.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Evan J. H. Lewis, Leif E. Lovblom, Maryam Ferdousi, Elise M. Halpern, Maria Jeziorska, Daniele Pacaud, Nicola Pritchard, Cirous Dehghani, Katie Edwards, Sangeetha Srinivasan, Roni Mintz Shtein, Nathan Efron, Mitra Tavakoli, Vera Bril, Rayaz Ahmed Malik, Bruce A. Perkins
Article
Sport Sciences
Michele R. Schaeffer, Emily Mcbride, Reid A. Mitchell, Kyle G. Boyle, Andrew H. Ramsook, Joseph H. Puyat, Meaghan J. Macnutt, Jordan A. Guenette
Summary: This study found that the Turbine (TM) does not reduce the work of breathing and has no effect on dyspnea or exercise capacity during moderate to high exercise intensities.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Nutrition & Dietetics
Andrew H. Ramsook, Yannick Molgat-Seon, Kyle G. Boyle, Reid A. Mitchell, Joseph H. Puyat, Michael S. Koehle, A. William Sheel, Jordan A. Guenette
Summary: The study demonstrates that assessing diaphragm voluntary activation using CMS is reliable in young healthy adults, providing additional insights into the consequences and mechanisms of diaphragm fatigue.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Environmental Sciences
Sarah Koch, Joseph F. Welch, Raymond Tran, Andrew H. Ramsook, Andy Hung, Christopher Carlsten, Jordan A. Guenette, Michael S. Koehle
Summary: The study found that using salbutamol before moderate-intensity exercise in high levels of diesel exhaust did not reduce respiratory function or exercise ventilatory responses, with no significant changes observed up to 60 minutes following exercise.
ENVIRONMENT INTERNATIONAL
(2021)
Letter
Physiology
Andrew H. Ramsook, Carli M. Peters, Michael G. Leahy, Bruno Archiza, Reid A. Mitchell, Tin Jasinovic, Michael S. Koehle, Jordan A. Guenette, Andrew William Sheel
EXPERIMENTAL PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Bruce A. Perkins, Leif Erik Lovblom, Evan J. H. Lewis, Vera Bril, Maryam Ferdousi, Andrej Orszag, Katie Edwards, Nicola Pritchard, Anthony Russell, Cirous Dehghani, Daniele Pacaud, Kenneth Romanchuk, Jean K. Mah, Maria Jeziorska, Andrew Marshall, Roni M. Shtein, Rodica Pop-Busui, Stephen Lentz, Mitra Tavakoli, Andrew J. M. Boulton, Nathan Efron, Rayaz A. Malik
Summary: In this study, corneal nerve fiber length (CNFL) was found to be an effective indicator for predicting the development of diabetic peripheral neuropathy (DPN). It showed good predictive validity for identifying patients at higher risk of developing DPN similar to 6 years in the future.
Article
Sport Sciences
Kyle G. Boyle, Gabby Napoleone, Andrew H. Ramsook, Reid A. Mitchell, Jordan A. Guenette
Summary: This study aims to examine the effects of the Elevation Training Mask (R) 2.0 on dyspnea, respiratory muscle function, and fatigue during exercise. The results indicate that exercising with the ETM can decrease exercise performance and increase the sensation of dyspnea. However, the ETM does not induce respiratory muscle fatigue.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2022)
Article
Critical Care Medicine
Nafeez Syed, Min Hyung Ryu, Satvir Dhillon, Michele R. Schaeffer, Andrew H. Ramsook, Janice M. Leung, Christopher J. Ryerson, Christopher Carlsten, Jordan A. Guenette
Summary: Contrary to our hypothesis, it was the healthy control participants, rather than the former smokers with and without COPD, who were negatively impacted by TRAP during exercise.
Article
Physiology
Reid A. Mitchell, Scott T. Apperley, Satvir S. Dhillon, Julia Zhang, Kyle G. Boyle, Andrew H. Ramsook, Michele R. Schaeffer, Kathryn M. Milne, Yannick Molgat-Seon, A. William Sheel, Jordan A. Guenette
Summary: This case report describes a 59-year-old female 4 years post-left-sided extrapleural pneumonectomy who underwent incremental cycling testing and inspiratory muscle training (IMT) for 12 weeks. Results showed that IMT effectively increased respiratory muscle strength.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Sport Sciences
Andrew H. Ramsook, Michele R. Schaeffer, Reid A. Mitchell, Satvir S. Dhillon, Kathryn M. Milne, Olivia N. Ferguson, Joseph H. Puyat, Michael S. Koehle, A. William Sheel, Jordan A. Guenette
Summary: The study found that both females and males experience a decrease in diaphragm voluntary activation (D-VA) and transdiaphragmatic twitch pressure (P-di,P-TW) after whole-body exercise, but the decrease is significantly less in females compared to males.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Physiology
Andrew H. H. Ramsook, Michele R. R. Schaeffer, Reid A. A. Mitchell, Satvir S. S. Dhillon, Kathryn M. M. Milne, Olivia N. N. Ferguson, Joseph H. H. Puyat, Michael S. S. Koehle, A. William Sheel, Jordan A. A. Guenette
Summary: The impact of neural mechanisms on diaphragm fatigability following inspiratory pressure threshold loading (IPTL) was investigated in males and females. The study found that while there were differences in diaphragm fatigability between males and females after training, there was no significant difference in diaphragm fatigability between the sexes. The results suggest that neural mechanisms contribute to diaphragm fatigability and this contribution is similar between males and females following IPTL.
PHYSIOLOGICAL REPORTS
(2023)
Meeting Abstract
Sport Sciences
Andrew H. Ramsook, Michele R. Schaeffer, Reid A. Mitchell, Satvir S. Dhillon, Kathryn M. Milne, Olivia N. Ferguson, Joseph H. Puyat, Michael S. Koehle, A. William Sheel, Jordan A. Guenette
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Meeting Abstract
Critical Care Medicine
N. Syed, M. H. H. Ryu, S. S. Dhillon, M. R. Schaeffer, C. J. Ryerson, A. H. Ramsook, J. Leung, C. Carlsten, J. A. Guenette
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Meeting Abstract
Critical Care Medicine
R. A. Mitchell, S. Apperley, S. S. Dhillon, J. Zhang, K. G. Boyle, A. H. Ramsook, M. R. Schaeffer, K. M. Milne, J. A. Guenette
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Meeting Abstract
Critical Care Medicine
R. A. Mitchell, S. Apperley, S. S. Dhillon, J. Zhang, K. G. Boyle, A. H. Ramsook, M. R. Schaeffer, K. M. Milne, Y. Molgat-Seon, A. W. Sheel, J. A. Guenette
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)