The very many faces of presenilins and the γ-secretase complex

Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: Implications for lysosomal function

(2012) Kara M Neely Kayala et al.   BRAIN RESEARCH

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

(2012) Estela Area-Gomez et al.   EMBO JOURNAL

Lack of Evidence for Presenilins as Endoplasmic Reticulum Ca2+Leak Channels

(2012) Dustin Shilling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells

(2012) Katrijn Coen et al.   JOURNAL OF CELL BIOLOGY

Pen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both γ-secretase assembly and substrate recruitment

(2012) Guozhang Mao et al.   JOURNAL OF NEUROCHEMISTRY

A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2

(2012) X. Zhang et al.   JOURNAL OF NEUROSCIENCE

Structure of a presenilin family intramembrane aspartate protease

(2012) Xiaochun Li et al.   NATURE

Cellular mechanisms of γ-secretase substrate selection, processing and toxicity

(2012) Gael Barthet et al.   PROGRESS IN NEUROBIOLOGY

Dissociation between the Processivity and Total Activity of γ-Secretase: Implications for the Mechanism of Alzheimer's Disease-Causing Presenilin Mutations

(2011) Omar Quintero-Monzon et al.   BIOCHEMISTRY

Notch signalling in cancer progression and bone metastasis

(2011) N Sethi et al.   BRITISH JOURNAL OF CANCER

Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis

(2011) Charlene Supnet et al.   CELL CALCIUM

γ-Secretase-Regulated Mechanisms Similar to Notch Signaling May Play a Role in Signaling Events, Including APP Signaling, Which Leads to Alzheimer’s Disease

(2011) Kohzo Nakayama et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Nuclear signalling by membrane protein intracellular domains: The AICD enigma

(2011) Caroline Beckett et al.   CELLULAR SIGNALLING

Proteolytic Cleavage of Notch: “HIT and RUN”

(2011) G. van Tetering et al.   CURRENT MOLECULAR MEDICINE

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

Modulation of transient receptor potential melastatin related 7 channel by presenilins

(2011) Hyun Geun Oh et al.   Developmental Neurobiology

Target of γ-secretase modulators, presenilin marks the spot

(2011) Christina J Crump et al.   EMBO JOURNAL

Regulation of developmental intercellular signalling by intracellular trafficking

(2011) Ben-Zion Shilo et al.   EMBO JOURNAL

Structure of γ-Secretase and Its Trimeric Pre-activation Intermediate by Single-particle Electron Microscopy

(2011) Fabiana Renzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polar Transmembrane-based Amino Acids in Presenilin 1 Are Involved in Endoplasmic Reticulum Localization, Pen2 Protein Binding, and γ-Secretase Complex Stabilization

(2011) Matthias Fassler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional and Topological Analysis of Pen-2, the Fourth Subunit of the γ-Secretase Complex

(2011) Leen Bammens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparison of Presenilin 1 and Presenilin 2 γ-Secretase Activities Using a Yeast Reconstitution System

(2011) Yoji Yonemura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutagenesis Mapping of the Presenilin 1 Calcium Leak Conductance Pore

(2011) Omar Nelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of nectin processing mediated by presenilin-dependent gamma-secretase

(2011) Jinsook Kim et al.   JOURNAL OF NEUROCHEMISTRY

Assembly of the presenilin γ-/ε-secretase complex

(2011) P. St George-Hyslop et al.   JOURNAL OF NEUROCHEMISTRY

γ-Secretase inhibitors and modulators for Alzheimer’s disease

(2011) Michael S. Wolfe   JOURNAL OF NEUROCHEMISTRY

Regulated intramembrane proteolysis - lessons from amyloid precursor protein processing

(2011) Stefan F. Lichtenthaler et al.   JOURNAL OF NEUROCHEMISTRY

Presenilin Is Necessary for Efficient Proteolysis through the Autophagy-Lysosome System in a  -Secretase-Independent Manner

(2011) K. M. Neely et al.   JOURNAL OF NEUROSCIENCE

Synaptic Autoregulation by Metalloproteases and  -Secretase

(2011) S. Restituito et al.   JOURNAL OF NEUROSCIENCE

A Novel Role for  -Secretase: Selective Regulation of Spontaneous Neurotransmitter Release from Hippocampal Neurons

(2011) K. G. Pratt et al.   JOURNAL OF NEUROSCIENCE

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Regulated Intramembrane Proteolysis: Signaling Pathways and Biological Functions

(2011) Mark Lal et al.   PHYSIOLOGY

Presenilin/γ-Secretase Regulates Neurexin Processing at Synapses

(2011) Carlos A. Saura et al.   PLoS One

Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+signaling

(2011) Marioly Müller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk

(2011) E. Zampese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intramembrane Proteolysis in Regulated Protein Trafficking

(2011) Marius K. Lemberg   TRAFFIC

Presenilins in synaptic function and disease

(2011) Angela Ho et al.   TRENDS IN MOLECULAR MEDICINE

γ-Secretase component presenilin is important for microglia β-amyloid clearance

(2010) Dorit Farfara et al.   ANNALS OF NEUROLOGY

Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease

(2010) Bart De Strooper et al.   Annual Review of Cell and Developmental Biology

Enhanced ROS Generation Mediated by Alzheimer's Disease Presenilin Regulation of InsP3R Ca2+ Signaling

(2010) Marioly Müller et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy impairment stimulates PS1 expression and γ-secretase activity

(2010) Kazunori Ohta et al.   Autophagy

Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts

(2010) Marko Kosicek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain

(2010) Jenny Frånberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of an Atypical γ-Secretase Complex from Hematopoietic Origin

(2010) Lisa Placanica et al.   BIOCHEMISTRY

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Dictyostelium possesses highly diverged presenilin/ -secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/ -secretase complex

(2010) V. C. McMains et al.   Disease Models & Mechanisms

Aph-1 Associates Directly with Full-length and C-terminal Fragments of γ-Secretase Substrates

(2010) Allen C. Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Secretase Composed of PS1/Pen2/Aph1a Can Cleave Notch and Amyloid Precursor Protein in the Absence of Nicastrin

(2010) G. Zhao et al.   JOURNAL OF NEUROSCIENCE

Role of Presenilins in Neuronal Calcium Homeostasis

(2010) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

Participation of Transmembrane Domain 1 of Presenilin 1 in the Catalytic Pore Structure of the  -Secretase

(2010) S. Takagi et al.   JOURNAL OF NEUROSCIENCE

Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease

(2010) Gen He et al.   NATURE

Synaptic and Endosomal Localization of Active γ-Secretase in Rat Brain

(2010) Susanne Frykman et al.   PLoS One

Identification of an Archaeal Presenilin-Like Intramembrane Protease

(2010) Celia Torres-Arancivia et al.   PLoS One

Structural investigation of the C-terminal catalytic fragment of presenilin 1

(2010) S. Sobhanifar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteolytic processing of protocadherin proteins requires endocytosis

(2010) Sean M. Buchanan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation and intrinsic  -secretase activity of presenilin 1

(2010) K. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Gain-of-Function Enhancement of IP3 Receptor Modal Gating by Familial Alzheimer's Disease-Linked Presenilin Mutants in Human Cells and Mouse Neurons

(2010) K.-H. Cheung et al.   Science Signaling

γ-Secretase-Dependent Cleavage Initiates Notch Signaling from the Plasma Membrane

(2010) Erika B. Sorensen et al.   TRAFFIC

The Multiple Facets of Ubiquitination in the Regulation of Notch Signaling Pathway

(2010) Stéphanie Le Bras et al.   TRAFFIC

Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria

(2009) Estela Area-Gomez et al.   AMERICAN JOURNAL OF PATHOLOGY

In vivo reorganization of the actin cytoskeleton in leaves of Nicotiana tabacum L. transformed with plastin-GFP. Correlation with light-activated chloroplast responses

(2009) Anna Anielska-Mazur et al.   BMC PLANT BIOLOGY

Presenilin-dependent regulated intramembrane proteolysis and γ-secretase activity

(2009) J. V. McCarthy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Receptor endocytosis and signaling in plants

(2009) Niloufer G Irani et al.   CURRENT OPINION IN PLANT BIOLOGY

APH1 Polar Transmembrane Residues Regulate the Assembly and Activity of Presenilin Complexes

(2009) Raphaëlle Pardossi-Piquard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glu-333 of Nicastrin Directly Participates in γ-Secretase Activity

(2009) Daniel R. Dries et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicastrin Is Dispensable for γ-Secretase Protease Activity in the Presence of Specific Presenilin Mutations

(2009) Eugene Futai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Notch updated

(2009) An-Chi Tien et al.   JOURNAL OF CELL BIOLOGY

Presenilin/ -Secretase Cleaves CD46 in Response to Neisseria Infection

(2009) N. J. Weyand et al.   JOURNAL OF IMMUNOLOGY

Presenilins are essential for regulating neurotransmitter release

(2009) Chen Zhang et al.   NATURE

Pathways and mechanisms of endocytic recycling

(2009) Barth D. Grant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endocytosis and signalling: intertwining molecular networks

(2009) Alexander Sorkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CD147, a γ-secretase associated protein is upregulated in Alzheimer's disease brain and its cellular trafficking is affected by presenilin-2

(2009) Jarmila Nahalkova et al.   NEUROCHEMISTRY INTERNATIONAL

γ-Secretase in biology and medicine

(2009) Michael S. Wolfe   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Endocytic Regulation of Notch Signalling During Development

(2009) Maximilian Fürthauer et al.   TRAFFIC

Masking of Transmembrane-Based Retention Signals Controls ER Export of γ-Secretase

(2009) Matthias Fassler et al.   TRAFFIC

MAM: more than just a housekeeper

(2009) Teruo Hayashi et al.   TRENDS IN CELL BIOLOGY

Novel Role of Presenilins in Maturation and Transport of Integrin β1†

(2008) Kun Zou et al.   BIOCHEMISTRY

Assembly, Maturation, and Trafficking of the γ-Secretase Complex in Alzheimers Disease

(2008) Daniel Dries et al.   Current Alzheimer Research

Intracellular trafficking of Notch receptors and ligands

(2008) Christel Brou   EXPERIMENTAL CELL RESEARCH

Signaling from endosomes: Location makes a difference

(2008) Lukasz Sadowski et al.   EXPERIMENTAL CELL RESEARCH

Transmembrane Domain 9 of Presenilin Determines the Dynamic Conformation of the Catalytic Site of γ-Secretase

(2008) Alexandra Tolia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Cross-linking Provides a Model of the γ-Secretase Complex Subunit Architecture and Evidence for Close Proximity of the C-terminal Fragment of Presenilin with APH-1

(2008) Harald Steiner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical Coupling Supports the Local Ca2+Transfer between Sarcoplasmic Reticulum Subdomains and the Mitochondria in Heart Muscle

(2008) Cecilia García-Pérez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endosomal entry regulates Notch receptor activation inDrosophila melanogaster

(2008) Thomas Vaccari et al.   JOURNAL OF CELL BIOLOGY

Building γ-secretase – the bits and pieces

(2008) Dragana Spasic et al.   JOURNAL OF CELL SCIENCE

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production

(2008) Kim N. Green et al.   JOURNAL OF GENERAL PHYSIOLOGY

Cryoelectron Microscopy Structure of Purified γ-Secretase at 12 Å Resolution

(2008) Pamela Osenkowski et al.   JOURNAL OF MOLECULAR BIOLOGY

Loss of  -Secretase Function Impairs Endocytosis of Lipoprotein Particles and Membrane Cholesterol Homeostasis

(2008) I. Y. Tamboli et al.   JOURNAL OF NEUROSCIENCE

The C-Terminal PAL Motif and Transmembrane Domain 9 of Presenilin 1 Are Involved in the Formation of the Catalytic Pore of the  -Secretase

(2008) C. Sato et al.   JOURNAL OF NEUROSCIENCE

Dendritic Spine Loss and Synaptic Alterations in Alzheimer’s Disease

(2008) Marlen Knobloch et al.   MOLECULAR NEUROBIOLOGY

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON

Plant Receptors Go Endosomal: A Moving View on Signal Transduction

(2008) N. Geldner et al.   PLANT PHYSIOLOGY

Trafficking, a key player in regulated intramembrane proteolysis

(2008) Ragna Sannerud et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Systems Biology of Growth Factor-Induced Receptor Endocytosis

(2008) Yaara Zwang et al.   TRAFFIC

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES

Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements

(2008) Matthew L Hemming et al.   PLOS BIOLOGY

The cytosolic N-terminus of presenilin-1 potentiates mouse ryanodine receptor single channel activity

(2007) Volodymyr Rybalchenko et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY