γ-Secretase-Regulated Mechanisms Similar to Notch Signaling May Play a Role in Signaling Events, Including APP Signaling, Which Leads to Alzheimer’s Disease

The amyloid precursor protein intracellular domain alters gene expression and induces neuron-specific apoptosis

(2010) Takeshi Ohkawara et al.   GENE

β-Amyloid precursor protein metabolism: focus on the functions and degradation of its intracellular domain

(2010) Erica Buoso et al.   PHARMACOLOGICAL RESEARCH

Transgenic Expression of the Amyloid-β Precursor Protein-Intracellular Domain Does Not Induce Alzheimer's Disease–Like Traits In Vivo

(2010) Luca Giliberto et al.   PLoS One

Presenilin-dependent regulated intramembrane proteolysis and γ-secretase activity

(2009) J. V. McCarthy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

c-Abl modulates AICD dependent cellular responses: Transcriptional induction and apoptosis

(2009) Mary C. Vázquez et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Alzheimer's theory makes a splash

(2009) Jim Schnabel   NATURE

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

(2009) K. Ghosal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroscience: The plaque plan

(2008) Alison Abbott   NATURE

The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis

(2008) Kohzo Nakayama et al.   NEUROSCIENCE LETTERS

Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set

(2008) Winnie S. Liang et al.   PHYSIOLOGICAL GENOMICS

The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics—Relevance for Alzheimer's disease

(2008) Thorsten Müller et al.   PROGRESS IN NEUROBIOLOGY

Similar Mechanisms Regulated by γ-Secretase are Involved in Both Directions of the Bi-Directional Notch-Delta Signaling Pathway as well as Play a Potential Role in Signaling Events Involving Type 1 Transmembrane Proteins

(2008) Kohzo Nakayama et al.   Current Stem Cell Research & Therapy