Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Role of Presenilins in Neuronal Calcium Homeostasis

(2010) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells

(2010) C. D. Dunn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Purification, Pharmacological Modulation, and Biochemical Characterization of Interactors of Endogenous Human γ-Secretase†

(2009) Edith Winkler et al.   BIOCHEMISTRY

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Presenilin-dependent regulated intramembrane proteolysis and γ-secretase activity

(2009) J. V. McCarthy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The 28-amino acid form of an APLP1-derived Aβ-like peptide is a surrogate marker for Aβ42 production in the central nervous system

(2009) Kanta Yanagida et al.   EMBO Molecular Medicine

Peptide EphB2/CTF2 Generated by the γ-Secretase Processing of EphB2 Receptor Promotes Tyrosine Phosphorylation and Cell Surface Localization ofN-Methyl-d-aspartate Receptors

(2009) Jindong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of  -Carboxyl Terminal Fragment

(2009) M. Takami et al.   JOURNAL OF NEUROSCIENCE

How intramembrane proteases bury hydrolytic reactions in the membrane

(2009) Elinor Erez et al.   NATURE

Analysis of the γ-secretase interactome and validation of its association with tetraspanin-enriched microdomains

(2009) Tomoko Wakabayashi et al.   NATURE CELL BIOLOGY

Nuclear signalling by tumour-associated antigen EpCAM

(2009) Dorothea Maetzel et al.   NATURE CELL BIOLOGY

Gender- and Age-Dependent γ-Secretase Activity in Mouse Brain and Its Implication in Sporadic Alzheimer Disease

(2009) Lisa Placanica et al.   PLoS One

The Orphan G Protein-Coupled Receptor 3 Modulates Amyloid-Beta Peptide Generation in Neurons

(2009) A. Thathiah et al.   SCIENCE

 -Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

(2009) L. Serneels et al.   SCIENCE

Signal peptide peptidases: A family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins

(2009) Todd E. Golde et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Toward Structural Elucidation of the γ-Secretase Complex

(2009) Huilin Li et al.   STRUCTURE

Rhomboid Proteases and their Biological Functions

(2008) Matthew Freeman   Annual Review of Genetics

Novel Role of Presenilins in Maturation and Transport of Integrin β1†

(2008) Kun Zou et al.   BIOCHEMISTRY

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

(2008) W. R. Gordon et al.   BLOOD

The N-terminus of presenilin-2 increases single channel activity of brain ryanodine receptors through direct protein–protein interaction

(2008) Volodya Hayrapetyan et al.   CELL CALCIUM

p120 Catenin Recruits Cadherins to γ-Secretase and Inhibits Production of Aβ Peptide

(2008) Zen Kouchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glu332in the Nicastrin Ectodomain Is Essential for γ-Secretase Complex Maturation but Not for Its Activity

(2008) Lucía Chávez-Gutiérrez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-Palmitoylation of γ-Secretase Subunits Nicastrin and APH-1

(2008) Haipeng Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmembrane Domain 9 of Presenilin Determines the Dynamic Conformation of the Catalytic Site of γ-Secretase

(2008) Alexandra Tolia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Cross-linking Provides a Model of the γ-Secretase Complex Subunit Architecture and Evidence for Close Proximity of the C-terminal Fragment of Presenilin with APH-1

(2008) Harald Steiner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment

(2008) Pamela Osenkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutive Internalization of G Protein-coupled Receptors and G Proteins via Clathrin-independent Endocytosis

(2008) Marco Scarselli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production

(2008) Kim N. Green et al.   JOURNAL OF CELL BIOLOGY

Cryoelectron Microscopy Structure of Purified γ-Secretase at 12 Å Resolution

(2008) Pamela Osenkowski et al.   JOURNAL OF MOLECULAR BIOLOGY

The C-Terminal PAL Motif and Transmembrane Domain 9 of Presenilin 1 Are Involved in the Formation of the Catalytic Pore of the  -Secretase

(2008) C. Sato et al.   JOURNAL OF NEUROSCIENCE

Substrate-targeting γ-secretase modulators

(2008) Thomas L. Kukar et al.   NATURE

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON

The many facets of Notch ligands

(2008) B D'Souza et al.   ONCOGENE

Presenilins: Members of the γ-Secretase Quartets, But Part-Time Soloists Too

(2008) Tomoko Wakabayashi et al.   PHYSIOLOGY

Deficiency of Aph1B/C- -secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment

(2008) T. Dejaegere et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and function of γ-secretase

(2008) Alexandra Tolia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Trafficking, a key player in regulated intramembrane proteolysis

(2008) Ragna Sannerud et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES

Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements

(2008) Matthew L Hemming et al.   PLOS BIOLOGY