Promiscuity as a functional trait: intrinsically disordered regions as central players of interactomes

A Folded Excited State of Ligand-Free Nuclear Coactivator Binding Domain (NCBD) Underlies Plasticity in Ligand Recognition

(2013) Magnus Kjaergaard et al.   BIOCHEMISTRY

System-wide Analysis Reveals Intrinsically Disordered Proteins Are Prone to Ubiquitylation after Misfolding Stress

(2013) Alex H. M. Ng et al.   MOLECULAR & CELLULAR PROTEOMICS

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

(2013) Hong Joo Kim et al.   NATURE

Functional Diversity and Structural Disorder in the Human Ubiquitination Pathway

(2013) Pallab Bhowmick et al.   PLoS One

The switches.ELM Resource: A Compendium of Conditional Regulatory Interaction Interfaces

(2013) K. Van Roey et al.   Science Signaling

Structure and Intrinsic Disorder in Protein Autoinhibition

(2013) Travis Trudeau et al.   STRUCTURE

Describing sequence–ensemble relationships for intrinsically disordered proteins

(2012) Albert H. Mao et al.   BIOCHEMICAL JOURNAL

Diverse functional manifestations of intrinsic structural disorder in molecular chaperones

(2012) Denes Kovacs et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

How is functional specificity achieved through disordered regions of proteins?

(2012) Rahul K. Das et al.   BIOESSAYS

The identification of short linear motif-mediated interfaces within the human interactome

(2012) R. J. Weatheritt et al.   BIOINFORMATICS

MoRFpred, a computational tool for sequence-based prediction and characterization of short disorder-to-order transitioning binding regions in proteins

(2012) Fatemeh Miri Disfani et al.   BIOINFORMATICS

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

Getting RNA and Protein in Phase

(2012) Stephanie C. Weber et al.   CELL

Cell-free Formation of RNA Granules: Bound RNAs Identify Features and Components of Cellular Assemblies

(2012) Tina W. Han et al.   CELL

Motif switches: decision-making in cell regulation

(2012) Kim Van Roey et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

An intrinsically disordered yeast prion arrests the cell cycle by sequestering a spindle pole body component

(2012) Sebastian Treusch et al.   JOURNAL OF CELL BIOLOGY

Physical Chemistry of Polyglutamine: Intriguing Tales of a Monotonous Sequence

(2012) Ronald Wetzel   JOURNAL OF MOLECULAR BIOLOGY

The Role of Structural Disorder in the Rewiring of Protein Interactions through Evolution

(2012) Roberto Mosca et al.   MOLECULAR & CELLULAR PROTEOMICS

Rewiring the dynamic interactome

(2012) Melissa J. Davis et al.   Molecular BioSystems

Tissue-Specific Alternative Splicing Remodels Protein-Protein Interaction Networks

(2012) Jonathan D. Ellis et al.   MOLECULAR CELL

Tissue-Specific Splicing of Disordered Segments that Embed Binding Motifs Rewires Protein Interaction Networks

(2012) Marija Buljan et al.   MOLECULAR CELL

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Linear motifs confer functional diversity onto splice variants

(2012) Robert J. Weatheritt et al.   NUCLEIC ACIDS RESEARCH

D2P2: database of disordered protein predictions

(2012) Matt E. Oates et al.   NUCLEIC ACIDS RESEARCH

Versatility from Protein Disorder

(2012) M. M. Babu et al.   SCIENCE

Recognition Pliability Is Coupled to Structural Heterogeneity: A Calmodulin Intrinsically Disordered Binding Region Complex

(2012) Malini Nagulapalli et al.   STRUCTURE

Conditional disorder in chaperone action

(2012) James C.A. Bardwell et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cellular Strategies for Regulating Functional and Nonfunctional Protein Aggregation

(2012) Jörg Gsponer et al.   Cell Reports

Inhibitory Effects of Robo2 on Nephrin: A Crosstalk between Positive and Negative Signals Regulating Podocyte Structure

(2012) Xueping Fan et al.   Cell Reports

Assessing the utility of gene co-expression stability in combination with correlation in the analysis of protein-protein interaction networks

(2011) Ashwini Patil et al.   BMC GENOMICS

A Protein Complex Network of Drosophila melanogaster

(2011) K.G. Guruharsha et al.   CELL

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

Intrinsically disordered proteins: regulation and disease

(2011) M Madan Babu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Sequence correlations shape protein promiscuity

(2011) David B. Lukatsky et al.   JOURNAL OF CHEMICAL PHYSICS

Multi-Scale Sequence Correlations Increase Proteome Structural Disorder and Promiscuity

(2011) Ariel Afek et al.   JOURNAL OF MOLECULAR BIOLOGY

N-Terminal Segments Modulate the α-Helical Propensities of the Intrinsically Disordered Basic Regions of bZIP Proteins

(2011) Rahul K. Das et al.   JOURNAL OF MOLECULAR BIOLOGY

Direct Observations of Conformational Distributions of Intrinsically Disordered p53 Peptides Using UV Raman and Explicit Solvent Simulations

(2011) Kan Xiong et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Location of disorder in coiled coilproteins is influenced by its biological role and subcellular localization: a GO-based study on human proteome

(2011) Meenakshi Anurag et al.   Molecular BioSystems

Intrinsically disordered proteins as molecular shields

(2011) Sohini Chakrabortee et al.   Molecular BioSystems

Attributes of short linear motifs

(2011) Norman E. Davey et al.   Molecular BioSystems

Fuzziness: linking regulation to protein dynamics

(2011) Monika Fuxreiter   Molecular BioSystems

Disorder Targets Misorder in Nuclear Quality Control Degradation: A Disordered Ubiquitin Ligase Directly Recognizes Its Misfolded Substrates

(2011) Joel C. Rosenbaum et al.   MOLECULAR CELL

Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21

(2011) Yuefeng Wang et al.   Nature Chemical Biology

ELM--the database of eukaryotic linear motifs

(2011) H. Dinkel et al.   NUCLEIC ACIDS RESEARCH

Experimental and computational approaches for the study of calmodulin interactions

(2011) A.S.N. Reddy et al.   PHYTOCHEMISTRY

Intrinsic disorder: signaling via highly specific but short-lived association

(2011) Huan-Xiang Zhou   TRENDS IN BIOCHEMICAL SCIENCES

Low-complexity regions within protein sequences have position-dependent roles

(2010) Alain Coletta et al.   BMC Systems Biology

Protein binding specificity versus promiscuity

(2010) Gideon Schreiber et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Hub Promiscuity in Protein-Protein Interaction Networks

(2010) Ashwini Patil et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intrinsic disorder and protein multibinding in domain, terminal, and linker regions

(2010) Jessica H. Fong et al.   Molecular BioSystems

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

Net charge per residue modulates conformational ensembles of intrinsically disordered proteins

(2010) A. H. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational selection in the molten globule state of the nuclear coactivator binding domain of CBP

(2010) Magnus Kjaergaard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Domain distribution and intrinsic disorder in hubs in the human protein-protein interaction network

(2010) Ashwini Patil et al.   PROTEIN SCIENCE

The molecular regulation of programmed necrotic cell injury

(2010) David Moquin et al.   TRENDS IN BIOCHEMICAL SCIENCES

Intrinsic Protein Disorder and Interaction Promiscuity Are Widely Associated with Dosage Sensitivity

(2009) Tanya Vavouri et al.   CELL

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Limitations of Induced Folding in Molecular Recognition by Intrinsically Disordered Proteins

(2009) Eszter Hazy et al.   CHEMPHYSCHEM

Linking folding and binding

(2009) Peter E Wright et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Interaction between Intrinsically Disordered Proteins Frequently Occurs in a Human Protein–Protein Interaction Network

(2009) Kana Shimizu et al.   JOURNAL OF MOLECULAR BIOLOGY

RNA granules: post-transcriptional and epigenetic modulators of gene expression

(2009) Paul Anderson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evidence for the Concerted Evolution between Short Linear Protein Motifs and Their Flanking Regions

(2009) Claudia Chica et al.   PLoS One

Structural plasticity of an acid-activated chaperone allows promiscuous substrate binding

(2009) T. L. Tapley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Signaling in Space and Time: Where Proteins Come Together and When They're Apart

(2009) J. D. Scott et al.   SCIENCE

Cell regulation: determined to signal discrete cooperation

(2009) Toby J. Gibson   TRENDS IN BIOCHEMICAL SCIENCES

Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data

(2009) Yvonne JK Edwards et al.   GENOME BIOLOGY

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

The unfoldomics decade: an update on intrinsically disordered proteins

(2008) A Keith Dunker et al.   BMC GENOMICS

Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners

(2008) Christopher J Oldfield et al.   BMC GENOMICS

Bleach Activates a Redox-Regulated Chaperone by Oxidative Protein Unfolding

(2008) J. Winter et al.   CELL

A role for Q/N-rich aggregation-prone regions in P-body localization

(2008) M. A. M. Reijns et al.   JOURNAL OF CELL SCIENCE

Contextual Specificity in Peptide-Mediated Protein Interactions

(2008) Amelie Stein et al.   PLoS One

Tight Regulation of Unstructured Proteins: From Transcript Synthesis to Protein Degradation

(2008) J. Gsponer et al.   SCIENCE

Identification of transient hub proteins and the possible structural basis for their multiple interactions

(2007) Miho Higurashi et al.   PROTEIN SCIENCE

Fuzzy complexes: polymorphism and structural disorder in protein–protein interactions

(2007) Peter Tompa et al.   TRENDS IN BIOCHEMICAL SCIENCES