A decade and a half of protein intrinsic disorder: Biology still waits for physics

Intrinsically disordered regions of p53 family are highly diversified in evolution

(2013) Bin Xue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Inherent Relationships among Different Biophysical Prediction Methods for Intrinsically Disordered Proteins

(2013) Fan Jin et al.   BIOPHYSICAL JOURNAL

Flexibility and Reactivity in Promiscuous Enzymes

(2013) Pietro Gatti-Lafranconi et al.   CHEMBIOCHEM

HSF Transcription Factor Family, Heat Shock Response, and Protein Intrinsic Disorder

(2012) Sandy D. Westerheide et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Intrinsically disordered proteins and novel strategies for drug discovery

(2012) Vladimir N. Uversky   Expert Opinion on Drug Discovery

The Roles of Intrinsic Disorder in Orchestrating the Wnt-Pathway

(2012) Bin Xue et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Orderly order in protein intrinsic disorder distribution: disorder in 3500 proteomes from viruses and the three domains of life

(2012) Bin Xue et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Chemical composition is maintained in poorly conserved intrinsically disordered regions and suggests a means for their classification

(2012) Harry Amri Moesa et al.   Molecular BioSystems

More than just tails: intrinsic disorder in histone proteins

(2012) Zhenling Peng et al.   Molecular BioSystems

Sequence Evolution of the Intrinsically Disordered and Globular Domains of a Model Viral Oncoprotein

(2012) Lucía B. Chemes et al.   PLoS One

Exploring the binding diversity of intrinsically disordered proteins involved in one-to-many binding

(2012) Wei-Lun Hsu et al.   PROTEIN SCIENCE

α-Synuclein misfolding and Parkinson's disease

(2011) Leonid Breydo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Intrinsically disordered proteins may escape unwanted interactions via functional misfolding

(2011) Vladimir N. Uversky   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Evolution and disorder

(2011) Celeste J Brown et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Intrinsically disordered proteins from A to Z

(2011) Vladimir N. Uversky   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Short-Lived Signaling State of the Photoactive Yellow Protein Photoreceptor Revealed by Combined Structural Probes

(2011) Pradeep L. Ramachandran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Relationships Among MicroRNA Regulation, Intrinsically Disordered Regions, and Other Indicators of Protein Evolutionary Rate

(2011) S. C.-C. Chen et al.   MOLECULAR BIOLOGY AND EVOLUTION

Insights in the (un)structural organization of Bacillus pasteurii UreG, an intrinsically disordered GTPase enzyme

(2011) Barbara Zambelli et al.   Molecular BioSystems

Protein intrinsic disorder and induced pluripotent stem cells

(2011) Bin Xue et al.   Molecular BioSystems

Structural adaptation of extreme halophilic proteins through decrease of conserved hydrophobic contact surface

(2011) Alessandro Siglioccolo et al.   BMC STRUCTURAL BIOLOGY

Proteome-wide evidence for enhanced positive Darwinian selection within intrinsically disordered regions in proteins

(2011) Johan Nilsson et al.   GENOME BIOLOGY

Understanding protein non-folding

(2010) Vladimir N. Uversky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Archaic chaos: intrinsically disordered proteins in Archaea

(2010) Bin Xue et al.   BMC Systems Biology

Multitude of binding modes attainable by intrinsically disordered proteins: a portrait gallery of disorder-based complexes

(2010) Vladimir N. Uversky   CHEMICAL SOCIETY REVIEWS

Oncogenic Partnerships: EWS-FLI1 Protein Interactions Initiate Key Pathways of Ewing's Sarcoma

(2010) H. V. Erkizan et al.   CLINICAL CANCER RESEARCH

Enzymatic activity in disordered states of proteins

(2010) Michele Vendruscolo   CURRENT OPINION IN CHEMICAL BIOLOGY

Protein dynamics: dancing on an ever-changing free energy stage

(2010) Dennis R Livesay   CURRENT OPINION IN PHARMACOLOGY

Drugs for ‘protein clouds’: targeting intrinsically disordered transcription factors

(2010) A Keith Dunker et al.   CURRENT OPINION IN PHARMACOLOGY

An improved open-channel structure of MscL determined from FRET confocal microscopy and simulation

(2010) Ben Corry et al.   JOURNAL OF GENERAL PHYSIOLOGY

A Bimodal Distribution of Two Distinct Categories of Intrinsically Disordered Structures with Separate Functions in FG Nucleoporins

(2010) Justin Yamada et al.   MOLECULAR & CELLULAR PROTEOMICS

A formal test of the theory of universal common ancestry

(2010) Douglas L. Theobald   NATURE

Reduction in Structural Disorder and Functional Complexity in the Thermal Adaptation of Prokaryotes

(2010) Prasad V. Burra et al.   PLoS One

Net charge per residue modulates conformational ensembles of intrinsically disordered proteins

(2010) A. H. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Charge interactions can dominate the dimensions of intrinsically disordered proteins

(2010) S. Muller-Spath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral Disorder or Disordered Viruses: Do Viral Proteins Possess Unique Features?

(2010) Bin Xue et al.   PROTEIN AND PEPTIDE LETTERS

Structure/Function Implications in a Dynamic Complex of the Intrinsically Disordered Sic1 with the Cdc4 Subunit of an SCF Ubiquitin Ligase

(2010) Tanja Mittag et al.   STRUCTURE

Revisiting Date and Party Hubs: Novel Approaches to Role Assignment in Protein Interaction Networks

(2010) Sumeet Agarwal et al.   PLoS Computational Biology

Membrane binding mode of intrinsically disordered cytoplasmic domains of T cell receptor signaling subunits depends on lipid composition

(2009) Alexander B. Sigalov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Close encounters of the third kind: disordered domains and the interactions of proteins

(2009) Peter Tompa et al.   BIOESSAYS

Unfoldomics of human diseases: linking protein intrinsic disorder with diseases

(2009) Vladimir N Uversky et al.   BMC GENOMICS

Predicting intrinsic disorder in proteins: an overview

(2009) Bo He et al.   CELL RESEARCH

Limitations of Induced Folding in Molecular Recognition by Intrinsically Disordered Proteins

(2009) Eszter Hazy et al.   CHEMPHYSCHEM

Linking folding and binding

(2009) Peter E Wright et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

High levels of structural disorder in scaffold proteins as exemplified by a novel neuronal protein, CASK-interactive protein1

(2009) Annamária Balázs et al.   FEBS Journal

Folding by Numbers: Primary Sequence Statistics and Their Use in Studying Protein Folding

(2009) Brent Wathen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Mysterious Unfoldome: Structureless, Underappreciated, Yet Vital Part of Any Given Proteome

(2009) Vladimir N. Uversky   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Multiple Independent Binding Sites for Small-Molecule Inhibitors on the Oncoprotein c-Myc

(2009) Dalia I. Hammoudeh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analysis of structured and intrinsically disordered regions of transmembrane proteins

(2009) Bin Xue et al.   Molecular BioSystems

Intrinsically Disordered Proteins and Their Environment: Effects of Strong Denaturants, Temperature, pH, Counter Ions, Membranes, Binding Partners, Osmolytes, and Macromolecular Crowding

(2009) Vladimir N. Uversky   PROTEIN JOURNAL

Structural Basis for the Aminoacid Composition of Proteins from Halophilic Archea

(2009) Xavier Tadeo et al.   PLOS BIOLOGY

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

The Intrinsically Disordered Cytoplasmic Domain of the T Cell Receptor ζ Chain Binds to the Nef Protein of Simian Immunodeficiency Virus without a Disorder-to-Order Transition†

(2008) Alexander B. Sigalov et al.   BIOCHEMISTRY

Relative Tolerance of an Enzymatic Molten Globule and Its Thermostable Counterpart to Point Mutation†

(2008) Kenneth J. Woycechowsky et al.   BIOCHEMISTRY

Investigation of transmembrane proteins using a computational approach

(2008) Jack Y Yang et al.   BMC GENOMICS

The unfoldomics decade: an update on intrinsically disordered proteins

(2008) A Keith Dunker et al.   BMC GENOMICS

Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners

(2008) Christopher J Oldfield et al.   BMC GENOMICS

Function and structure of inherently disordered proteins

(2008) A Keith Dunker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A careful disorderliness in the proteome: Sites for interaction and targets for future therapies

(2008) Robert B. Russell et al.   FEBS LETTERS

ABSINTH: A new continuum solvation model for simulations of polypeptides in aqueous solutions

(2008) Andreas Vitalis et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Kinetics and Thermodynamics of Ligand Binding to a Molten Globular Enzyme and Its Native Counterpart

(2008) Katherina Vamvaca et al.   JOURNAL OF MOLECULAR BIOLOGY

Atomistic Simulations of the Effects of Polyglutamine Chain Length and Solvent Quality on Conformational Equilibria and Spontaneous Homodimerization

(2008) Andreas Vitalis et al.   JOURNAL OF MOLECULAR BIOLOGY

Prevalence of Intrinsic Disorder in the Intracellular Region of Human Single-Pass Type I Proteins: The Case of the Notch Ligand Delta-4

(2008) Alfredo De Biasio et al.   JOURNAL OF PROTEOME RESEARCH

Protein Disorder Is Positively Correlated with Gene Expression inEscherichia coli

(2008) Oleg Paliy et al.   JOURNAL OF PROTEOME RESEARCH

Large-Scale Analysis of Thermostable, Mammalian Proteins Provides Insights into the Intrinsically Disordered Proteome

(2008) Charles A. Galea et al.   JOURNAL OF PROTEOME RESEARCH

Natively Unfolded Protein Stability as a Coil-to-Globule Transition in Charge/Hydropathy Space

(2008) Henry S. Ashbaugh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of Backbone−Solvent Interactions in Determining Conformational Equilibria of Intrinsically Disordered Proteins

(2008) Hoang T. Tran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

How much of protein sequence space has been explored by life on Earth?

(2008) D. T.F Dryden et al.   Journal of the Royal Society Interface

Intrinsic disorder in pathogenic and non-pathogenic microbes: discovering and analyzing the unfoldomes of early-branching eukaryotes

(2008) Amrita Mohan et al.   Molecular BioSystems

Malleable machines take shape in eukaryotic transcriptional regulation

(2008) Monika Fuxreiter et al.   Nature Chemical Biology

Signal transduction via unstructured protein conduits

(2008) A Keith Dunker et al.   Nature Chemical Biology

Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor

(2008) T. Mittag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prediction of membrane-protein topology from first principles

(2008) A. Bernsel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsic disorder in scaffold proteins: Getting more from less

(2008) Marc S. Cortese et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

TOP-IDP-Scale: A New Amino Acid Scale Measuring Propensity for Intrinsic Disorder

(2008) Andrew Campen et al.   PROTEIN AND PEPTIDE LETTERS

Tight Regulation of Unstructured Proteins: From Transcript Synthesis to Protein Degradation

(2008) J. Gsponer et al.   SCIENCE

Malleable Machines in Transcription Regulation: The Mediator Complex

(2008) Ágnes Tóth-Petróczy et al.   PLoS Computational Biology

Protein structure protection commits gene expression patterns

(2008) Jianping Chen et al.   GENOME BIOLOGY

Molecular signature of hypersaline adaptation: insights from genome and proteome composition of halophilic prokaryotes

(2008) Sandip Paul et al.   GENOME BIOLOGY

Fuzzy complexes: polymorphism and structural disorder in protein–protein interactions

(2007) Peter Tompa et al.   TRENDS IN BIOCHEMICAL SCIENCES

Thoroughly sampling sequence space: Large-scale protein design of structural ensembles

(2002) Stefan M. Larson et al.   PROTEIN SCIENCE