Regulated unfolding of proteins in signaling

PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis

(2013) Ariele Viacava Follis et al.   Nature Chemical Biology

Conformational selection and induced changes along the catalytic cycle ofEscherichia colidihydrofolate reductase

(2013) Thomas R. Weikl et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

A novel type of allosteric regulation: Functional cooperativity in monomeric proteins

(2012) Ilia G. Denisov et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cell cycle regulation by the intrinsically disordered proteins p21 and p27

(2012) Mi-Kyung Yoon et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Disorder-function relationships for the cell cycle regulatory proteins p21 and p27

(2012) Diana M. Mitrea et al.   BIOLOGICAL CHEMISTRY

Order out of Disorder: Working Cycle of an Intrinsically Unfolded Chaperone

(2012) Dana Reichmann et al.   CELL

Direct observation of proteolytic cleavage at the S2 site upon forced unfolding of the Notch negative regulatory region

(2012) N. L. Stephenson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin

(2012) D. Ambort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Designing redox potential-controlled protein switches based on mutually exclusive proteins

(2012) Qing Peng et al.   PROTEIN SCIENCE

Versatility from Protein Disorder

(2012) M. M. Babu et al.   SCIENCE

Conditional disorder in chaperone action

(2012) James C.A. Bardwell et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structural Characterization of Two Alternate Conformations in a Calbindin D9k-Based Molecular Switch

(2011) Margaret M. Stratton et al.   BIOCHEMISTRY

Native-State Interconversion of a Metamorphic Protein Requires Global Unfolding

(2011) Robert C. Tyler et al.   BIOCHEMISTRY

ClpXP, an ATP-powered unfolding and protein-degradation machine

(2011) Tania A. Baker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Protein folding at single-molecule resolution

(2011) Allan Chris M. Ferreon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A Conditional Gating Mechanism Assures the Integrity of the Molecular Force-Sensor Titin Kinase

(2011) Stefan W. Stahl et al.   BIOPHYSICAL JOURNAL

High-Speed AFM Reveals the Dynamics of Single Biomolecules at the Nanometer Scale

(2011) Allard J. Katan et al.   CELL

Lipid-Mediated Folding/Unfolding of Phospholamban as a Regulatory Mechanism for the Sarcoplasmic Reticulum Ca2+-ATPase

(2011) Martin Gustavsson et al.   JOURNAL OF MOLECULAR BIOLOGY

Force-Induced Unfolding Simulations of the Human Notch1 Negative Regulatory Region: Possible Roles of the Heterodimerization Domain in Mechanosensing

(2011) Jianhan Chen et al.   PLoS One

Probing Protein Dynamics by Nuclear Magnetic Resonance

(2011) Kong Hung Sze et al.   PROTEIN AND PEPTIDE LETTERS

Change in Allosteric Network Affects Binding Affinities of PDZ Domains: Analysis through Perturbation Response Scanning

(2011) Z. Nevin Gerek et al.   PLoS Computational Biology

Proteome-wide evidence for enhanced positive Darwinian selection within intrinsically disordered regions in proteins

(2011) Johan Nilsson et al.   GENOME BIOLOGY

Alteration of the α-Synuclein Folding Landscape by a Mutation Related to Parkinson’s Disease

(2010) Allan Chris M. Ferreon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The effect of shear stress on protein conformation

(2010) Enrico Di Stasio et al.   BIOPHYSICAL CHEMISTRY

Unfolding the A2 Domain of Von Willebrand Factor with the Optical Trap

(2010) Junyi Ying et al.   BIOPHYSICAL JOURNAL

Proteins that switch folds

(2010) Philip N Bryan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

KSRP, many functions for a single protein

(2010) Paola Briata   Frontiers in Bioscience-Landmark

Unfolding of Metastable Linker Region Is at the Core of Hsp33 Activation as a Redox-regulated Chaperone

(2010) Claudia M. Cremers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis for the Recognition of Phosphorylated STAT1 by Importin α5

(2010) Jonathan Nardozzi et al.   JOURNAL OF MOLECULAR BIOLOGY

Multicolor single-molecule FRET to explore protein folding and binding

(2010) Yann Gambin et al.   Molecular BioSystems

Protein refolding by pH-triggered chaperone binding and release

(2010) T. L. Tapley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metamorphic proteins mediate evolutionary transitions of structure

(2010) I. Yadid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering an artificial zymogen by alternate frame protein folding

(2010) D. M. Mitrea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linking folding and binding

(2009) Peter E Wright et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Shear-induced unfolding activates von Willebrand factor A2 domain for proteolysis

(2009) C. BALDAUF et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

NMR spectroscopy brings invisible protein states into focus

(2009) Andrew J Baldwin et al.   Nature Chemical Biology

Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding

(2009) Irene Díaz-Moreno et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor

(2009) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural plasticity of an acid-activated chaperone allows promiscuous substrate binding

(2009) T. L. Tapley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanoenzymatic Cleavage of the Ultralarge Vascular Protein von Willebrand Factor

(2009) X. Zhang et al.   SCIENCE

A Ca2+-Sensing Molecular Switch Based on Alternate Frame Protein Folding

(2008) Margaret M. Stratton et al.   ACS Chemical Biology

The Mad2 partial unfolding model: regulating mitosis through Mad2 conformational switching

(2008) John J. Skinner et al.   JOURNAL OF CELL BIOLOGY

Large-Scale Analysis of Thermostable, Mammalian Proteins Provides Insights into the Intrinsically Disordered Proteome

(2008) Charles A. Galea et al.   JOURNAL OF PROTEOME RESEARCH

Structure of the sulphiredoxin–peroxiredoxin complex reveals an essential repair embrace

(2008) Thomas J. Jönsson et al.   NATURE

Interconversion between two unrelated protein folds in the lymphotactin native state

(2008) Robbyn L. Tuinstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BIOCHEMISTRY: Metamorphic Proteins

(2008) A. G. Murzin   SCIENCE