A comprehensive analysis of the influence of drug binding kinetics on drug action at molecular and systems levels

Dynamic Modeling of Human 5-Lipoxygenase–Inhibitor Interactions Helps To Discover Novel Inhibitors

(2012) Yiran Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evidence for dynamics in proteins as a mechanism for ligand dissociation

(2012) Mary J Carroll et al.   Nature Chemical Biology

Conformational adaptation in drug–target interactions and residence time

(2011) Robert A Copeland   Future Medicinal Chemistry

Discovery of Dual Target Inhibitors against Cyclooxygenases and Leukotriene A4Hydrolyase

(2011) Zheng Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Shielded Hydrogen Bonds as Structural Determinants of Binding Kinetics: Application in Drug Design

(2011) Peter Schmidtke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Influence of kinetics of drug binding on EGFR signaling: A comparative study of three EGFR signaling pathway models

(2011) Sneha Bairy et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action

(2010) Georges Vauquelin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Drug–target residence time: critical information for lead optimization

(2010) Hao Lu et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Slow-Onset Inhibition of the FabI Enoyl Reductase fromFrancisella tularensis: Residence Time andin VivoActivity

(2009) Hao Lu et al.   ACS Chemical Biology

Residence Time of Receptor−Ligand Complexes and Its Effect on Biological Function

(2008) Peter J. Tummino et al.   BIOCHEMISTRY

Designing transient binding drugs: A new concept for drug discovery

(2008) Sten Ohlson   DRUG DISCOVERY TODAY

Discovery of Multitarget Inhibitors by Combining Molecular Docking with Common Pharmacophore Matching

(2008) Dengguo Wei et al.   JOURNAL OF MEDICINAL CHEMISTRY

Finding multiple target optimal intervention in disease-related molecular network

(2008) Kun Yang et al.   Molecular Systems Biology