Late-stage C–H functionalization of complex alkaloids and drug molecules via intermolecular rhodium-carbenoid insertion

Iridium-Catalyzed C–H Borylation of Heteroarenes: Scope, Regioselectivity, Application to Late-Stage Functionalization, and Mechanism

(2014) Matthew A. Larsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of Sterically Demanding Chiral Dirhodium Catalysts in Site-Selective C–H Functionalization of Activated Primary C–H Bonds

(2014) Changming Qin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemo- and site-selective derivatizations of natural products enabling biological studies

(2014) Omar Robles et al.   NATURAL PRODUCT REPORTS

Non-directed allylic C–H acetoxylation in the presence of Lewis basic heterocycles

(2014) Hasnain A. Malik et al.   Chemical Science

Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

(2013) Slava Ziegler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalyst-Controlled Aliphatic C–H Oxidations with a Predictive Model for Site-Selectivity

(2013) Paul E. Gormisky et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioconjugation by Native Chemical Tagging of C–H Bonds

(2013) Qianghui Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radical-Based Regioselective C–H Functionalization of Electron-Deficient Heteroarenes: Scope, Tunability, and Predictability

(2013) Fionn O’Hara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Industrial natural product chemistry for drug discovery and development

(2013) Armin Bauer et al.   NATURAL PRODUCT REPORTS

Translational synthetic chemistry

(2013) Sarathy Kesavan et al.   Nature Chemical Biology

Simultaneous structure–activity studies and arming of natural products by C–H amination reveal cellular targets of eupalmerin acetate

(2013) Jing Li et al.   Nature Chemistry

C–H bond activation enables the rapid construction and late-stage diversification of functional molecules

(2013) Joanna Wencel-Delord et al.   Nature Chemistry

Rhodium-catalyzed enantioselective cyclopropanation of electron-deficient alkenes

(2013) Hengbin Wang et al.   Chemical Science

CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

(2012) Junichiro Yamaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Controlled Oxidation of Remote sp3 C–H Bonds in Artemisinin via P450 Catalysts with Fine-Tuned Regio- and Stereoselectivity

(2012) Kaidong Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal-Free N–H Insertions of Donor/Acceptor Carbenes

(2012) Stephanie R. Hansen et al.   ORGANIC LETTERS

Removable Directing Groups in Organic Synthesis and Catalysis

(2011) Géraldine Rousseau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One-Step Catalytic Asymmetric Synthesis of Configurationally Stable Tröger Bases

(2011) Ankit Sharma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C–H functionalization logic in total synthesis

(2011) Will R. Gutekunst et al.   CHEMICAL SOCIETY REVIEWS

Recent developments in natural product synthesis using metal-catalysed C–H bond functionalisation

(2011) Lindsay McMurray et al.   CHEMICAL SOCIETY REVIEWS

Guiding principles for site selective and stereoselective intermolecular C–H functionalization by donor/acceptor rhodium carbenes

(2011) Huw M. L. Davies et al.   CHEMICAL SOCIETY REVIEWS

D2-Symmetric Dirhodium Catalyst Derived from a 1,2,2-Triarylcyclopropanecarboxylate Ligand: Design, Synthesis and Application

(2011) Changming Qin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Divergent C–H Functionalizations Directed by Sulfonamide Pharmacophores: Late-Stage Diversification as a Tool for Drug Discovery

(2011) Hui-Xiong Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Getting pharmaceutical R&D back on target

(2011) Mark E Bunnage   Nature Chemical Biology

Natural Products as Chemical Probes

(2010) Erin E. Carlson   ACS Chemical Biology

Rational approaches to targeted polypharmacology: creating and navigating protein–ligand interaction networks

(2010) James T Metz et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Predictable and Site-Selective Functionalization of Poly(hetero)arene Compounds by Palladium Catalysis

(2010) David Lapointe et al.   JOURNAL OF ORGANIC CHEMISTRY

Application of donor/acceptor-carbenoids to the synthesis of natural products

(2009) Huw M. L. Davies et al.   CHEMICAL SOCIETY REVIEWS

A Panel of Cytochrome P450 BM3 Variants to Produce Drug Metabolites and Diversify Lead Compounds

(2009) Andrew M. Sawayama et al.   CHEMISTRY-A EUROPEAN JOURNAL

Computational Study on the Selectivity of Donor/Acceptor-Substituted Rhodium Carbenoids

(2009) Jørn Hansen et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of (+)-11,11'-Dideoxyverticillin A

(2009) J. Kim et al.   SCIENCE

Total Syntheses of (±)-Massadine and Massadine Chloride

(2008) Shun Su et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY