Acinar cell reprogramming: a clinically important target in pancreatic disease

Prognostic Relevance of hTERT mRNA Expression in Ductal Adenocarcinoma of the Pancreas

(2015) Lukasz-Filip Grochola et al.   NEOPLASIA

Silencing of the Fibroblast growth factor 21 gene is an underlying cause of acinar cell injury in mice lacking MIST1

(2014) Charis L. Johnson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

BRCA1andBRCA2germline mutations are frequently demonstrated in both high-risk pancreatic cancer screening and pancreatic cancer cohorts

(2014) Aimee L. Lucas et al.   CANCER

Transgenerational Epigenetic Inheritance: Myths and Mechanisms

(2014) Edith Heard et al.   CELL

Epigenomic Comparison Reveals Activation of “Seed” Enhancers during Transition from Naive to Primed Pluripotency

(2014) Daniel C. Factor et al.   Cell Stem Cell

Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant

(2014) S. Denissov et al.   DEVELOPMENT

The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis

(2014) M. A. Hale et al.   DEVELOPMENT

Dynamics of genomic H3K27me3 domains and role of EZH2 during pancreatic endocrine specification

(2014) C.-R. Xu et al.   EMBO JOURNAL

A microRNA meta-signature for pancreatic ductal adenocarcinoma

(2014) Adam E Frampton et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Down-regulation of MicroRNA-494 via Loss of SMAD4 Increases FOXM1 and β-Catenin Signaling in Pancreatic Ductal Adenocarcinoma Cells

(2014) Lei Li et al.   GASTROENTEROLOGY

MicroRNA-135a Inhibits Cell Proliferation by Targeting Bmi1 in Pancreatic Ductal Adenocarcinoma

(2014) Zheng Dang et al.   International Journal of Biological Sciences

miR-212 promotes pancreatic cancer cell growth and invasion by targeting the hedgehog signaling pathway receptor patched-1

(2014) Chenchao Ma et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma

(2014) Guido von Figura et al.   NATURE CELL BIOLOGY

miR-211 Modulates Gemcitabine Activity Through Downregulation of Ribonucleotide Reductase and Inhibits the Invasive Behavior of Pancreatic Cancer Cells

(2014) Mina Maftouh et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Conversion of Human Pancreatic Acinar Cells Toward a Ductal-Mesenchymal Phenotype and the Role of Transforming Growth Factor β and Activin Signaling

(2014) Evelien De Waele et al.   PANCREAS

A Novel 2-Step Culture Model for Long-Term In Vitro Maintenance of Human Pancreatic Acinar Cells

(2014) Merja Bläuer et al.   PANCREAS

Epigenetic Reprogramming in Mist1−/− Mice Predicts the Molecular Response to Cerulein-Induced Pancreatitis

(2014) Rashid Mehmood et al.   PLoS One

Islet cell transplantation

(2014) Michael McCall et al.   Seminars in Pediatric Surgery

miR-106b-25/miR-17-92clusters: Polycistrons with oncogenic roles in hepatocellular carcinoma

(2014) Weiqi Tan   WORLD JOURNAL OF GASTROENTEROLOGY

Radionuclide labeling and evaluation of candidate radioligands for PET imaging of histone deacetylase in the brain

(2013) Young Jun Seo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cancer statistics, 2013

(2013) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

How to make a functional  -cell

(2013) F. W. Pagliuca et al.   DEVELOPMENT

Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration

(2013) F. C. Pan et al.   DEVELOPMENT

The Plastic Pancreas

(2013) Oren Ziv et al.   DEVELOPMENTAL CELL

Gene Regulatory Networks Governing Pancreas Development

(2013) H. Efsun Arda et al.   DEVELOPMENTAL CELL

Numb Regulates Acinar Cell Dedifferentiation and Survival During Pancreatic Damage and Acinar-to-Ductal Metaplasia

(2013) Renee L. Greer et al.   GASTROENTEROLOGY

Models of Acute and Chronic Pancreatitis

(2013) Markus M. Lerch et al.   GASTROENTEROLOGY

Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation

(2013) Guido von Figura et al.   GUT

Role of Notch signalling pathway in cancer and its association with DNA methylation

(2013) MADHURI G. S. AITHAL et al.   JOURNAL OF GENETICS

Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

(2013) Luc Baeyens et al.   NATURE BIOTECHNOLOGY

Transcriptional regulation by Polycomb group proteins

(2013) Luciano Di Croce et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells

(2013) Naoko Hattori et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-99 Family Targets AKT/mTOR Signaling Pathway in Dermal Wound Healing

(2013) Yi Jin et al.   PLoS One

Hypoxia Pathways and Cellular Stress Activate Pancreatic Stellate Cells: Development of an Organotypic Culture Model of Thick Slices of Normal Human Pancreas

(2013) Vinciane Rebours et al.   PLoS One

Hypermethylation of HIC1 Promoter and Aberrant Expression of HIC1/SIRT1 Might Contribute to the Carcinogenesis of Pancreatic Cancer

(2012) Gang Zhao et al.   ANNALS OF SURGICAL ONCOLOGY

Coordinated Silencing of MYC-Mediated miR-29 by HDAC3 and EZH2 as a Therapeutic Target of Histone Modification in Aggressive B-Cell Lymphomas

(2012) Xinwei Zhang et al.   CANCER CELL

Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma

(2012) Janel L. Kopp et al.   CANCER CELL

Association of increased DNA methyltransferase expression with carcinogenesis and poor prognosis in pancreatic ductal adenocarcinoma

(2012) Jing-Jing Zhang et al.   Clinical & Translational Oncology

Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells

(2012) S. Afelik et al.   DEVELOPMENT

A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation

(2012) H. P. Shih et al.   DEVELOPMENT

Bmi1 Is Required for Regeneration of the Exocrine Pancreas in Mice

(2012) Akihisa Fukuda et al.   GASTROENTEROLOGY

What We Have Learned About Pancreatic Cancer From Mouse Models

(2012) Pedro A. Pérez–Mancera et al.   GASTROENTEROLOGY

EZH2 couples pancreatic regeneration to neoplastic progression

(2012) J. Mallen-St. Clair et al.   GENES & DEVELOPMENT

Gata6is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice

(2012) Paola Martinelli et al.   GUT

Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis

(2012) Tewfik Hamidi et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of protein kinase Cδ leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1

(2012) Charis L Johnson et al.   JOURNAL OF PATHOLOGY

Global identification of transcriptional regulators of pluripotency and differentiation in embryonic stem cells

(2012) Kyoung-Jae Won et al.   NUCLEIC ACIDS RESEARCH

Autocrine Sonic Hedgehog Attenuates Inflammation in Cerulein-Induced Acute Pancreatitis in Mice via Upregulation of IL-10

(2012) Xiangyu Zhou et al.   PLoS One

Adenosine kinase inhibition selectively promotes rodent and porcine islet  -cell replication

(2012) J. P. Annes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mind bomb 1 is required for pancreatic  -cell formation

(2012) S. Horn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

(2012) K. Xu et al.   SCIENCE

Exocrine ontogenies: On the development of pancreatic acinar, ductal and centroacinar cells

(2012) Megan H. Cleveland et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Notch1 intracellular domain increases cytoplasmic EZH2 levels during early megakaryopoiesis

(2012) A Roy et al.   Cell Death & Disease

Notch signaling in the pancreas: patterning and cell fate specification

(2012) Solomon Afelik et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Carcinogenesis of Intraductal Papillary Mucinous Neoplasm of the Pancreas: Loss of MicroRNA-101 Promotes Overexpression of Histone Methyltransferase EZH2

(2011) Osamu Nakahara et al.   ANNALS OF SURGICAL ONCOLOGY

Drinking and driving pancreatitis

(2011) Aurelia Lugea et al.   Autophagy

Histone deacetylase 1 is required for exocrine pancreatic epithelial proliferation in development and cancer

(2011) Weiqiang Zhou et al.   CANCER BIOLOGY & THERAPY

Suppression of Ptf1a Activity Induces Acinar-to-Endocrine Conversion

(2011) Daniel Hesselson et al.   CURRENT BIOLOGY

Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism

(2011) J. Ahnfelt-Ronne et al.   DEVELOPMENT

Identification of cis regulatory features in the embryonic zebrafish genome through large-scale profiling of H3K4me1 and H3K4me3 binding sites

(2011) Aaron W. Aday et al.   DEVELOPMENTAL BIOLOGY

Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas

(2011) Daniel Kopinke et al.   DEVELOPMENTAL BIOLOGY

H3K4 tri-methylation provides an epigenetic signature of active enhancers

(2011) Aleksandra Pekowska et al.   EMBO JOURNAL

Lineage Tracing Evidence for Transdifferentiation of Acinar to Duct Cells and Plasticity of Human Pancreas

(2011) Isabelle Houbracken et al.   GASTROENTEROLOGY

DNMT3B gene amplification predicts resistance to DNA demethylating drugs

(2011) Laia Simó-Riudalbas et al.   GENES CHROMOSOMES & CANCER

Pancreatic ductal adenocarcinoma and acinar cells: a matter of differentiation and development?

(2011) Ilse Rooman et al.   GUT

BMI1 Is Recruited to DNA Breaks and Contributes to DNA Damage-Induced H2A Ubiquitination and Repair

(2011) V. Ginjala et al.   MOLECULAR AND CELLULAR BIOLOGY

Context-Specific Regulation of NF-κB Target Gene Expression by EZH2 in Breast Cancers

(2011) Shuet Theng Lee et al.   MOLECULAR CELL

Clinical Potential of MicroRNAs in Pancreatic Ductal Adenocarcinoma

(2011) Colin W. Steele et al.   PANCREAS

Targeting Epigenetic Regulation of miR-34a for Treatment of Pancreatic Cancer by Inhibition of Pancreatic Cancer Stem Cells

(2011) Dara Nalls et al.   PLoS One

The Absence of MIST1 Leads to Increased Ethanol Sensitivity and Decreased Activity of the Unfolded Protein Response in Mouse Pancreatic Acinar Cells

(2011) Sruthi Alahari et al.   PLoS One

Expression of DNMT1 and DNMT3a Are Regulated by GLI1 in Human Pancreatic Cancer

(2011) ShanShan He et al.   PLoS One

Chromatin "Prepattern" and Histone Modifiers in a Fate Choice for Liver and Pancreas

(2011) C.-R. Xu et al.   SCIENCE

Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detection

(2010) Sara Raimondi et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Pancreatic Cancers Epigenetically Silence SIP1 and Hypomethylate and Overexpress miR-200a/200b in Association with Elevated Circulating miR-200a and miR-200b Levels

(2010) A. Li et al.   CANCER RESEARCH

Differentiation of Pancreatic Acinar Cells to Hepatocytes Requires an Intermediate Cell Type

(2010) Sung–Yu Wu et al.   GASTROENTEROLOGY

Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program

(2010) J. van Arensbergen et al.   GENOME RESEARCH

Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis

(2010) A. V. Pinho et al.   GUT

Implications of enhancer of zeste homologue 2 expression in pancreatic ductal adenocarcinoma

(2010) Adam D. Toll et al.   HUMAN PATHOLOGY

Dexamethasone Treatment Induces the Reprogramming of Pancreatic Acinar Cells to Hepatocytes and Ductal Cells

(2010) Amani Al-Adsani et al.   PLoS One

Delivering the Lateral Inhibition Punchline: It's All About the Timing

(2010) J. D. Axelrod   Science Signaling

AR42J-B-13 cell: An expandable progenitor to generate an unlimited supply of functional hepatocytes

(2010) Karen Wallace et al.   TOXICOLOGY

Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras

(2009) Catherine Carrière et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration

(2009) Ryan M. Anderson et al.   DEVELOPMENTAL BIOLOGY

Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth

(2009) Myriam Solar et al.   DEVELOPMENTAL CELL

Ras Activity Levels Control the Development of Pancreatic Diseases

(2009) Baoan Ji et al.   GASTROENTEROLOGY

Fibroblast Growth Factor 21 Reduces the Severity of Cerulein-Induced Pancreatitis in Mice

(2009) Charis L. Johnson et al.   GASTROENTEROLOGY

Notch Signaling as Gatekeeper of Rat Acinar-to-β-Cell Conversion in Vitro

(2009) Luc Baeyens et al.   GASTROENTEROLOGY

Salivary Transcriptomic Biomarkers for Detection of Resectable Pancreatic Cancer

(2009) Lei Zhang et al.   GASTROENTEROLOGY

Polycomb protein Ezh2 regulates pancreatic  -cell Ink4a/Arf expression and regeneration in diabetes mellitus

(2009) H. Chen et al.   GENES & DEVELOPMENT

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma

(2009) Carles Martínez-Romero et al.   JOURNAL OF PATHOLOGY

Exocrine pancreas trans-differentiation to hepatocytes—A physiological response to elevated glucocorticoid in vivo

(2009) Karen Wallace et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Regulation of the Drosophila engrailed gene by Polycomb repressor complex 2

(2009) Sa Chen et al.   MECHANISMS OF DEVELOPMENT

A small molecule that directs differentiation of human ESCs into the pancreatic lineage

(2009) Shuibing Chen et al.   Nature Chemical Biology

Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis

(2009) E. Sangiorgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Constitutive Active/Androstane Receptor Facilitates Unique Phenobarbital-Induced Expression Changes of Genes Involved in Key Pathways in Precancerous Liver and Liver Tumors

(2009) Jennifer M. Phillips et al.   TOXICOLOGICAL SCIENCES

Organ-specific requirements for Hdac1 in liver and pancreas formation

(2008) Emily S. Noël et al.   DEVELOPMENTAL BIOLOGY

Histone deacetylase 3 (hdac3) is specifically required for liver development in zebrafish

(2008) Muhammad Farooq et al.   DEVELOPMENTAL BIOLOGY

Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells

(2008) Jared S. Burlison et al.   DEVELOPMENTAL BIOLOGY

Pancreatic Inactivation of c-Myc Decreases Acinar Mass and Transdifferentiates Acinar Cells Into Adipocytes in Mice

(2008) Claire Bonal et al.   GASTROENTEROLOGY

Multiple genes are hypermethylated in intraductal papillary mucinous neoplasms of the pancreas

(2008) Seung-Mo Hong et al.   MODERN PATHOLOGY

Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms

(2008) Raphael Margueron et al.   MOLECULAR CELL

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

(2008) J.-P. De La O et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice

(2008) N. Habbe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

(2008) S. Varambally et al.   SCIENCE