Article
Gastroenterology & Hepatology
Michelle M. Cooley, Diana D. H. Thomas, Kali Deans, Yajing Peng, Aurelia Lugea, Stephen J. Pandol, Luigi Puglielli, Guy E. Groblewski
Summary: The study demonstrated that down-regulation of AT-1 during pancreatitis leads to chronic ER stress and pancreatic inflammation. Loss of AT-1 induces activation of unfolded protein response pathways and causes pancreatic disease characterized by intracellular trypsin accumulation, immune cell infiltration, and fibrosis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Isidoro Cobo, Sumit Paliwal, Cristina Bodas, Irene Felipe, Julia Melia-Aloma, Ariadna Torres, Jaime Martinez-Villarreal, Marina Malumbres, Fernando Garcia, Irene Millan, Natalia del Pozo, Joo-Cheol Park, Ray J. MacDonald, Javier Munoz, Raul Mendez, Francisco X. Real
Summary: NFIC is a transcription factor that regulates the function of pancreatic acinar cells and suppresses the development of pancreatic ductal adenocarcinoma. It controls the differentiation and physiological functions of pancreatic acinar cells by regulating the expression of acinar genes, including those involved in RNA and protein metabolism, as well as the genes involved in resolving endoplasmic reticulum stress. In pancreatic cancer, NFIC expression is down-regulated, leading to the formation of pre-neoplastic lesions driven by mutant KRAS.
NATURE COMMUNICATIONS
(2023)
Article
Cell & Tissue Engineering
Zhengyu Jiang, Feijing Wu, Pasquale Laise, Tanaka Takayuki, Fu Na, Woosook Kim, Hiroki Kobayashi, Wenju Chang, Ryota Takahashi, Giovanni Valenti, Masaki Sunagawa, Ruth A. White, Marina Macchini, Bernhard W. Renz, Moritz Middelhoff, Yoku Hayakawa, Zinaida A. Dubeykovskaya, Xiangtian Tan, Timothy H. Chu, Karan Nagar, Yagnesh Tailor, Bryana R. Belin, Akanksha Anand, Samuel Asfaha, Michael O. Finlayson, Alina C. Iuga, Andrea Califano, Timothy C. Wang
Summary: Although it was believed that adult pancreatic stem cells do not exist, it is now known that the acinar compartment contains progenitor cells, including tissue-repairing facultative progenitors. This study focuses on a pancreatic acinar population marked by the expression of trefoil factor 2 (Tff2). It is found that Tff2 defines a transit-amplifying progenitor population that contributes to normal homeostasis and protects against Kras-driven carcinogenesis.
Article
Ecology
Kelly A. Heilman, Valerie M. Trouet, Soumaya Belmecheri, Neil Pederson, Melissa A. Berke, Jason S. McLachlan
Summary: Increases in temperature and changes in precipitation can limit tree growth, but rising CO2 levels may offset some of these impacts through increased plant Water Use Efficiency. However, interactions between summer temperatures and precipitation could diminish the water-savings benefits, leading to potential growth declines under hot and dry conditions. Overall, while higher intrinsic Water Use Efficiency may provide some benefits, future temperature increases combined with drought events could still drive significant growth declines.
Article
Veterinary Sciences
Aritada Yoshimura, Takahiro Ohmori, Daiki Hirao, Miori Kishimoto, Tomoko Iwanaga, Naoki Miura, Kazuhiko Suzuki, Ryuji Fukushima
Summary: This study investigated the relationship between cardiac function, pancreatic blood flow (PBF), and histopathological changes in pancreatic acinar cells. The findings showed that the decrease in PBF caused by cardiac dysfunction directly led to pancreatic acinar cell atrophy. Maintaining PBF is clinically important for treating dogs with heart failure, and these findings provide a reliable basis for developing new therapeutic strategies, such as pancreatic protection, for heart failure in dogs.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jaeeun Lee, Joo Weon Lim, Hyeyoung Kim
Summary: Excessive alcohol intake leads to the accumulation of fatty acid ethyl esters in the pancreas, causing pancreatic cell injury and alcoholic pancreatitis. Lycopene inhibits NADPH oxidase-mediated ROS production, preventing damage induced by ethanol and fatty acids in pancreatic cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Xingzheng Li, Jianlou Song, Xuefeng Shi, Mingyi Huang, Lei Liu, Guoqiang Yi, Ning Yang, Guiyun Xu, Jiangxia Zheng
Summary: The study revealed the crucial roles of liver FMO3 and cecal microbes in TMA metabolism in ducks, with the limited oxidation ability of FMO3 explaining the weakening of TMA metabolism in ducks.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Pornthip Chaichompoo, Ramaneeya Nithipongvanitch, Wasinee Kheansaard, Alisa Tubsuwan, Kanitta Srinoun, Jim Vadolas, Suthat Fucharoen, Duncan R. Smith, Pranee Winichagoon, Saovaros Svasti
Summary: Beta-thalassaemia is characterized by defective beta-globin production, leading to ineffective erythropoiesis. Increased autophagy and decreased apoptosis were observed in beta-thalassaemic erythroblasts. This imbalance may contribute to the ineffective erythropoiesis in beta-thalassaemia.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Ji-fang Yu, Jin-tian Xu, Shan-shan Yang, Mei-na Gao, Hao-rui Si, Dong-yan Xiong, Jing Gu, Zhi-long Wu, Jie Zhou, Jiao-yu Deng
Summary: This study identified a methylenetetrahydrofolate reductase (MTHFR) in Mycobacterium tuberculosis and found that its activity is associated with susceptibility to antifolate drugs. These findings have significant implications for the design of antitubercular drugs to treat drug-resistant tuberculosis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Gastroenterology & Hepatology
Huaxun Wu, Hui Li, Wen Wen, Yongchao Wang, Hong Xu, Mei Xu, Jacqueline A. Frank, Wei Wei, Jia Luo
Summary: The study demonstrated that MANF could alleviate alcohol-induced ER stress and cell death in pancreatic acinar cells, indicating its potential therapeutic value for alcoholic pancreatitis.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2021)
Article
Surgery
Catherine G. Tran, Aaron T. Scott, Guiying Li, Scott K. Sherman, Po Hien Ear, James R. Howe
Summary: Metastatic pancreatic neuroendocrine tumors have lower expression of somatostatin compared to primary tumors, and knocking down somatostatin can increase cell growth and metabolic activity. This phenomenon may be attributed to increased activation of Akt.
Article
Biochemistry & Molecular Biology
Jaeeun Lee, Joo Weon Lim, Hyeyoung Kim
Summary: Alcohol increases gut permeability, leading to pancreatic damage. Ethanol or LPS treatment increases ROS production. Lycopene inhibits IL-6 expression and reduces ROS levels through the Nrf2 pathway.
Article
Geosciences, Multidisciplinary
Jialei Zhu, Joyce E. Penner, Anne Garnier, Olivier Boucher, Meng Gao, Lei Song, Junjun Deng, Cong-qiang Liu, Pingqing Fu
Summary: Travel restrictions during the COVID-19 pandemic resulted in a significant decrease in global flight mileage. Observations show an increase in ice crystal concentrations in cirrus clouds, attributed to reduced soot emissions from aircraft. If aircraft traffic continues to decrease, there will be a small positive radiative effect globally.
Article
Biochemistry & Molecular Biology
Marthe-Susanna Wegner, Nina Schomel, Ellen M. Olzomer, Sandra Trautmann, Catherine Olesch, Frances L. Byrne, Bernhard Brune, Robert Gurke, Nerea Ferreiros, Andreas Weigert, Gerd Geisslinger, Kyle L. Hoehn
Summary: Hepatocellular carcinoma (HCC) is challenging to treat due to late diagnosis and multidrug resistance, leading to poor outcomes. Increasing UGCG expression in liver cells affects mitochondrial respiration and glycolysis, decreasing tumor markers and proliferation, indicating varied outcomes in different cancer types with increased GlcCer expression.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Genetics & Heredity
Aurelie Dewaele, Emilie Dujardin, Marjolaine Andre, Audrey Albina, Helene Jammes, Frank Giton, Eli Sellem, Genevieve Jolivet, Eric Pailhoux, Maelle Pannetier
Summary: This study investigates the role of estrogens in male reproductive system using a rabbit model. The findings suggest that testicular estrogens may be involved in sperm development and acquisition of motility.
Article
Endocrinology & Metabolism
Julia M. Assini, Erin E. Mulvihill, Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Sanjiv S. Chhoker, Cynthia G. Sawyez, Maria Drangova, Andrew C. Adams, Alexei Kharitonenkov, Christopher L. Pin, Murray W. Huff
Article
Genetics & Heredity
Paxton M. Moon, Silvia Penuela, Kevin Barr, Sami Khan, Christopher L. Pin, Ian Welch, Mukundan Attur, Steven B. Abramson, Dale W. Laird, Frank Beier
JOURNAL OF MOLECULAR MEDICINE-JMM
(2015)
Review
Genetics & Heredity
Christopher L. Pin, Joanna F. Ryan, Rashid Mehmood
Article
Cell Biology
Melissa A. Fenech, Caitlin M. Sullivan, Lucimar T. Ferreira, Rashid Mehmood, William A. Macdonald, Peter B. Stathopulos, Christopher L. Pin
JOURNAL OF CELLULAR PHYSIOLOGY
(2016)
Article
Cell Biology
Michelle Kim, Perri Deacon, Rommel G. Tirona, Richard B. Kim, Christopher L. Pin, Henriette E. Meyer zu Schwabedissen, Rennian Wang, Ute I. Schwarz
HISTOCHEMISTRY AND CELL BIOLOGY
(2017)
Article
Cell Biology
Elena N. Fazio, Claire C. Young, Jelena Toma, Michael Levy, Kurt R. Berger, Charis L. Johnson, Rashid Mehmood, Patrick Swan, Alphonse Chu, Sean P. Cregan, F. Jeffrey Dilworth, Christopher J. Howlett, Christopher L. Pin
MOLECULAR BIOLOGY OF THE CELL
(2017)
Article
Biochemistry & Molecular Biology
David L. Marks, Rachel L. Olson, Raul Urrutia, Daniel D. Billadeau, Nilotpal Roy, George A. Calin, Muller Fabbri, Marina Koutsioumpa, Dimitrios Iliopoulos, Tamas Ordog, Robert Huebert, Olga Sarmento, Adebowale O. Bamidele, William Faubion, Gwen L. Lomberk, Jens Siveke, Nita Ahuja, Juan Iovanna, Ryan A. Hlady, Keith Robertson, John Kisiel, Christopher L. Pin, Martin E. Fernandez-Zapico
Article
Endocrinology & Metabolism
Aijun Zhang, Douglas H. Sieglaff, Jean Philippe York, Ji Ho Suh, Stephen D. Ayers, Glenn E. Winnier, Alexei Kharitonenkov, Christopher Pin, Pumin Zhang, Paul Webb, Xuefeng Xia
JOURNAL OF ENDOCRINOLOGY
(2015)
Article
Chemistry, Medicinal
Lihai Yu, Nikola Despotovic, Michael S. Kovacs, Christopher L. Pin, Leonard G. Luyt
ACS MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Gastroenterology & Hepatology
Yongde Luo, Yaying Yang, Muyun Liu, Dan Wang, Feng Wang, Yawei Bi, Juntao Ji, Suyun Li, Yan Liu, Rong Chen, Haojie Huang, Xiaojie Wang, Agnieszka K. Swidnicka-Siergiejko, Tobias Janowitz, Semir Beyaz, Guoqiang Wang, Sulan Xu, Agnieszka B. Bialkowska, Catherine K. Luo, Christoph L. Pin, Guang Liang, Xiongbin Lu, Maoxin Wu, Kenneth R. Shroyer, Robert A. Wolff, William Plunkett, Baoan Ji, Zhaoshen Li, Ellen Li, Xiaokun Li, Vincent W. Yang, Craig D. Logsdon, James L. Abbruzzese, Weiqin Lu
Article
Biochemistry & Molecular Biology
Melissa A. Fenech, McKenzie M. Carter, Peter B. Stathopulos, Christopher L. Pin
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2020)
Article
Gastroenterology & Hepatology
M. Teresa Borrello, Mickenzie B. Martin, Christopher L. Pin
Summary: Pancreatitis and pancreatic ductal adenocarcinoma are diseases involving genetic and environmental factors, and the unfolded protein response (UPR) plays a crucial role in the pancreas. Increased UPR activity is associated with acute injury and risk factors related to these diseases. Targeting the UPR can have significant implications for the treatment of pancreatitis and pancreatic cancer.
Article
Multidisciplinary Sciences
Moritz Binder, Ryan M. Carr, Terra L. Lasho, Christy M. Finke, Abhishek A. Mangaonkar, Christopher L. Pin, Kurt R. Berger, Amelia Mazzone, Sandeep Potluri, Tamas Ordog, Keith D. Robertson, David L. Marks, Martin E. Fernandez-Zapico, Alexandre Gaspar-Maia, Mrinal M. Patnaik
Summary: Mutations in the chromatin remodeler ASXL1 are associated with poor clinical outcome in chronic myelomonocytic leukemia (CMML). This study investigates the impact of these mutations on gene expression and chromatin remodeling, and reveals that ASXL1 mutations lead to abnormal chromatin dynamics, affecting gene expression and accessibility of key regulatory elements.
NATURE COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Claire C. Young, Ryan M. Baker, Christopher J. Howlett, Todd Hryciw, Joshua E. Herman, Douglas Higgs, Richard Gibbons, Howard Crawford, Arthur Brown, Christopher L. Pin
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Article
Pharmacology & Pharmacy
Sarah J. Woolsey, Melanie D. Beaton, Sara E. Mansell, Matilde Leon-Ponte, Janice Yu, Christopher L. Pin, Paul C. Adams, Richard B. Kim, Rommel G. Tirona
MOLECULAR PHARMACOLOGY
(2016)