Article
Biochemistry & Molecular Biology
Roberta Gonnella, Maria Saveria Gilardini Montani, Luisa Guttieri, Maria Anele Romeo, Roberta Santarelli, Mara Cirone
Summary: This study demonstrates the crucial role of the IRE1α/XBP1 axis in the survival of PEL cells, with minor influence from PERK and ATF6, and the ability of the IRE1α/XBP1 axis to induce the release of IL-6, IL-10, and VEGF. Additionally, IRE1α/XBP1 inhibition reduces STAT3 phosphorylation and induces pro-survival autophagy in PEL cells, suggesting that targeting this axis may be a promising strategy against PEL cells.
Editorial Material
Endocrinology & Metabolism
Shirin Geravandi, Amin Ardestani
Summary: This study reveals that aberrant crosstalk between acinar cells and beta cells in the pancreas has a detrimental effect on the viability of beta cells in type 2 diabetes.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Cell Biology
Yalan Jiang, Zehua Tao, Hua Chen, Sheng Xia
Summary: The endoplasmic reticulum quality control system plays a crucial role in immune cells, maintaining protein homeostasis and ensuring normal development and function of immune cells. Imbalance in ER homeostasis may impact immune responses, suggesting new therapeutic targets for immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Sujata Saraswat Ohri, Russell M. Howard, Yu Liu, Kariena R. Andres, Courtney T. Shepard, Michal Hetman, Scott R. Whittemore
Summary: The endoplasmic reticulum stress response (ERSR) is activated in neurodegenerative diseases and CNS traumatic injuries, involving three major components - PERK, IRE-1, and activating transcription factor-6. The XBP1-mediated UPR signaling pathway plays a crucial role in restoring ER homeostasis in oligodendrocytes and enhancing white matter sparing and functional recovery post-spinal cord injury.
Article
Environmental Sciences
Xiaoyu Wang, Fan Yang, Xiaomin Tian, Haihua Huo, Xinrun Li, Haitong Wu, Jianying Guo
Summary: Excessive copper can cause histopathological damage to duck cerebrums, disrupt the balance of trace elements, induce oxidative stress and activation of ER quality control, resulting in duck cerebrums damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Lea Daverkausen-Fischer, Margarethe Draga, Felicitas Proels
Summary: The endoplasmic reticulum (ER) plays a central role in protein folding and secretion. BiP and ERdj proteins are important chaperones in the ER, assisting in the folding process and regulating protein synthesis, translocation, and degradation. Dysfunction of these proteins can lead to the accumulation of unfolded proteins and the development of metabolic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Lea Daverkausen-Fischer, Felicitas Proels
Summary: The accumulation of misfolded proteins in the endoplasmic reticulum triggers a cellular response known as the unfolded protein response (UPR), which is primarily controlled by three transmembrane proteins IRE1 alpha, ATF6, and PERK, with the activity regulated by the ER-resident Hsp70 protein BiP. The co-chaperone ERDJ4 plays a central role in controlling lipogenesis and protein synthesis by promoting the degradation of SREBP1c and the assembly of the protein complex mTORC2, as well as regulating epithelial-to-mesenchymal transition and cellular survival in stressed cells.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Neurosciences
Shuangchan Wu, Sarrabeth Stone, Yuan Yue, Wensheng Lin
Summary: The integrated UPR and ERAD mechanisms are essential for maintaining ER homeostasis and the viability of mature SCs in the peripheral nervous system. Sel1L deficiency in SCs leads to ER stress and UPR activation, impacting mature SCs but not actively myelinating SCs during development.
Article
Biochemistry & Molecular Biology
Rossella Benedetti, Andrea Arena, Maria Anele Romeo, Maria Saveria Gilardini Montani, Roberta Gonnella, Roberta Santarelli, Pankaj Trivedi, Mara Cirone
Summary: This study found that inhibiting the IRE1 alpha/XBP1 axis had a stronger cytotoxic effect on Burkitt lymphoma (BL) cells, correlated with c-Myc downregulation. In addition, inhibition of IRE1 alpha/XBP1 also downregulated BRCA-1 and RAD51 expression, and enhanced the cytotoxicity of PARP inhibitor against BL cells and Primary Effusion Lymphoma (PEL). These findings suggest a new therapeutic opportunity for treating aggressive B-cell lymphomas by combining inhibition of UPR sensors and molecules involved in DNA damage response (DDR).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Shuangchan Wu, Wensheng Lin
Summary: Endoplasmic reticulum associated degradation (ERAD) is responsible for recognizing and degrading unfolded or misfolded proteins in the ER. Sel1L is essential for the ERAD activity and its knockout in mature myelinating cells caused myelin abnormalities in the adult CNS and PNS. The knockout impaired ERAD, leading to ER stress and UPR activation, and suppressed myelin protein translation, resulting in myelin thinning and demyelination in the adult CNS and PNS.
Article
Immunology
Yangyang Zhu, Lei Liu, Chuchu Zhang, Chao Zhang, Tingting Han, Renjie Duan, Yiheng Jin, Huimin Guo, Kan She, Yihua Xiao, Akira Goto, Qingshuang Cai, Shanming Ji
Summary: In Drosophila, the endoplasmic reticulum-associated protein degradation (ERAD) is involved in regulating various biological processes. This study found that ERAD plays a role in mediating the Toll innate immune response, but not the IMD immune response in fly fat bodies. The gene Me31B was identified to have a functional role in ERAD-mediated immune defense. Additionally, the study showed that silencing Xbp1 partially rescued the immune defects caused by dysregulated ERAD. These findings highlight the essential function of ERAD in the Toll immune reaction in Drosophila.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Gastroenterology & Hepatology
Luis Fernando Calimano-Ramirez, Taher Daoud, Dheeraj Reddy Gopireddy, Ajaykumar C. Morani, Rebecca Waters, Kazim Gumus, Albert Russell Klekers, Priya R. Bhosale, Mayur K. Virarkar
Summary: Acinar cell carcinoma is a rare pancreatic malignancy with distinctive features. Surgical resection is the preferred treatment, but precision medicine breakthroughs may lead to targeted therapies. There are currently no standard treatment protocols for patients who cannot undergo surgical resection.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Biology
Adam Read, Martin Schroeder
Summary: The unfolded protein response (UPR) is a cellular mechanism for maintaining protein folding balance in the endoplasmic reticulum. It is activated when unfolded proteins accumulate, leading to an increased load on folding molecules. The UPR works to reduce the number of unfolded proteins through various pathways, and if successful, restores protein folding balance; however, failure can potentially result in cell death.
Article
Oncology
Paul R. Burchard, Alexander C. Chacon, Alexa Melucci, Anthony S. Casabianca, Subir Goyal, Jeffrey M. Switchenko, Shishir K. Maithel, David A. Kooby, Darren R. Carpizo, Mihir M. Shah
Summary: In resectable PACC, adjuvant therapy provides a survival benefit limited to pathologic stage IIB disease.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Cell Biology
Ming Yang, Shilu Luo, Xi Wang, Chenrui Li, Jinfei Yang, Xuejing Zhu, Li Xiao, Lin Sun
Summary: The endoplasmic reticulum (ER) is crucial for maintaining cellular homeostasis, and ER-phagy, a selective form of autophagy, helps remove damaged ER to protect cells from harm caused by excessive ER stress. Many receptor-mediated ER-phagy pathways have been discovered in recent years, highlighting the importance of this newly identified autophagy process in maintaining cellular health.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Monica Dalva, Ida K. Lavik, Khadija El Jellas, Anny Gravdal, Aurelia Lugea, Stephen J. Pandol, Pal R. Njolstad, Richard T. Waldron, Karianne Fjeld, Bente B. Johansson, Anders Molven
Editorial Material
Oncology
Richard T. Waldron, Aurelia Lugea, Stephen J. Pandol
ANNALS OF TRANSLATIONAL MEDICINE
(2019)
Article
Oncology
Mingtian Che, Soo-Mi Kweon, Jia-Ling Teo, Yate-Ching Yuan, Laleh G. Melstrom, Richard T. Waldron, Aurelia Lugea, Raul A. Urrutia, Stephen J. Pandol, Keane K. Y. Lai
Review
Gastroenterology & Hepatology
Zobeida Cruz-Monserrate, Kristyn Gumpper, Valentina Pita, Phil A. Hart, Christopher Forsmark, David C. Whitcomb, Dhiraj Yadav, Richard T. Waldron, Stephen Pandol, Hanno Steen, Vincent Anani, Natasha Kanwar, Santhi Swaroop Vege, Savi Appana, Liang Li, Jose Serrano, Jo Ann S. Rinaudo, Mark Topazian, Darwin L. Conwell
Summary: Chronic pancreatitis lacks diagnostic or prognostic biomarkers, but potential candidates have been identified. Five biomarkers showed high effectiveness in distinguishing CP cases, while 30 had moderate effectiveness. Variability in study design, criteria, and sample handling was noted, suggesting the need for standardized approaches in future research.
Letter
Gastroenterology & Hepatology
Marc T. Goodman, Simon K. Lo, Dhiraj Yadav, Bechien U. Wu, Laith H. Jamil, Karl K. Kwok, Georgios I. Papachristou, Elham Afghani, Yunhee Choi-Kuaea, Richard T. Waldron, Christina Lombardi, Christie Y. Jeon, Irene B. Helenowski, Ellen Richmond, Kelly Benante, Aida Habtezion, Tia Schering, Seema A. Khan, Luz M. Rodriguez, Stephen J. Pandol
Article
Biochemistry & Molecular Biology
Cheng Hu, Liyuan Yin, Zhiyao Chen, Richard T. Waldron, Aurelia Lugea, Yiyun Lin, Xiaoqian Zhai, Li Wen, Yuan-Ping Han, Stephen J. Pandol, Lihui Deng, Qing Xia
Summary: Chronic pancreatitis (CP) is closely related to irreversible fibro-inflammatory changes induced by pancreatic stellate cells (PSC), which have unique transcriptional profiles. Some genes in PSC may serve as biomarkers for CP.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Meeting Abstract
Gastroenterology & Hepatology
C. Hu, L. Yin, Z. Chen, R. T. Waldron, A. Lugea, Y. Lin, X. Zhai, Y. Han, S. J. Pandol, L. Deng, Q. Xia
Meeting Abstract
Gastroenterology & Hepatology
C. Hu, R. T. Waldron, C. Quiros, Q. Xia, B. Ji, S. J. Pandol, A. Lugea
Meeting Abstract
Gastroenterology & Hepatology
R. T. Waldron, A. Lugea, S. Parker, J. Van Eyk, G. I. Papachristou, S. J. Pandol
Meeting Abstract
Gastroenterology & Hepatology
R. T. Waldron, A. Lugea, L. Huo, P. Yue, J. Turkson, S. J. Pandol
Meeting Abstract
Gastroenterology & Hepatology
J. Wang, J. Wan, O. Wang, M. Jaggarapu, A. Haddock, R. T. Waldron, A. Lugea, S. J. Pandol, Y. Wang, Y. Bi, B. Ji
Meeting Abstract
Gastroenterology & Hepatology
R. T. Waldron, A. Lugea, K. Stello, G. I. Papachristou, S. J. Pandol
Review
Physiology
Qiong Wei, Liang Qi, Hao Lin, Dechen Liu, Xiangyun Zhu, Yu Dai, Richard T. Waldron, Aurelia Lugea, Mark O. Goodarzi, Stephen J. Pandol, Ling Li
FRONTIERS IN PHYSIOLOGY
(2020)
Review
Physiology
Mengmeng Zhi, Xiangyun Zhu, Aurelia Lugea, Richard T. Waldron, Stephen J. Pandol, Ling Li
FRONTIERS IN PHYSIOLOGY
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Mengmeng Zhi, Richard Waldron, Hsin-Yuan Su, Cheng Hu, Ling Li, Stephen J. Pandol, Aurelia Lugea