Review
Oncology
Federico Selvaggi, Eugenia Melchiorre, Ilaria Casari, Sebastiano Cinalli, Massimiliano Cinalli, Gitana Maria Aceto, Roberto Cotellese, Ingrid Garajova, Marco Falasca
Summary: Pancreatic ductal adenocarcinoma is highly threatening and characterized by perineural invasion (PNI), which is associated with recurrence, poor prognosis, and pain. Researchers are currently seeking more effective therapies to inhibit the nerve invasion promoted by pancreatic ductal adenocarcinoma.
Article
Pathology
A. Handra-Luca
Summary: The study focused on the expression patterns of AKT and mTOR proteins in PDAC, revealing their correlations with tumor features and other pathway proteins. The results suggest an intricate role of mTOR in cell proliferation and tumor development in PDAC. Interactions between AKT and mTOR with MAPK and SMAD pathway proteins may impact cell proliferation and tumor behavior at various levels within the protein framework.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Christian Vay, Shahrooz Babaei, Sami-Alexander Safi, Levent Dizdar, Alexander Rehders, Lena Haeberle, Christoph Roderburg, Sven H. Loosen, Irene Esposito, Wolfram T. Knoefel, Andreas Krieg
Summary: This study analyzed the expression of the apoptosis inhibitor protein survivin in pancreatic ductal adenocarcinoma (PDAC) and found that it is significantly correlated with disease progression and prognosis. The findings suggest that survivin can be used as a biomarker to evaluate the aggressiveness of PDAC and as a potential therapeutic target.
Article
Microbiology
Kelley N. L. McKinley, Kelly M. Herremans, Andrea N. Riner, Vignesh Vudatha, Devon C. Freudenberger, Steven J. Hughes, Eric W. Triplett, Jose G. Trevino
Summary: This study explores the relationship between the oral and tumor microbiomes in patients with pancreatic ductal adenocarcinoma (PDAC). It reveals a high prevalence and relative abundance of oral bacteria, particularly Veillonella and Streptococcus, in tumor tissue. The most prevalent and abundant taxon, Veillonella atypica, was cultured from patient saliva, sequenced and annotated, identifying genes that may contribute to tumorigenesis. The sequence similarity between patient matched saliva and tumor tissue suggests that the microbiota in PDAC tumors may originate from the mouth. These findings may have clinical implications for the care and treatment of PDAC patients.
Article
Oncology
Justin M. Lebenthal, Junting Zheng, Paul M. Glare, Eileen M. O'Reilly, Andrew C. Yang, Andrew S. Epstein
Summary: The Memorial Sloan Kettering Prognostic Score (MPS), consisting of the neutrophil-lymphocyte ratio (NLR) and albumin levels, is a predictive tool for survival in patients with metastatic pancreatic adenocarcinoma (mPDAC) regardless of performance status, disease characteristics, and cancer therapy. Higher MPS scores, liver metastases, radiation therapy, hospital admissions, thromboembolism, and performance status were associated with worse overall survival in this study.
Article
Cell Biology
Maria Dobre, Vlad Herlea, Catalina Vladut, Mihai Ciocirlan, Vasile Daniel Balaban, Gabriel Constantinescu, Mircea Diculescu, Elena Milanesi
Summary: The study identified a panel of downregulated miRNAs in PDAC tissue, which could serve as potential therapeutic targets for the development of new miRNA-based therapies for PDAC.
Article
Oncology
Yoshiki Naito, Jun Akiba, Yoshinao Kinjo, Eiji Sadashima, Toshiro Ogata, Yuta Yano, Masakio Tanigawa, Masamichi Nakayama, Akihiko Kawahara, Yoshinobu Okabe, Hisamune Sakai, Toru Hisaka, Yoshito Akagi, Hirohisa Yano
Summary: This study investigates the utility of sulphite oxidase (SUOX) expression as a prognostic factor in pancreatic adenocarcinoma (PDAC). The results suggest that high SUOX expression is associated with a significantly poorer prognosis, indicating its potential as a novel prognostic biomarker.
ANTICANCER RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Gaetan-Romain Joliat, Ismail Labgaa, Jerome Gilgien, Nicolas Demartines
Summary: The time to surgery in patients undergoing pancreatoduodenectomy for PDAC does not significantly impact overall survival or recurrence-free survival. Only lymph node invasion and adjuvant chemotherapy are associated with OS in these patients.
Review
Oncology
Tarak Chouari, Francesca Soraya La Costa, Nabeel Merali, Maria-Danae Jessel, Shivan Sivakumar, Nicola Annels, Adam E. Frampton
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a challenging cancer to treat due to late detection, lack of effective screening tests, and resistance to standard treatments. Immunotherapy has emerged as a potential solution, stimulating the immune system to fight cancer cells. This paper summarizes studies on immunotherapies in PDAC, discusses their limitations, and explores avenues for future research.
Article
Oncology
Richard Drexler, Mirco Kuchler, Kim C. Wagner, Tim Reese, Bernd Feyerabend, Moritz Kleine, Karl J. Oldhafer
Summary: The Hippo pathway is more active in non-metastasized patients compared to metastasized patients, with upregulation of certain components in the latter group. High pYAP expression is associated with favorable overall survival (OS) and disease-free survival (DFS).
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Deirdre Kruger, Nicola Lahoud, Yandiswa Y. Yako, John Dever, Martin Smith
Summary: This study aimed to evaluate the risk factors, symptoms, and potential prognostic biomarkers in PDAC, showing that platelet count, IL-15, and GM-CSF could be potential indicators of metastatic disease in PDAC patients. Some risk factors and symptoms did not differ across different stages of cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Valeriya S. Tikhonova, Grigory G. Karmazanovsky, Evvgeny Kondratyev, Ivan S. Gruzdev, Kseniya A. Mikhaylyuk, Mikhail Y. Sinelnikov, Amiran Sh Revishvili
Summary: This study developed a diagnostic radiomic model-based algorithm for predicting the grade of pancreatic ductal adenocarcinoma (PDAC). The results showed that radiomics features vary in PDAC of different grades and increase the accuracy of preoperative CT diagnosis.
EUROPEAN RADIOLOGY
(2023)
Editorial Material
Physiology
Hiromichi Sato, Tomoaki Hara, Shotaro Tatekawa, Kazuki Sasaki, Shogo Kobayashi, Toru Kitagawa, Yuichiro Doki, Hidetoshi Eguchi, Kazuhiko Ogawa, Shizuka Uchida, Hideshi Ishii
Summary: An international project on the human genome has shown that various types of RNA play a role in the development of human diseases, including cancer. Recent studies have focused on the important roles of long noncoding RNAs (lncRNAs) and circular RNA (circRNA) in pancreatic ductal adenocarcinoma (PDAC), particularly in the epithelial-mesenchymal transition, a process that regulates cancer metastasis. Research in this field has suggested that the tertiary structure of lncRNAs regulates their biological function through interactions with other RNAs or proteins, which can aid in early diagnosis and treatment selection for various diseases, including cancer. This article describes the emerging roles of ncRNAs in PDAC and highlights how they can be used to detect and control this difficult-to-treat cancer.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Oncology
Jingpiao Bao, Chaoliang Xu, Bin Li, Zengkai Wu, Jie Shen, Pengli Song, Qi Peng, Guoyong Hu
Summary: This study discovered that KPNA4 is significantly upregulated in PDAC and is associated with tumor progression and unfavorable prognosis. Knocking down KPNA4 suppressed the proliferation and migration of PDAC cells. Additionally, KPNA4 was also correlated with immune-suppressive cell infiltration and T cell exhaustion.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ahmad Alkhasawneh, Tasnuva Rashid, Ibraheem Mohammed, Basma Elhaddad, Hassan Al-Balas, Mayur Virarkar, Ziad Awad, Brett Baskovich, Arun Gopinath
Summary: This study evaluated the prognostic significance of duodenal wall invasion in pancreatic adenocarcinoma. It found that duodenal wall invasion is associated with lymph node metastasis but not with disease-free/overall survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Cell Biology
Helge Taubert, Markus Eckstein, Elena Epple, Rudolf Jung, Katrin Weigelt, Verena Lieb, Danijel Sikic, Robert Stoehr, Carol Geppert, Veronika Weyerer, Simone Bertz, Astrid Kehlen, Arndt Hartmann, Bernd Wullich, Sven Wach
Summary: Adjuvant chemotherapy is commonly used for muscle invasive bladder cancer patients, but existing biomarkers cannot predict which patients will benefit. Examining immune cell markers, this study found that the presence of tumor-infiltrating immune cells is associated with prognosis, and the impact of chemotherapy on prognosis depends on the expression of immune markers. Identifying specific immune markers, such as macrophages, may help predict chemotherapy response and patient outcomes after radical treatment for bladder cancer.
Article
Oncology
Veronika Weyerer, Pamela L. Strissel, Reiner Strick, Danijel Sikic, Carol I. Geppert, Simone Bertz, Fabienne Lange, Helge Taubert, Sven Wach, Johannes Breyer, Christian Bolenz, Philipp Erben, Bernd J. Schmitz-Draeger, Bernd Wullich, Arndt Hartmann, Markus Eckstein
Summary: This study highlights the limitations of current PD-L1 scoring algorithms in predicting immune therapy response in urothelial cancer patients. Comprehensive integration of PD-L1 expression and immune phenotypes is suggested for better patient stratification and prediction of treatment outcomes.
Article
Biology
Thomas Greither, Tina Steiner, Matthias Bache, Ginette Serrero, Sven Otto, Helge Taubert, Alexander W. Eckert, Matthias Kappler
Summary: The study suggests that increased levels of GP88 in the serum of oral squamous cell carcinoma (OSCC) patients are associated with a better prognosis, and may serve as an independent predictor of OSCC patients' outcomes. Low serum GP88 levels are significantly linked to a worsened prognosis for OSCC, especially in patients over the age of 60.5.
Article
Cell Biology
Markus Eckstein, Verena Lieb, Rudolf Jung, Danijel Sikic, Katrin Weigelt, Robert Stohr, Carol Geppert, Veronika Weyerer, Simone Bertz, Ginette Serrero, Binbin Yue, Arndt Hartmann, Bernd Wullich, Helge Taubert, Sven Wach
Summary: In urothelial bladder cancer, positive expression of GP88 in tumor cells is associated with poor prognosis, while negative expression of GP88 in immune cells is an independent negative predictor. The combination of GP88 staining in both tumor cells and immune cells is a significant independent prognostic biomarker in muscle-invasive BCa.
Article
Biology
Danijel Sikic, Helge Taubert, Ralph M. Wirtz, Johannes Breyer, Markus Eckstein, Veronika Weyerer, Jennifer Kubon, Philipp Erben, Christian Bolenz, Maximilian Burger, Arndt Hartmann, Bernd Wullich, Sven Wach, Bastian Keck
Summary: High AR mRNA expression is correlated with KRT5 mRNA expression and associated with an improved outcome in high-risk NMIBC, but these molecular markers do not have advantages as independent prognostic factors.
Article
Biochemistry & Molecular Biology
Maria Giebler, Thomas Greither, Diana Handke, Gregor Seliger, Hermann M. Behre
Summary: The study showed that lower levels of spermatozoal PIWI-LIKE 1 and 2 mRNA are positively associated with a higher fertilization rate in IVF cycles, but not in ICSI cycles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Verena Lieb, Amer Abdulrahman, Katrin Weigelt, Siegfried Hauch, Michael Gombert, Juan Guzman, Laura Bellut, Peter J. Goebell, Robert Stohr, Arndt Hartmann, Bernd Wullich, Helge Taubert, Sven Wach
Summary: Prostate cancer is a significant cause of morbidity and mortality among men globally, and there is a critical need for biomarkers for diagnosis, prognosis, and therapy prediction. Liquid biopsies like cfDNA and CTCs have shown promise in providing valuable information for prostate cancer patients. In this study, the analysis of cfDNA and CTCs revealed associations with overall survival, disease-specific survival, time to treatment change, and specific gene variants like BRCA1 and AR ligand-binding domain, highlighting their potential in guiding treatment decisions for advanced prostate cancer patients.
Article
Biology
Alexander Marquardt, Mario Richterstetter, Helge Taubert, Arndt Hartmann, Bernd Wullich, Verena Lieb, Laura Bellut, Sven Wach, Hendrik Apel
Summary: The use of photodynamic diagnostics (PDD) in bladder cancer treatment leads to improved tumor detection rates and reduced recurrence rates. It also reduces the incidence of residual tumors at the initial resection site in extended transurethral resection of the bladder tumor (TURBT) procedures.
Article
Biology
Alexander Fichte, Angela Neumann, Katrin Weigelt, Juan Guzman, Thilo Jansen, Julia Keinert, Ginette Serrero, Binbin Yue, Robert Stoehr, Thomas Greither, Arndt Hartmann, Bernd Wullich, Helge Taubert, Sven Wach, Verena Lieb
Summary: Our study aimed to evaluate the potential of using miR-486 and GP88 as biomarkers for diagnosing and predicting prostate cancer. The results showed that miR-486 and GP88 were not associated with cancer diagnosis, but significant differences were observed in elderly PCa patients. Additionally, adding miR-486 and GP88 to the baseline model improved the accuracy of predicting definitive therapy.
Article
Biochemistry & Molecular Biology
Thomas Greither, Hermann M. Behre, Holger Herlyn
Summary: Deciphering the functional relationships between genes associated with phenotypic variations can be challenging. In this study, a genome-wide association study (GWAS) linked twelve non-synonymous single-nucleotide polymorphisms (SNPs) to fertility variation in men. These SNPs were located in nine genes that have been previously implicated in male fertility. The study also identified potential biomarkers for the diagnosis of male fertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Verena Lieb, Amer Abdulrahman, Katrin Weigelt, Siegfried Hauch, Michael Gombert, Juan Guzman, Laura Bellut, Peter J. Goebell, Robert Stohr, Arndt Hartmann, Bernd Wullich, Helge Taubert, Sven Wach
Summary: In this study, the analysis of cell-free DNA from advanced prostate cancer patients revealed that gene variants in DNA damage repair genes can provide prognostic information, which may be useful for guiding future treatment decisions.
Article
Andrology
Thomas Greither, Mario Dejung, Hermann M. Behre, Falk Butter, Holger Herlyn
Summary: Through proteomic analysis of spermatozoa from 76 infertile men, we identified abnormal proteins related to sperm motility, fertilization capacity, and male reproductive development. These findings provide insights into the molecular mechanisms underlying male infertility.
Article
Medicine, General & Internal
Marios Marcou, Matthias Galiano, Anja Tzschoppe, Katja Sauerstein, Sven Wach, Helge Taubert, Bernd Wullich, Karin Hirsch-Koch, Hendrik Apel
Summary: Recognizing risk factors is crucial for decision-making in pediatric kidney transplantation. A retrospective study identified small body surface area (<1 m(2)) as a favorable prognostic factor for long-term graft survival, while adolescents over the age of 12 had poorer outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)