Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity

(2017) Pascal Krotee et al.   eLife

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

(2016) Mohd Waseem Akhtar et al.   Nature Communications

Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding

(2016) Rebecca Beveridge et al.   Nature Communications

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease

(2016) Dag Sehlin et al.   Nature Communications

Structural identification of electron transfer dissociation products in mass spectrometry using infrared ion spectroscopy

(2016) Jonathan Martens et al.   Nature Communications

Phosphorylation modifies the molecular stability of β-amyloid deposits

(2016) Nasrollah Rezaei-Ghaleh et al.   Nature Communications

The Prion-Like Properties of Amyloid-β Assemblies: Implications for Alzheimer's Disease

(2016) Lary C. Walker et al.   Cold Spring Harbor Perspectives in Medicine

Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

(2016) Andisheh Abedini et al.   eLife

The Effect of Glycosaminoglycans (GAGs) on Amyloid Aggregation and Toxicity

(2015) Clara Iannuzzi et al.   MOLECULES

Light Chain Amyloid Fibrils Cause Metabolic Dysfunction in Human Cardiomyocytes

(2015) Helen P. McWilliams-Koeppen et al.   PLoS One

pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers

(2015) Kevin W. Tipping et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantifying the stabilizing effects of protein–ligand interactions in the gas phase

(2015) Timothy M. Allison et al.   Nature Communications

Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

(2015) Matthias Altmeyer et al.   Nature Communications

Mechanistic Contributions of Biological Cofactors in Islet Amyloid Polypeptide Amyloidogenesis

(2015) Phuong Trang Nguyen et al.   Journal of Diabetes Research

Mutational Analysis of Preamyloid Intermediates: The Role of His-Tyr Interactions in Islet Amyloid Formation

(2014) Ling-Hsien Tu et al.   BIOPHYSICAL JOURNAL

β2-Microglobulin Amyloid Fibrils Are Nanoparticles That Disrupt Lysosomal Membrane Protein Trafficking and Inhibit Protein Degradation by Lysosomes

(2014) Toral Jakhria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into the Mechanism of Protein Electrospray Ionization From Salt Adduction Measurements

(2014) Xuanfeng Yue et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry

(2014) Lydia M. Young et al.   Nature Chemistry

Apoptosis induced by islet amyloid polypeptide soluble oligomers is neutralized by diabetes-associated specific antibodies

(2014) Yaron Bram et al.   Scientific Reports

Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity

(2013) Ping Cao et al.   FEBS LETTERS

Expanding the Repertoire of Amyloid Polymorphs by Co-polymerization of Related Protein Precursors

(2013) Claire J. Sarell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ion Mobility Spectrometry–Mass Spectrometry Defines the Oligomeric Intermediates in Amylin Amyloid Formation and the Mode of Action of Inhibitors

(2013) Lydia M. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel insights into protein misfolding diseases revealed by ion mobility-mass spectrometry

(2013) Danielle M. Williams et al.   MASS SPECTROMETRY REVIEWS

Assessing the causes and consequences of co-polymerization in amyloid formation

(2013) Claire J Sarell et al.   Prion

Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient  -sheet

(2013) L. E. Buchanan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Islet amyloid polypeptide toxicity and membrane interactions

(2013) P. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Familial Alzheimer’s Disease Mutations Differentially Alter Amyloid β-Protein Oligomerization

(2012) Megan Murray Gessel et al.   ACS Chemical Neuroscience

Amyloid fibril protein nomenclature: 2012 recommendations from the Nomenclature Committee of the International Society of Amyloidosis

(2012) Jean D. Sipe et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Ionic Strength Effects on Amyloid Formation by Amylin Are a Complicated Interplay among Debye Screening, Ion Selectivity, and Hofmeister Effects

(2012) Peter J. Marek et al.   BIOCHEMISTRY

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Hyperamylinemia Contributes to Cardiac Dysfunction in Obesity and Diabetes

(2012) Sanda Despa et al.   CIRCULATION RESEARCH

Aggregation of islet amyloid polypeptide: from physical chemistry to cell biology

(2012) Ping Cao et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

(2012) Justin M. Nussbaum et al.   NATURE

Two-dimensional infrared spectroscopy reveals the complex behaviour of an amyloid fibril inhibitor

(2012) Chris T. Middleton et al.   Nature Chemistry

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

(2012) C. E. Bulawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer

(2012) Lijuan Kang et al.   PROTEIN SCIENCE

Atomic View of a Toxic Amyloid Small Oligomer

(2012) Arthur Laganowsky et al.   SCIENCE

Membrane Disruption and Early Events in the Aggregation of the Diabetes Related Peptide IAPP from a Molecular Perspective

(2011) Jeffrey R. Brender et al.   ACCOUNTS OF CHEMICAL RESEARCH

Toxic effects of amyloid fibrils on cell membranes: the importance of ganglioside GM1

(2011) Monica Bucciantini et al.   FASEB JOURNAL

Structural Basis for Increased Toxicity of Pathological Aβ42:Aβ40Ratios in Alzheimer Disease

(2011) Kris Pauwels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prions and protein-folding diseases

(2011) E. Norrby   JOURNAL OF INTERNAL MEDICINE

Ion Mobility Separation Coupled with MS Detects Two Structural States of Alzheimer's Disease Aβ1–40 Peptide Oligomers

(2011) Marcin Kłoniecki et al.   JOURNAL OF MOLECULAR BIOLOGY

The Amyloid Formation Mechanism in Human IAPP: Dimers Have β-Strand Monomer−Monomer Interfaces

(2011) Nicholas F. Dupuis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conformational Conversion during Amyloid Formation at Atomic Resolution

(2011) Timo Eichner et al.   MOLECULAR CELL

Potent amyloidogenicity and pathogenicity of Aβ43

(2011) Takashi Saito et al.   NATURE NEUROSCIENCE

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Amyloid in the islets of Langerhans: Thoughts and some historical aspects

(2011) Per Westermark   UPSALA JOURNAL OF MEDICAL SCIENCES

Protein Solubility and Protein Homeostasis: A Generic View of Protein Misfolding Disorders

(2011) M. Vendruscolo et al.   Cold Spring Harbor Perspectives in Biology

Collision Cross Sections of Proteins and Their Complexes: A Calibration Framework and Database for Gas-Phase Structural Biology

(2010) Matthew F. Bush et al.   ANALYTICAL CHEMISTRY

Combination of Kinetically Selected Inhibitorsin TransLeads to Highly Effective Inhibition of Amyloid Formation

(2010) Fanling Meng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ion mobility–mass spectrometry reveals a conformational conversion from random assembly to β-sheet in amyloid fibril formation

(2010) Christian Bleiholder et al.   Nature Chemistry

Efficient Microwave-Assisted Synthesis of Human Islet Amyloid Polypeptide Designed to Facilitate the Specific Incorporation of Labeled Amino Acids

(2010) Peter Marek et al.   ORGANIC LETTERS

Prion propagation by Hsp40 molecular chaperones

(2010) Daniel W. Summers et al.   Prion

The Ability of Rodent Islet Amyloid Polypeptide To Inhibit Amyloid Formation by Human Islet Amyloid Polypeptide Has Important Implications for the Mechanism of Amyloid Formation and the Design of Inhibitors

(2009) Ping Cao et al.   BIOCHEMISTRY

Deciphering Drift Time Measurements from Travelling Wave Ion Mobility Spectrometry-Mass Spectrometry Studies

(2009) David P. Smith et al.   EUROPEAN JOURNAL OF MASS SPECTROMETRY

Glimpses of the molecular mechanisms of β2 -microglobulin fibril formation in vitro: Aggregation on a complex energy landscape

(2009) Geoffrey W. Platt et al.   FEBS LETTERS

Human Islet Amyloid Polypeptide Monomers Form Ordered β-hairpins: A Possible Direct Amyloidogenic Precursor

(2009) Nicholas F. Dupuis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process

(2009) Jed J. W. Wiltzius et al.   PROTEIN SCIENCE

Reviews: Current Concepts in Alzheimer's Disease: A Multidisciplinary Review

(2008) Ludovico Minati et al.   American Journal of Alzheimers Disease and Other Dementias

Exploiting Cross-Amyloid Interactions To Inhibit Protein Aggregation but not Function: Nanomolar Affinity Inhibition of Insulin Aggregation by an IAPP Mimic

(2008) Aleksandra Velkova et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sedimentation Studies on Human Amylin Fail to Detect Low-Molecular-Weight Oligomers

(2008) Sara M. Vaiana et al.   BIOPHYSICAL JOURNAL

Fibril Growth Kinetics Reveal a Region of β2-microglobulin Important for Nucleation and Elongation of Aggregation

(2008) Geoffrey W. Platt et al.   JOURNAL OF MOLECULAR BIOLOGY

Amyloid accomplices and enforcers

(2004) Andrei T. Alexandrescu   PROTEIN SCIENCE