Neuroimmunophysiology of the gut: advances and emerging concepts focusing on the epithelium

Neuromodulators for Functional Gastrointestinal Disorders (Disorders of Gut−Brain Interaction): A Rome Foundation Working Team Report

(2018) Douglas A. Drossman et al.   GASTROENTEROLOGY

Drugs for Treating Opioid-Induced Constipation: A Mixed Treatment Comparison Network Meta-analysis of Randomized Controlled Clinical Trials

(2018) Kannan Sridharan et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Role of priority effects in the early-life assembly of the gut microbiota

(2018) Daniel Sprockett et al.   Nature Reviews Gastroenterology & Hepatology

Ghrelin: A Link Between Energy Homeostasis and the Immune System

(2017) Julie A. Chowen et al.   ENDOCRINOLOGY

Optogenetic Analysis of Depolarization-Dependent Glucagonlike Peptide-1 Release

(2017) Catalin Chimerel et al.   ENDOCRINOLOGY

Prucalopride for the treatment of ileus

(2017) Christopher J Smart et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Redox signaling in the gastrointestinal tract

(2017) Salvador Pérez et al.   FREE RADICAL BIOLOGY AND MEDICINE

Complementary and Alternative Medicines Used by Patients With Inflammatory Bowel Diseases

(2017) Adam S. Cheifetz et al.   GASTROENTEROLOGY

Enteric Glia Regulate Gastrointestinal Motility but Are Not Required for Maintenance of the Epithelium in Mice

(2017) Meenakshi Rao et al.   GASTROENTEROLOGY

The Vagus Nerve in Appetite Regulation, Mood, and Intestinal Inflammation

(2017) Kirsteen N. Browning et al.   GASTROENTEROLOGY

Giardia duodenalis induces pathogenic dysbiosis of human intestinal microbiota biofilms

(2017) Jennifer K. Beatty et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Mucosal pathobiology and molecular signature of epithelial barrier dysfunction in the small intestine in irritable bowel syndrome

(2017) Ana M González-Castro et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Vagus nerve stimulation: a new promising therapeutic tool in inflammatory bowel disease

(2017) B. Bonaz et al.   JOURNAL OF INTERNAL MEDICINE

Increased incidence of psychiatric disorders in immune-mediated inflammatory disease

(2017) Ruth Ann Marrie et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

Ghrelin protects the heart against ischemia/reperfusion injury via inhibition of TLR4/NLRP3 inflammasome pathway

(2017) Qin Wang et al.   LIFE SCIENCES

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

(2017) Christoph S. N. Klose et al.   NATURE

Neuronal regulation of type 2 innate lymphoid cells via neuromedin U

(2017) Vânia Cardoso et al.   NATURE

Interplay between metabolic identities in the intestinal crypt supports stem cell function

(2017) Maria J. Rodríguez-Colman et al.   NATURE

Interactions between the microbiota, immune and nervous systems in health and disease

(2017) Thomas C Fung et al.   NATURE NEUROSCIENCE

The mucosal immune system: master regulator of bidirectional gut–brain communications

(2017) Nick Powell et al.   Nature Reviews Gastroenterology & Hepatology

Non-conventional features of peripheral serotonin signalling — the gut and beyond

(2017) Stephanie N. Spohn et al.   Nature Reviews Gastroenterology & Hepatology

GLP-1 and the kidney: from physiology to pharmacology and outcomes in diabetes

(2017) Marcel H. A. Muskiet et al.   Nature Reviews Nephrology

Stress and brain functional changes in patients with Crohn's disease: A functional magnetic resonance imaging study

(2017) A. Agostini et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Modulation of brainstem activity and connectivity by respiratory-gated auricular vagal afferent nerve stimulation in migraine patients

(2017) Ronald G. Garcia et al.   PAIN

A randomized trial of relamorelin for constipation in Parkinson's disease (MOVE-PD): Trial results and lessons learned

(2017)   PARKINSONISM & RELATED DISORDERS

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

(2017) Lidia Bosurgi et al.   SCIENCE

Brain changes detected by functional magnetic resonance imaging and spectroscopy in patients with Crohn's disease

(2017) Kun Lv et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Species dependent impact of helminth-derived antigens on human macrophages infected with Mycobacterium tuberculosis: Direct effect on the innate anti-mycobacterial response

(2017) Naomi Aira et al.   PLoS Neglected Tropical Diseases

Future Treatment of Constipation-associated Disorders: Role of Relamorelin and Other Ghrelin Receptor Agonists

(2017) Paula Mosińska et al.   Journal of Neurogastroenterology and Motility

Patterns of Early-Life Gut Microbial Colonization during Human Immune Development: An Ecological Perspective

(2017) Isabelle Laforest-Lapointe et al.   Frontiers in Immunology

Functional dyspepsia

(2017) Paul Enck et al.   Nature Reviews Disease Primers

Management of functional dyspepsia: state of the art and emerging therapies

(2017) Hiroshi Yamawaki et al.   Therapeutic Advances in Chronic Disease

Longitudinal sampling of the lung microbiota in individuals with cystic fibrosis

(2017) Fiona J. Whelan et al.   PLoS One

Randomised clinical trial: prucalopride, a colonic pro-motility agent, reduces the duration of post-operative ileus after elective gastrointestinal surgery

(2016) J. Gong et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Type 3 muscarinic receptors contribute to intestinal mucosal homeostasis and clearance of Nippostrongylus brasiliensis through induction of TH2 cytokines

(2016) Leon P. McLean et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Prucalopride exerts neuroprotection in human enteric neurons

(2016) Francesca Bianco et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Butyrate enhances antibacterial effects while suppressing other features of alternative activation in IL-4-induced macrophages

(2016) Maria R. Fernando et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Transcutaneous Vagus Nerve Stimulation (tVNS) for Treatment of Drug-Resistant Epilepsy: A Randomized, Double-Blind Clinical Trial (cMPsE02)

(2016) S. Bauer et al.   Brain Stimulation

Bidirectional crosstalk via IL-6, PGE2 and PGD2 between murine myofibroblasts and alternatively activated macrophages enhances anti-inflammatory phenotype in both cells

(2016) Maria R Fernando et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ghrelin and the Cardiovascular System

(2016) Brian M. Lilleness et al.   Cardiology in Review

Neuro-Immune Interactions at Barrier Surfaces

(2016) Henrique Veiga-Fernandes et al.   CELL

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome

(2016) Aleksey Chudnovskiy et al.   CELL

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome

(2016) Meital Gury-BenAri et al.   CELL

Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations

(2016) Christoph A. Thaiss et al.   CELL

Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages

(2016) Ilana Gabanyi et al.   CELL

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

The entangled ER-mitochondrial axis as a potential therapeutic strategy in neurodegeneration: A tangled duo unchained

(2016) Amit U. Joshi et al.   CELL CALCIUM

Intrinsic Defense Mechanisms of the Intestinal Epithelium

(2016) Deepshika Ramanan et al.   Cell Host & Microbe

TLR ligands and butyrate increasePyyexpression through two distinct but inter-regulated pathways

(2016) Pierre Larraufie et al.   CELLULAR MICROBIOLOGY

Effect of Yoga in the Therapy of Irritable Bowel Syndrome: A Systematic Review

(2016) Dania Schumann et al.   Clinical Gastroenterology and Hepatology

Regulation and plasticity of intestinal stem cells during homeostasis and regeneration

(2016) Joep Beumer et al.   DEVELOPMENT

Ghrelin ameliorates atherosclerosis by inhibiting endoplasmic reticulum stress

(2016) Wenting Ai et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Inflammation and the Intestinal Barrier: Leukocyte–Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair

(2016) Anny-Claude Luissint et al.   GASTROENTEROLOGY

Relamorelin Reduces Vomiting Frequency and Severity and Accelerates Gastric Emptying in Adults With Diabetic Gastroparesis

(2016) Anthony Lembo et al.   GASTROENTEROLOGY

Protective Actions of Epithelial 5-Hydroxytryptamine 4 Receptors in Normal and Inflamed Colon

(2016) Stephanie N. Spohn et al.   GASTROENTEROLOGY

Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation

(2016) Pawan Kumar et al.   IMMUNITY

Neuro-immune interactions in the cholinergic anti-inflammatory reflex

(2016) Colin Reardon   IMMUNOLOGY LETTERS

Helminth Regulation of Immunity

(2016) Fernando Lopes et al.   INFLAMMATORY BOWEL DISEASES

Molecular Signaling and Dysfunction of the Human Reactive Enteric Glial Cell Phenotype

(2016) Andromeda Liñán-Rico et al.   INFLAMMATORY BOWEL DISEASES

Growing up in a Bubble: Using Germ-Free Animals to Assess the Influence of the Gut Microbiota on Brain and Behavior

(2016) Pauline Luczynski et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes

(2016) Tsuyoshi Inoue et al.   JOURNAL OF CLINICAL INVESTIGATION

The common mouse protozoa Tritrichomonas muris alters mucosal T cell homeostasis and colitis susceptibility

(2016) Nichole K. Escalante et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice

(2016) Angélica T. Vieira et al.   JOURNAL OF LEUKOCYTE BIOLOGY

TLR2 and TLR9 modulate enteric nervous system inflammatory responses to lipopolysaccharide

(2016) Joan F. Burgueño et al.   Journal of Neuroinflammation

Neural FFA3 activation inversely regulates anion secretion evoked by nicotinic ACh receptor activation in rat proximal colon

(2016) Izumi Kaji et al.   JOURNAL OF PHYSIOLOGY-LONDON

Heart Rate Recovery Is Impaired in Patients with Inflammatory Bowel Diseases

(2016) Bahadir Sarli et al.   MEDICAL PRINCIPLES AND PRACTICE

Intestinal tuft cells: epithelial sentinels linking luminal cues to the immune system

(2016) F Gerbe et al.   Mucosal Immunology

Persistent microbiome alterations modulate the rate of post-dieting weight regain

(2016) Christoph A. Thaiss et al.   NATURE

Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence

(2016) Sales Ibiza et al.   NATURE

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

(2016) François Gerbe et al.   NATURE

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

Diet–microbiota interactions as moderators of human metabolism

(2016) Justin L. Sonnenburg et al.   NATURE

Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis

(2016) Christoph S N Klose et al.   NATURE IMMUNOLOGY

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

(2016) Michael J Workman et al.   NATURE MEDICINE

The bowel and beyond: the enteric nervous system in neurological disorders

(2016) Meenakshi Rao et al.   Nature Reviews Gastroenterology & Hepatology

Human mini-guts: new insights into intestinal physiology and host–pathogen interactions

(2016) Julie G. In et al.   Nature Reviews Gastroenterology & Hepatology

The intestinal epithelial barrier: a therapeutic target?

(2016) Matthew A. Odenwald et al.   Nature Reviews Gastroenterology & Hepatology

Emerging pathogenic links between microbiota and the gut–lung axis

(2016) Kurtis F. Budden et al.   NATURE REVIEWS MICROBIOLOGY

Vagal tone: effects on sensitivity, motility, and inflammation

(2016) B. Bonaz et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Chronic vagus nerve stimulation in Crohn's disease: a 6-month follow-up pilot study

(2016) B. Bonaz et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Can exercise affect the course of inflammatory bowel disease? Experimental and clinical evidence

(2016) Jan Bilski et al.   Pharmacological Reports

The maternal microbiota drives early postnatal innate immune development

(2016) M. Gomez de Aguero et al.   SCIENCE

Helminth infection promotes colonization resistance via type 2 immunity

(2016) Deepshika Ramanan et al.   SCIENCE

How colonization by microbiota in early life shapes the immune system

(2016) Thomas Gensollen et al.   SCIENCE

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

(2016) H. Chu et al.   SCIENCE

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

(2016) G. M. H. Birchenough et al.   SCIENCE

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

(2016) M. R. Howitt et al.   SCIENCE

What a Dinner Party! Mechanisms and Functions of Interkingdom Signaling in Host-Pathogen Associations

(2016) Melissa M. Kendall et al.   mBio

Bacteriome and Mycobiome Interactions Underscore Microbial Dysbiosis in Familial Crohn’s Disease

(2016) G. Hoarau et al.   mBio

Alterations of the human gut microbiome in multiple sclerosis

(2016) Sushrut Jangi et al.   Nature Communications

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways

(2016) Jian Tan et al.   Cell Reports

IL-22 Restrains Tapeworm-Mediated Protection against Experimental Colitis via Regulation of IL-25 Expression

(2016) José L. Reyes et al.   PLoS Pathogens

The intestinal immunoendocrine axis: novel cross-talk between enteroendocrine cells and the immune system during infection and inflammatory disease: Figure 1

(2015) John J Worthington   BIOCHEMICAL SOCIETY TRANSACTIONS

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

(2015) Koji Atarashi et al.   CELL

Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function

(2015) Caleb J. Kelly et al.   Cell Host & Microbe

Relamorelin Relieves Constipation and Accelerates Colonic Transit in a Phase 2, Placebo-Controlled, Randomized Trial

(2015) Andres Acosta et al.   Clinical Gastroenterology and Hepatology

Stress and the Microbiota-Gut-Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome

(2015) Rachel D. Moloney et al.   CNS Neuroscience & Therapeutics

Review of the Uses of Vagal Nerve Stimulation in Chronic Pain Management

(2015) Krishnan Chakravarthy et al.   Current Pain and Headache Reports

Short-Term Effects of Relamorelin on Descending Colon Motility in Chronic Constipation: A Randomized, Controlled Trial

(2015) Andres Acosta et al.   DIGESTIVE DISEASES AND SCIENCES

Surgically implanted and non-invasive vagus nerve stimulation: a review of efficacy, safety and tolerability

(2015) E. Ben-Menachem et al.   EUROPEAN JOURNAL OF NEUROLOGY

The treatment of gastroparesis, constipation and small intestinal bacterial overgrowth syndrome in patients with Parkinson’s disease

(2015) Jose L Barboza et al.   EXPERT OPINION ON PHARMACOTHERAPY

Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

(2015) Christopher S. Reigstad et al.   FASEB JOURNAL

Gut commensal microvesicles reproduce parent bacterial signals to host immune and enteric nervous systems

(2015) Khalid Al-Nedawi et al.   FASEB JOURNAL

Inhibiting Inducible Nitric Oxide Synthase in Enteric Glia Restores Electrogenic Ion Transport in Mice With Colitis

(2015) Sarah J. MacEachern et al.   GASTROENTEROLOGY

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

(2015) Mario M. Zaiss et al.   IMMUNITY

Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage

(2015) Denise N. Bronner et al.   IMMUNITY

Barrier Epithelial Cells and the Control of Type 2 Immunity

(2015) Hamida Hammad et al.   IMMUNITY

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

Adherent-Invasive Escherichia coli Production of Cellulose Influences Iron-Induced Bacterial Aggregation, Phagocytosis, and Induction of Colitis

(2015) Melissa Ellermann et al.   INFECTION AND IMMUNITY

Campylobacter jejuni Increases Flagellar Expression and Adhesion of Noninvasive Escherichia coli: Effects on Enterocytic Toll-Like Receptor 4 and CXCL-8 Expression

(2015) Kristen L. Reti et al.   INFECTION AND IMMUNITY

The Effect of Breathing, Movement, and Meditation on Psychological and Physical Symptoms and Inflammatory Biomarkers in Inflammatory Bowel Disease

(2015) Patricia L. Gerbarg et al.   INFLAMMATORY BOWEL DISEASES

Gut chemosensing mechanisms

(2015) Arianna Psichas et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging roles for enteric glia in gastrointestinal disorders

(2015) Keith A. Sharkey   JOURNAL OF CLINICAL INVESTIGATION

Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells

(2015) Diego V. Bohórquez et al.   JOURNAL OF CLINICAL INVESTIGATION

Soluble Dextrin Fibers Alter the Intestinal Microbiota and Reduce Proinflammatory Cytokine Secretion in Male IL-10–Deficient Mice

(2015) Rosica Valcheva et al.   JOURNAL OF NUTRITION

Vagus Nerve Mediates the Neural Stem Cell Response to Intestinal Injury

(2015) Simone Langness et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Regulation of Mitochondrial Dynamics by Dynamin-Related Protein-1 in Acute Cardiorenal Syndrome

(2015) M. Sumida et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Toll like receptor-2 regulates production of glial-derived neurotrophic factors in murine intestinal smooth muscle cells

(2015) Paola Brun et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Unknown

(2015) Gabriella Leung et al.   MOLECULAR MEDICINE

Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit

(2015) Jakob von Moltke et al.   NATURE

Ghrelin and motilin receptors as drug targets for gastrointestinal disorders

(2015) Gareth J. Sanger et al.   Nature Reviews Gastroenterology & Hepatology

The gut microbiome restores intrinsic and extrinsic nerve function in germ-free mice accompanied by changes in calbindin

(2015) K. A. McVey Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria

(2015) Panagiotis S. Kabouridis et al.   NEURON

Self-regulation evaluation of therapeutic yoga and walking for patients with irritable bowel syndrome: a pilot study

(2015) Leila Shahabi et al.   Psychology Health & Medicine

Early infancy microbial and metabolic alterations affect risk of childhood asthma

(2015) Marie-Claire Arrieta et al.   Science Translational Medicine

Microbiota and host determinants of behavioural phenotype in maternally separated mice

(2015) G. De Palma et al.   Nature Communications

ILC2s and T cells cooperate to ensure maintenance of M2 macrophages for lung immunity against hookworms

(2015) Tiffany Bouchery et al.   Nature Communications

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Balance of Autonomic Nervous System Predicts Who Benefits from a Self-management Intervention Program for Irritable Bowel Syndrome

(2015) Monica E Jarrett et al.   Journal of Neurogastroenterology and Motility

Optical Tools to Investigate Cellular Activity in the Intestinal Wall

(2015) Werend Boesmans et al.   Journal of Neurogastroenterology and Motility

Microbiota–mitochondria inter-talk: consequence for microbiota–host interaction

(2015) Yann Saint-Georges-Chaumet et al.   Pathogens and Disease

Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity

(2015) D. Val-Laillet et al.   NeuroImage-Clinical

Targeting Mitochondria-Derived Reactive Oxygen Species to Reduce Epithelial Barrier Dysfunction and Colitis

(2014) Arthur Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Effect of transcutaneous auricular vagus nerve stimulation on impaired glucose tolerance: a pilot randomized study

(2014) Feng Huang et al.   BMC Complementary and Alternative Medicine

Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis

(2014) Christoph A. Thaiss et al.   CELL

Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility

(2014) Paul Andrew Muller et al.   CELL

Vibrio cholerae T3SS Effector VopE Modulates Mitochondrial Dynamics and Innate Immune Signaling by Targeting Miro GTPases

(2014) Masato Suzuki et al.   Cell Host & Microbe

Abnormal mitochondrial fusion–fission balance contributes to the progression of experimental sepsis

(2014) A. S. Gonzalez et al.   FREE RADICAL RESEARCH

Segmented Filamentous Bacterium Uses Secondary and Tertiary Lymphoid Tissues to Induce Gut IgA and Specific T Helper 17 Cell Responses

(2014) Emelyne Lécuyer et al.   IMMUNITY

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

(2014) Dror S. Shouval et al.   IMMUNITY

Serotonin 5-HT7 Receptor Is Critically Involved in Acute and Chronic Inflammation of the Gastrointestinal Tract

(2014) Daria Guseva et al.   INFLAMMATORY BOWEL DISEASES

Transcutaneous electrical stimulation of auricular branch of vagus nerve: A noninvasive therapeutic approach for post-ischemic heart failure

(2014) Zhuo Wang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

A Gut Microbial Metabolite of Linoleic Acid, 10-Hydroxy-cis-12-octadecenoic Acid, Ameliorates Intestinal Epithelial Barrier Impairment Partially via GPR40-MEK-ERK Pathway

(2014) Junki Miyamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-lived intestinal tuft cells serve as colon cancer–initiating cells

(2014) C. Benedikt Westphalen et al.   JOURNAL OF CLINICAL INVESTIGATION

Mindfulness-based therapy for inflammatory bowel disease patients with functional abdominal symptoms or high perceived stress levels

(2014) James W. Berrill et al.   Journal of Crohns & Colitis

Gut Microbes and the Brain: Paradigm Shift in Neuroscience

(2014) E. A. Mayer et al.   JOURNAL OF NEUROSCIENCE

Preclinical gastrointestinal prokinetic efficacy and endocrine effects of the ghrelin mimetic RM-131

(2014) Lex Van der Ploeg et al.   LIFE SCIENCES

Standardised animal models of host microbial mutualism

(2014) A J Macpherson et al.   Mucosal Immunology

Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon

(2014) K A Knoop et al.   Mucosal Immunology

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

(2014) Jan Mauer et al.   NATURE IMMUNOLOGY

Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion

(2014) Fei Chen et al.   NATURE IMMUNOLOGY

Prucalopride decreases esophageal acid exposure and accelerates gastric emptying in healthy subjects

(2014) B. F. Kessing et al.   NEUROGASTROENTEROLOGY AND MOTILITY

An Enteroendocrine Cell – Enteric Glia Connection Revealed by 3D Electron Microscopy

(2014) Diego V. Bohórquez et al.   PLoS One

Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis

(2014) A. Mortha et al.   SCIENCE

Helminth infection reactivates latent  -herpesvirus via cytokine competition at a viral promoter

(2014) T. A. Reese et al.   SCIENCE

Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation

(2014) L. C. Osborne et al.   SCIENCE

Cholinergic Signaling in the Gut: A Novel Mechanism of Barrier Protection through Activation of Enteric Glia Cells

(2014) Gerald A. Cheadle et al.   Surgical Infections

Systematic review with meta-analysis: highly selective 5-HT4 agonists (prucalopride, velusetrag or naronapride) in chronic constipation

(2013) A. Shin et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation

(2013) Bo Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Paneth Cells: Maestros of the Small Intestinal Crypts

(2013) Hans C. Clevers et al.   Annual Review of Physiology

Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract

(2013) Keith A. Sharkey et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences

(2013) F. O. Martinez et al.   BLOOD

Microbial Modulation of Energy Availability in the Colon Regulates Intestinal Transit

(2013) Anita Wichmann et al.   Cell Host & Microbe

Inflammation-Induced Alteration of Astrocyte Mitochondrial Dynamics Requires Autophagy for Mitochondrial Network Maintenance

(2013) Elisa Motori et al.   Cell Metabolism

GPR41/FFAR3 and GPR43/FFAR2 as Cosensors for Short-Chain Fatty Acids in Enteroendocrine Cells vs FFAR3 in Enteric Neurons and FFAR2 in Enteric Leukocytes

(2013) Mark K. Nøhr et al.   ENDOCRINOLOGY

The Unfolded Protein Response and Chemical Chaperones Reduce Protein Misfolding and Colitis in Mice

(2013) Stewart Siyan Cao et al.   GASTROENTEROLOGY

Toll-Like Receptor 2 Regulates Intestinal Inflammation by Controlling Integrity of the Enteric Nervous System

(2013) Paola Brun et al.   GASTROENTEROLOGY

Complex Interactions Among Diet, Gastrointestinal Transit, and Gut Microbiota in Humanized Mice

(2013) Purna C. Kashyap et al.   GASTROENTEROLOGY

Enteroglial-derived S100B protein integrates bacteria-induced Toll-like receptor signalling in human enteric glial cells

(2013) Fabio Turco et al.   GUT

A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen

(2013) Gianluca Matteoli et al.   GUT

Palmitoylethanolamide improves colon inflammation through an enteric glia/toll like receptor 4-dependent PPAR-α activation

(2013) Giuseppe Esposito et al.   GUT

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Group 3 Innate Lymphoid Cells Inhibit T-Cell-Mediated Intestinal Inflammation through Aryl Hydrocarbon Receptor Signaling and Regulation of Microflora

(2013) Ju Qiu et al.   IMMUNITY

Inhibition of mitochondrial fragmentation diminishes Huntington’s disease–associated neurodegeneration

(2013) Xing Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells

(2013) Steven A. Saenz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeted Inhibition of Serotonin Type 7 (5-HT7) Receptor Function Modulates Immune Responses and Reduces the Severity of Intestinal Inflammation

(2013) J. J. Kim et al.   JOURNAL OF IMMUNOLOGY

The Parkinson's disease-associated genePINK1protects neurons from ischemic damage by decreasing mitochondrial translocation of the fission promoter Drp1

(2013) Yanxin Zhao et al.   JOURNAL OF NEUROCHEMISTRY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Dietary intervention impact on gut microbial gene richness

(2013) Aurélie Cotillard et al.   NATURE

Type 2 innate lymphoid cells control eosinophil homeostasis

(2013) Jesse C. Nussbaum et al.   NATURE

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets

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