A Gut Microbial Metabolite of Linoleic Acid, 10-Hydroxy-cis-12-octadecenoic Acid, Ameliorates Intestinal Epithelial Barrier Impairment Partially via GPR40-MEK-ERK Pathway
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Title
A Gut Microbial Metabolite of Linoleic Acid, 10-Hydroxy-cis-12-octadecenoic Acid, Ameliorates Intestinal Epithelial Barrier Impairment Partially via GPR40-MEK-ERK Pathway
Authors
Keywords
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Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 290, Issue 5, Pages 2902-2918
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2014-12-12
DOI
10.1074/jbc.m114.610733
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Note: Only part of the references are listed.- GPR40 activation leads to CREB and ERK phosphorylation in primary cultures of neurons from the mouse CNS and in human neuroblastoma cells
- (2014) Marta Zamarbide et al. HIPPOCAMPUS
- Adalimumab prevents barrier dysfunction and antagonizes distinct effects of TNF-α on tight junction proteins and signaling pathways in intestinal epithelial cells
- (2013) Andreas Fischer et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
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- (2013) C. F. Burant DIABETES CARE
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- (2013) Zongxian Cao et al. GASTROENTEROLOGY
- TNFR2 Activates MLCK-Dependent Tight Junction Dysregulation to Cause Apoptosis-Mediated Barrier Loss and Experimental Colitis
- (2013) Liping Su et al. GASTROENTEROLOGY
- Functional bowel symptoms in quiescent inflammatory bowel diseases: role of epithelial barrier disruption and low-grade inflammation
- (2013) M Vivinus-Nébot et al. GUT
- The Effect of Probiotics and Gut Microbiota on Th17 Cells
- (2013) Soichi Tanabe INTERNATIONAL REVIEWS OF IMMUNOLOGY
- The Free Fatty Acid Receptor G Protein-coupled Receptor 40 (GPR40) Protects from Bone Loss through Inhibition of Osteoclast Differentiation
- (2013) Fabien Wauquier et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protective role of tumor necrosis factor (TNF) receptors in chronic intestinal inflammation: TNFR1 ablation boosts systemic inflammatory response
- (2013) Yi Wang et al. LABORATORY INVESTIGATION
- PepT1 expressed in immune cells has an important role in promoting the immune response during experimentally induced colitis
- (2013) Saravanan Ayyadurai et al. LABORATORY INVESTIGATION
- IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism
- (2013) A Eken et al. Mucosal Immunology
- Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
- (2013) Yukihiro Furusawa et al. NATURE
- Molecular signatures of G-protein-coupled receptors
- (2013) A. J. Venkatakrishnan et al. NATURE
- Bifidobacterium longum Alleviates Dextran Sulfate Sodium-Induced Colitis by Suppressing IL-17A Response: Involvement of Intestinal Epithelial Costimulatory Molecules
- (2013) Eiji Miyauchi et al. PLoS One
- Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy
- (2013) J. V. Gerasimenko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition
- (2013) S. Kishino et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis
- (2013) P. M. Smith et al. SCIENCE
- The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43
- (2013) Ikuo Kimura et al. Nature Communications
- Acetyl salicylic acid induces damage to intestinal epithelial cells by oxidation-related modifications of ZO-1
- (2012) Akifumi Fukui et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation
- (2012) Daisuke Inoue et al. FEBS LETTERS
- Requirement of Cellular Prion Protein for Intestinal Barrier Function and Mislocalization in Patients With Inflammatory Bowel Disease
- (2012) Constance S.V. Petit et al. GASTROENTEROLOGY
- Cytokines induce tight junction disassembly in airway cells via an EGFR-dependent MAPK/ERK1/2-pathway
- (2012) Loredana Petecchia et al. LABORATORY INVESTIGATION
- RORγt-dependent IL-17A-producing cells in the pathogenesis of intestinal inflammation
- (2012) T Kanai et al. Mucosal Immunology
- Rapid induction of inflammatory lipid mediators by the inflammasome in vivo
- (2012) Jakob von Moltke et al. NATURE
- Increased Oral Detection, but Decreased Intestinal Signaling for Fats in Mice Lacking Gut Microbiota
- (2012) Frank A. Duca et al. PLoS One
- Opposite Role of Tumor Necrosis Factor Receptors in Dextran Sulfate Sodium-Induced Colitis in Mice
- (2012) Ke Wang et al. PLoS One
- Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier
- (2011) Rana Al-Sadi et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- A GPR40 Agonist GW9508 Suppresses CCL5, CCL17, and CXCL10 Induction in Keratinocytes and Attenuates Cutaneous Immune Inflammation
- (2011) Tomoko Fujita et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Conjugated linoleic acid protects against gliadin-induced depletion of intestinal defenses
- (2011) Paolo Bergamo et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Genetics and pathogenesis of inflammatory bowel disease
- (2011) Bernard Khor et al. NATURE
- Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats
- (2010) Kazuma Hamada et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects
- (2010) Da Young Oh et al. CELL
- PPARγ-dependent peptidoglycan recognition protein 3 (PGlyRP3) expression regulates proinflammatory cytokines by microbial and dietary fatty acids
- (2010) Marwa Zenhom et al. IMMUNOBIOLOGY
- Importance of disrupted intestinal barrier in inflammatory bowel diseases
- (2010) Saʼad Y. Salim et al. INFLAMMATORY BOWEL DISEASES
- TNFα-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFκB signaling
- (2010) Maren Amasheh et al. JOURNAL OF CELL SCIENCE
- Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis
- (2009) Rudolf Mennigen et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Epithelial Tight Junctions in Intestinal Inflammation
- (2009) Joerg D. Schulzke et al. Annals of the New York Academy of Sciences
- Conjugated linoleic acid prevents cell growth and cytokine production induced by TPA in human keratinocytes NCTC 2544
- (2009) Germana Martinasso et al. CANCER LETTERS
- G Protein-Coupled Receptor 43 Is Essential for Neutrophil Recruitment during Intestinal Inflammation
- (2009) C. Sina et al. JOURNAL OF IMMUNOLOGY
- G-protein-coupled receptor 40 (GPR40) expression and its regulation in human pancreatic islets: The role of type 2 diabetes and fatty acids
- (2009) S. Del Guerra et al. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
- Proinflammatory cytokines tumor necrosis factor-α and interferon-γ alter tight junction structure and function in the rat parotid gland Par-C10 cell line
- (2008) Olga J. Baker et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
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- (2008) T Piche et al. GUT
- Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation
- (2008) Christopher R Weber et al. LABORATORY INVESTIGATION
- Molecular mechanism of intestinal permeability: interaction at tight junctions
- (2008) Zakir Hossain et al. Molecular BioSystems
- Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41
- (2008) B. S. Samuel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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