Ghrelin and motilin receptors as drug targets for gastrointestinal disorders
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Ghrelin and motilin receptors as drug targets for gastrointestinal disorders
Authors
Keywords
-
Journal
Nature Reviews Gastroenterology & Hepatology
Volume 13, Issue 1, Pages 38-48
Publisher
Springer Nature
Online
2015-09-22
DOI
10.1038/nrgastro.2015.163
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- 1483O_PRANAMORELIN FOR THE TREATMENT OF CANCER ANOREXIA-CACHEXIA IN NSCLC: RESULTS FROM THE PHASE 3 STUDIES ROMANA 1 AND 2
- (2017) J. Temel et al. ANNALS OF ONCOLOGY
- Analysis of the ghrelin receptor-independent vascular actions of ulimorelin
- (2015) John Broad et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Visually induced nausea causes characteristic changes in cerebral, autonomic and endocrine function in humans
- (2015) Adam D. Farmer et al. JOURNAL OF PHYSIOLOGY-LONDON
- A ghrelin receptor agonist is an effective colokinetic in rats with diet-induced constipation
- (2015) R. V. Pustovit et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Mo2081 Effect of RQ-00201894, a Small Non-Peptide Motilin Agonist, on Laparotomy and Clonidine Induced Gastrointestinal Hypomotility in Dogs
- (2015) Nobuyuki Takahashi et al. GASTROENTEROLOGY
- Sa2046 Effect of RM-131 on Circular Smooth Muscle Cells in Human and Mouse Colon and on Colonic Intraluminal Pressure in Conscious Mice
- (2014) Lei Sha et al. GASTROENTEROLOGY
- 70 A Randomized, Double-Blind, Placebo-Controlled Phase II Study (MOT114479) to Evaluate the Safety and Efficacy and Dose Response of 28 Days of Orally Administered Camicinal, a Motilin Receptor Agonist, in Diabetics With Gastroparesis
- (2014) Matthew E. Barton et al. GASTROENTEROLOGY
- Sa2051 A Phase II, Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose, Parallel-Group Study to Evaluate the Efficacy, Safety, and Pharmacodynamics of RM-131 in Patients With Chronic Constipation
- (2014) Andres Acosta et al. GASTROENTEROLOGY
- Small Molecule Ghrelin Receptor Inverse Agonists and Antagonists
- (2014) Kimberly O. Cameron et al. JOURNAL OF MEDICINAL CHEMISTRY
- Regionally dependent neuromuscular functions of motilin and 5-HT4receptors in human isolated esophageal body and gastric fundus
- (2014) J. Broad et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Ghrelin and motilin receptor agonists: time to introduce bias into drug design
- (2014) G. J. Sanger NEUROGASTROENTEROLOGY AND MOTILITY
- Emerging treatments in Neurogastroenterology: relamorelin: a novel gastrocolokinetic synthetic ghrelin agonist
- (2014) M. Camilleri et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Endogenous motilin, but not ghrelin plasma levels fluctuate in accordance with gastric phase III activity of the migrating motor complex in man
- (2014) E. Deloose et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Drugs acting at 5-HT4, D2, motilin, and ghrelin receptors differ markedly in how they affect neuromuscular functions in human isolated stomach
- (2014) J. Broad et al. NEUROGASTROENTEROLOGY AND MOTILITY
- New ghrelin agonist, HM01 alleviates constipation and L-dopa-delayed gastric emptying in 6-hydroxydopamine rat model of Parkinson's disease
- (2014) H. Karasawa et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Characterization of ghrelin-sensitive neurons in the lumbosacral defecation center in rats
- (2014) K. Naitou et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Unacylated Ghrelin Suppresses Ghrelin-Induced Neuronal Activity in the Hypothalamus and Brainstem of Male Rats
- (2014) Darko M. Stevanovic et al. PLoS One
- Pharmacokinetics of the ghrelin agonist capromorelin in a single ascending dose Phase-I safety trial in spinal cord-injured and able-bodied volunteers
- (2014) A G Ellis et al. SPINAL CORD
- Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate
- (2014) Samit K. Bhattacharya et al. ACS Medicinal Chemistry Letters
- Gastric dysrhythmias: a potential objective measure of nausea
- (2014) Kenneth L. Koch EXPERIMENTAL BRAIN RESEARCH
- Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor
- (2013) Kim F. McClure et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Functionally biased signalling properties of 7TM receptors - opportunities for drug development for the ghrelin receptor
- (2013) B Sivertsen et al. BRITISH JOURNAL OF PHARMACOLOGY
- The Ghrelin Agonist RM-131 Accelerates Gastric Emptying of Solids and Reduces Symptoms in Patients With Type 1 Diabetes Mellitus
- (2013) Andrea Shin et al. Clinical Gastroenterology and Hepatology
- Safety and Efficacy of Ulimorelin Administered Postoperatively to Accelerate Recovery of Gastrointestinal Motility Following Partial Bowel Resection
- (2013) Monica Shaw et al. DISEASES OF THE COLON & RECTUM
- The relationship between gastric motility and nausea: Gastric prokinetic agents as treatments
- (2013) Gareth J. Sanger et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Nausea and the quest for the perfect anti-emetic
- (2013) Paul L.R. Andrews et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Role of Ghrelin in the Pathophysiology of Gastrointestinal Disease
- (2013) Cynthia K. Cheung et al. Gut and Liver
- Phase 2b, randomized, double-blind 12-week studies of TZP-102, a ghrelin receptor agonist for diabetic gastroparesis
- (2013) R. W. McCallum et al. NEUROGASTROENTEROLOGY AND MOTILITY
- The mechanism of enhanced defecation caused by the ghrelin receptor agonist, ulimorelin
- (2013) R. V. Pustovit et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Ghrelin signaling in the gut, its physiological properties, and therapeutic potential
- (2013) B. Avau et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons
- (2013) Marie Schaeffer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Decreasing Colectomy Rates for Ulcerative Colitis: A Population-Based Time Trend Study
- (2012) Gilaad G Kaplan et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Regional- and agonist-dependent facilitation of human neurogastrointestinal functions by motilin receptor agonists
- (2012) J Broad et al. BRITISH JOURNAL OF PHARMACOLOGY
- Motilin: towards a new understanding of the gastrointestinal neuropharmacology and therapeutic use of motilin receptor agonists
- (2012) G J Sanger et al. BRITISH JOURNAL OF PHARMACOLOGY
- The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin
- (2012) John Broad et al. BRITISH JOURNAL OF PHARMACOLOGY
- Identification of neurons that express ghrelin receptors in autonomic pathways originating from the spinal cord
- (2012) John B. Furness et al. CELL AND TISSUE RESEARCH
- Clinical Application of Ghrelin
- (2012) Florian Strasser CURRENT PHARMACEUTICAL DESIGN
- MECHANISMS IN ENDOCRINOLOGY: Ghrelin: the differences between acyl- and des-acyl ghrelin
- (2012) Patric J D Delhanty et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Anti-emetic and emetic effects of erythromycin in Suncus murinus: Role of vagal nerve activation, gastric motility stimulation and motilin receptors
- (2012) Farideh A. Javid et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Apo-Ghrelin Receptor Forms Heteromers with DRD2 in Hypothalamic Neurons and Is Essential for Anorexigenic Effects of DRD2 Agonism
- (2012) Andras Kern et al. NEURON
- Molecular identification of GHS-R and GPR38 in Suncus murinus
- (2012) Airi Suzuki et al. PEPTIDES
- A relationship between motilin and growth hormone secretagogue receptors
- (2012) Hiroaki Nunoi et al. REGULATORY PEPTIDES
- Interdigestive migrating contractions are coregulated by ghrelin and motilin in conscious dogs
- (2011) Atsushi Ogawa et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Obestatin: An Interesting but Controversial Gut Hormone
- (2011) Antonio Lacquaniti et al. ANNALS OF NUTRITION AND METABOLISM
- Structure, regulation and function of ghrelin
- (2011) T. Sato et al. JOURNAL OF BIOCHEMISTRY
- The truncated ghrelin receptor polypeptide (GHS-R1b) is localized in the endoplasmic reticulum where it forms heterodimers with ghrelin receptors (GHS-R1a) to attenuate their cell surface expression
- (2011) Kevin B.S. Chow et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Bitter taster status predicts susceptibility to vection-induced motion sickness and nausea
- (2011) P. W. Benson et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Bitter taste receptors and α-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying
- (2011) Sara Janssen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Long-term culture and cryopreservation of interstitial cells of Cajal
- (2011) Wen-Da Xu et al. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- Stimulation of defecation in spinal cord-injured rats by a centrally acting ghrelin receptor agonist
- (2011) D M Ferens et al. SPINAL CORD
- The translational value of rodent gastrointestinal functions: a cautionary tale
- (2011) Gareth J. Sanger et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Safety and efficacy of ghrelin agonist TZP-101 in relieving symptoms in patients with diabetic gastroparesis: a randomized, placebo-controlled study
- (2010) N. Ejskjaer et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Contrasting effects of ghrelin and des-acyl ghrelin on the lumbo-sacral defecation center and regulation of colorectal motility in rats
- (2010) H. Hirayama et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Functional and in situ hybridization evidence that preganglionic sympathetic vasoconstrictor neurons express ghrelin receptors
- (2010) D.M. Ferens et al. NEUROSCIENCE
- Association between plasma ghrelin and motilin levels during MMC cycle in conscious dogs
- (2010) Aaron Zietlow et al. REGULATORY PEPTIDES
- Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists
- (2009) Alexander Pasternak et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Mechanism of interdigestive migrating motor complex in conscious dogs
- (2009) Hitoshi Nakajima et al. JOURNAL OF GASTROENTEROLOGY
- Enhanced Gastrointestinal Motility with Orally Active Ghrelin Receptor Agonists
- (2009) S. Charoenthongtrakul et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Actions and therapeutic pathways of ghrelin for gastrointestinal disorders
- (2009) Michael Camilleri et al. Nature Reviews Gastroenterology & Hepatology
- GSK962040: a small molecule, selective motilin receptor agonist, effective as a stimulant of human and rabbit gastrointestinal motility
- (2009) g. j. sanger et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Fixed feeding potentiates interdigestive gastric motor activity in rats: importance of eating habits for maintaining interdigestive MMC
- (2008) Hajime Ariga et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Erythromycin lacks colon prokinetic effect in children with functional gastrointestinal disorders: a retrospective study
- (2008) Narayanan Venkatasubramani et al. BMC GASTROENTEROLOGY
- Motilin, ghrelin and related neuropeptides as targets for the treatment of GI diseases
- (2008) Gareth J. Sanger DRUG DISCOVERY TODAY
- Effect of the ghrelin receptor agonist TZP-101 on colonic transit in a rat model of postoperative ileus
- (2008) Graeme L. Fraser et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Motilin receptor expression in smooth muscle, myenteric plexus, and mucosa of human inflamed and noninflamed intestine
- (2008) Pascale W. Ter Beek et al. INFLAMMATORY BOWEL DISEASES
- Development of drugs for gastrointestinal motor disorders: translating science to clinical need
- (2008) g. j. sanger et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Oral administration of a centrally acting ghrelin receptor agonist to conscious rats triggers defecation
- (2008) a. d. shafton et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Differences between the abilities of tegaserod and motilin receptor agonists to stimulate gastric motility in vitro
- (2007) E M Jarvie et al. BRITISH JOURNAL OF PHARMACOLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now