A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575)

Implications of Plasma Protein Binding for Pharmacokinetics and Pharmacodynamics of the  -Secretase Inhibitor RO4929097

(2012) J. Wu et al.   CLINICAL CANCER RESEARCH

A phase II study of RO4929097 in metastatic colorectal cancer

(2012) Jonathan R. Strosberg et al.   EUROPEAN JOURNAL OF CANCER

Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors

(2012) Ian Krop et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors

(2012) Anthony W. Tolcher et al.   JOURNAL OF CLINICAL ONCOLOGY

Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma

(2012) Natalie Cook et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High tumor levels of IL6 and IL8 abrogate preclinical efficacy of the γ-secretase inhibitor, RO4929097

(2011) Wei He et al.   Molecular Oncology

Preclinical Profile of a Potent  -Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties

(2009) L. Luistro et al.   CANCER RESEARCH

Angiogenesis: A Team Effort Coordinated by Notch

(2009) L.-K. Phng et al.   DEVELOPMENTAL CELL

Inhibition of γ-Secretase Activity Inhibits Tumor Progression in a Mouse Model of Pancreatic Ductal Adenocarcinoma

(2009) Ruben Plentz et al.   GASTROENTEROLOGY

Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way

(2009) Peter Carmeliet et al.   Nature Reviews Clinical Oncology

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

(2008) E.A. Eisenhauer et al.   EUROPEAN JOURNAL OF CANCER

Determination of intact oxaliplatin in human plasma using high performance liquid chromatography-tandem mass spectrometry

(2008) Wenjiang Zhang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Rational targeting of Notch signaling in cancer

(2008) P Rizzo et al.   ONCOGENE

Notch signaling regulates tumor angiogenesis by diverse mechanisms

(2008) J Dufraine et al.   ONCOGENE