标题
Tackling the cancer stem cells — what challenges do they pose?
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 13, Issue 7, Pages 497-512
出版商
Springer Nature
发表日期
2014-07-01
DOI
10.1038/nrd4253
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Molecular identification and targeting of colorectal cancer stem cells
- (2015) Oncotarget
- Evolution of the Cancer Stem Cell Model
- (2014) Antonija Kreso et al. Cell Stem Cell
- Clinical evaluation of tocilizumab for patients with active rheumatoid arthritis refractory to anti-TNF biologics: tocilizumab in combination with methotrexate
- (2014) Yasuharu Nakashima et al. Modern Rheumatology
- Protein Kinase C α Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells
- (2013) Wai Leong Tam et al. CANCER CELL
- Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer
- (2013) Chenfang Dong et al. CANCER CELL
- JAK-STAT Blockade Inhibits Tumor Initiation and Clonogenic Recovery of Prostate Cancer Stem-like Cells
- (2013) P. Kroon et al. CANCER RESEARCH
- Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors
- (2013) A. Jimeno et al. CLINICAL CANCER RESEARCH
- Targeting TGF-β signaling in cancer
- (2013) Lior H Katz et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575)
- (2013) Suzanne Richter et al. INVESTIGATIONAL NEW DRUGS
- TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer
- (2013) Neil E. Bhola et al. JOURNAL OF CLINICAL INVESTIGATION
- Cancer stem cells: The challenges ahead
- (2013) Jan Paul Medema NATURE CELL BIOLOGY
- The epigenetics of epithelial-mesenchymal plasticity in cancer
- (2013) Wai Leong Tam et al. NATURE MEDICINE
- Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
- (2013) J. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
- (2013) M. Yu et al. SCIENCE
- A prostaglandin E (PGE) receptor EP4 antagonist protects natural killer cells from PGE2-mediated immunosuppression and inhibits breast cancer metastasis
- (2013) Xinrong Ma et al. OncoImmunology
- Epithelial-to-Mesenchymal Transition Leads to Docetaxel Resistance in Prostate Cancer and Is Mediated by Reduced Expression of miR-200c and miR-205
- (2012) Martin Puhr et al. AMERICAN JOURNAL OF PATHOLOGY
- Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
- (2012) Douglas Hanahan et al. CANCER CELL
- Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1
- (2012) Oscar H. Ocaña et al. CANCER CELL
- Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis
- (2012) Jeff H. Tsai et al. CANCER CELL
- Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells
- (2012) Eleftherios Sachlos et al. CELL
- Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State
- (2012) Wenjun Guo et al. CELL
- β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis
- (2012) Joseph Rosenbluh et al. CELL
- EMT and Dissemination Precede Pancreatic Tumor Formation
- (2012) Andrew D. Rhim et al. CELL
- Genetic and Pharmacologic Inhibition of β-Catenin Targets Imatinib-Resistant Leukemia Stem Cells in CML
- (2012) Florian H. Heidel et al. Cell Stem Cell
- The extracellular matrix: A dynamic niche in cancer progression
- (2012) Pengfei Lu et al. JOURNAL OF CELL BIOLOGY
- Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells
- (2012) Toni Celià-Terrassa et al. JOURNAL OF CLINICAL INVESTIGATION
- Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors
- (2012) Ian Krop et al. JOURNAL OF CLINICAL ONCOLOGY
- Small Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 (Stat3) Protein
- (2012) Bikash Debnath et al. JOURNAL OF MEDICINAL CHEMISTRY
- MEDI0639: A Novel Therapeutic Antibody Targeting Dll4 Modulates Endothelial Cell Function and Angiogenesis In Vivo
- (2012) D. W. Jenkins et al. MOLECULAR CANCER THERAPEUTICS
- Defining the mode of tumour growth by clonal analysis
- (2012) Gregory Driessens et al. NATURE
- RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis
- (2012) Min Yu et al. NATURE
- EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
- (2012) Michael T. McCabe et al. NATURE
- A restricted cell population propagates glioblastoma growth after chemotherapy
- (2012) Jian Chen et al. NATURE
- Epithelial Mesenchymal Transition and Pancreatic Tumor Initiating CD44+/EpCAM+ Cells Are Inhibited by γ-Secretase Inhibitor IX
- (2012) Vindhya Palagani et al. PLoS One
- Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy
- (2012) S. M. McAuliffe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas
- (2012) A. G. Schepers et al. SCIENCE
- Phosphosulindac (OXT-328) Selectively Targets Breast Cancer Stem Cells In Vitro and in Human Breast Cancer Xenografts
- (2012) Caihua Zhu et al. STEM CELLS
- Mevalonate Metabolism Regulates Basal Breast Cancer Stem Cells and Is a Potential Therapeutic Target
- (2012) Christophe Ginestier et al. STEM CELLS
- Tumor-Associated Macrophages Regulate Murine Breast Cancer Stem Cells Through a Novel Paracrine EGFR/Stat3/Sox-2 Signaling Pathway
- (2012) Jian Yang et al. STEM CELLS
- Emodin As an Effective Agent in Targeting Cancer Stem-Like Side Population Cells of Gallbladder Carcinoma
- (2012) Xin-xing Li et al. STEM CELLS AND DEVELOPMENT
- Cancer-Stimulated Mesenchymal Stem Cells Create a Carcinoma Stem Cell Niche via Prostaglandin E 2 Signaling
- (2012) Hua-Jung Li et al. Cancer Discovery
- Identification of inhibitors of ovarian cancer stem-like cells by high-throughput screening
- (2012) Roman Mezencev et al. Journal of Ovarian Research
- The Ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease
- (2011) M. Angela Nieto Annual Review of Cell and Developmental Biology
- Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
- (2011) Scott R. Daigle et al. CANCER CELL
- MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L
- (2011) Kathrin M. Bernt et al. CANCER CELL
- Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth
- (2011) Michael Quante et al. CANCER CELL
- Endothelial Cells Create a Stem Cell Niche in Glioblastoma by Providing NOTCH Ligands That Nurture Self-Renewal of Cancer Stem-Like Cells
- (2011) T. S. Zhu et al. CANCER RESEARCH
- Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks
- (2011) Suling Liu et al. CANCER RESEARCH
- STAT3 Is Necessary for Proliferation and Survival in Colon Cancer-Initiating Cells
- (2011) L. Lin et al. CANCER RESEARCH
- Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion
- (2011) B. Dirat et al. CANCER RESEARCH
- Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells
- (2011) Piyush B. Gupta et al. CELL
- Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast
- (2011) Christina Scheel et al. CELL
- Pharmacokinetics of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Locally Advanced or Metastatic Solid Tumors: the Role of Alpha-1-Acid Glycoprotein Binding
- (2011) R. A. Graham et al. CLINICAL CANCER RESEARCH
- Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors
- (2011) P. M. LoRusso et al. CLINICAL CANCER RESEARCH
- Identification of CD44+CD24+ gastric cancer stem cells
- (2011) Chaojun Zhang et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors
- (2011) Lauren L.C. Marotta et al. JOURNAL OF CLINICAL INVESTIGATION
- A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis
- (2011) Howard Trachtman et al. KIDNEY INTERNATIONAL
- CD90 is Identified as a Candidate Marker for Cancer Stem Cells in Primary High-Grade Gliomas Using Tissue Microarrays
- (2011) Jintang He et al. MOLECULAR & CELLULAR PROTEOMICS
- A Molecular Screening Approach to Identify and Characterize Inhibitors of Glioblastoma Stem Cells
- (2011) K. Visnyei et al. MOLECULAR CANCER THERAPEUTICS
- Tumour evolution inferred by single-cell sequencing
- (2011) Nicholas Navin et al. NATURE
- Interactions between cancer stem cells and their niche govern metastatic colonization
- (2011) Ilaria Malanchi et al. NATURE
- Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells
- (2011) M. Jinushi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway
- (2011) F. C. Gonsalves et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
- (2011) C. L. Chaffer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy
- (2011) David G. DeNardo et al. Cancer Discovery
- An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation
- (2010) K. P. A. MacDonald et al. BLOOD
- The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
- (2010) Patrick S. Ward et al. CANCER CELL
- β-Catenin Mediates the Establishment and Drug Resistance of MLL Leukemic Stem Cells
- (2010) Jenny Yeung et al. CANCER CELL
- TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma
- (2010) Judit Anido et al. CANCER CELL
- Regulation of Breast Cancer Stem Cell Activity by Signaling through the Notch4 Receptor
- (2010) H. Harrison et al. CANCER RESEARCH
- A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth
- (2010) Alexander Roesch et al. CELL
- Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content
- (2010) Salvatore Pece et al. CELL
- Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
- (2010) Stefan Gross et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Selection of Tumorigenic Melanoma Cells Using ALDH
- (2010) Jim B. Boonyaratanakornkit et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Prognostic Significance of Tumorigenic Cells With Mesenchymal Features in Pancreatic Adenocarcinoma
- (2010) Zeshaan A. Rasheed et al. JNCI-Journal of the National Cancer Institute
- Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
- (2010) Louis Vermeulen et al. NATURE CELL BIOLOGY
- Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
- (2010) F. Stephen Hodi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Distinct Expression Levels and Patterns of Stem Cell Marker, Aldehyde Dehydrogenase Isoform 1 (ALDH1), in Human Epithelial Cancers
- (2010) Shan Deng et al. PLoS One
- Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma
- (2010) S. Buonamici et al. Science Translational Medicine
- Epithelial-Mesenchymal Transition-Derived Cells Exhibit Multilineage Differentiation Potential Similar to Mesenchymal Stem Cells
- (2010) Venkata Lokesh Battula et al. STEM CELLS
- Quiescent, Slow-Cycling Stem Cell Populations in Cancer: A Review of the Evidence and Discussion of Significance
- (2010) Nathan Moore et al. Journal of Oncology
- Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer
- (2009) Yu-Chih Chen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- GDC-0449—A potent inhibitor of the hedgehog pathway
- (2009) Kirk D. Robarge et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Slow proliferation as a biological feature of colorectal cancer metastasis
- (2009) A Anjomshoaa et al. BRITISH JOURNAL OF CANCER
- The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors
- (2009) Michael Hedvat et al. CANCER CELL
- CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages
- (2009) David G. DeNardo et al. CANCER CELL
- Aldehyde Dehydrogenase-Expressing Colon Stem Cells Contribute to Tumorigenesis in the Transition from Colitis to Cancer
- (2009) J. E. Carpentino et al. CANCER RESEARCH
- Aldehyde Dehydrogenase 1 Is a Marker for Normal and Malignant Human Colonic Stem Cells (SC) and Tracks SC Overpopulation during Colon Tumorigenesis
- (2009) E. H. Huang et al. CANCER RESEARCH
- Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening
- (2009) Piyush B. Gupta et al. CELL
- Epithelial-Mesenchymal Transitions in Development and Disease
- (2009) Jean Paul Thiery et al. CELL
- DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency
- (2009) Timothy Hoey et al. Cell Stem Cell
- PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells
- (2009) Anne-Marie Bleau et al. Cell Stem Cell
- Cells with Characteristics of Cancer Stem/Progenitor Cells Express the CD133 Antigen in Human Endometrial Tumors
- (2009) S. Rutella et al. CLINICAL CANCER RESEARCH
- Side population of pancreatic cancer cells predominates in TGF-β-mediated epithelial to mesenchymal transition and invasion
- (2009) Ayano Kabashima et al. INTERNATIONAL JOURNAL OF CANCER
- Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)
- (2009) Martin R. Tremblay et al. JOURNAL OF MEDICINAL CHEMISTRY
- Drugging the Wnt Pathway: Problems And Progress
- (2009) K. Garber JNCI-Journal of the National Cancer Institute
- Aldehyde Dehydrogenase 1 Is a Tumor Stem Cell-Associated Marker in Lung Cancer
- (2009) F. Jiang et al. MOLECULAR CANCER RESEARCH
- Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
- (2009) Shih-Min A. Huang et al. NATURE
- Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
- (2009) Baozhi Chen et al. Nature Chemical Biology
- A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer
- (2009) Pierre Farmer et al. NATURE MEDICINE
- Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
- (2009) Elaine R. Mardis et al. NEW ENGLAND JOURNAL OF MEDICINE
- IDH1andIDH2Mutations in Gliomas
- (2009) Hai Yan et al. NEW ENGLAND JOURNAL OF MEDICINE
- The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling
- (2009) L Lin et al. ONCOGENE
- Chemoattractant Signaling between Tumor Cells and Macrophages Regulates Cancer Cell Migration, Metastasis and Neovascularization
- (2009) Chad E. Green et al. PLoS One
- Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment
- (2009) G. Bertolini et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells
- (2009) Nawneet K. Kurrey et al. STEM CELLS
- STAT3 Is Required for Proliferation and Maintenance of Multipotency in Glioblastoma Stem Cells
- (2009) Maureen M. Sherry et al. STEM CELLS
- Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44
- (2009) Shigeo Takaishi et al. STEM CELLS
- Transforming growth factor-β signaling: emerging stem cell target in metastatic breast cancer?
- (2008) Antoinette R. Tan et al. BREAST CANCER RESEARCH AND TREATMENT
- Expansion of Bcr-Abl-Positive Leukemic Stem Cells Is Dependent on Hedgehog Pathway Activation
- (2008) Christine Dierks et al. CANCER CELL
- Significance of CD90+ Cancer Stem Cells in Human Liver Cancer
- (2008) Zhen Fan Yang et al. CANCER CELL
- Cancer related inflammation: The macrophage connection
- (2008) Antonio Sica et al. CANCER LETTERS
- Redox mechanisms switch on hypoxia-dependent epithelial–mesenchymal transition in cancer cells
- (2008) Stefania Cannito et al. CARCINOGENESIS
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
- (2008) Sendurai A. Mani et al. CELL
- Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment
- (2008) Toula Bouras et al. Cell Stem Cell
- Recent Progress in the Medicinal Chemistry of γ-Secretase Inhibitors
- (2008) Richard Olson et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily
- (2008) Satori A Marchitti et al. Expert Opinion on Drug Metabolism & Toxicology
- Identification of local and circulating cancer stem cells in human liver cancer
- (2008) Zhen Fan Yang et al. HEPATOLOGY
- Characterization of a side population of astrocytoma cells in response to temozolomide
- (2008) Constance Chua et al. JOURNAL OF NEUROSURGERY
- Aldehyde Dehydrogenase Discriminates the CD133 Liver Cancer Stem Cell Populations
- (2008) S. Ma et al. MOLECULAR CANCER RESEARCH
- Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling
- (2008) Ilaria Malanchi et al. NATURE
- The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
- (2008) Heather R. Christofk et al. NATURE
- Efficient tumour formation by single human melanoma cells
- (2008) Elsa Quintana et al. NATURE
- Repression of E-cadherin by the polycomb group protein EZH2 in cancer
- (2008) Q Cao et al. ONCOGENE
- Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
- (2008) Anne-Pierre Morel et al. PLoS One
- Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity
- (2008) L. Vermeulen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An Integrated Genomic Analysis of Human Glioblastoma Multiforme
- (2008) D. W. Parsons et al. SCIENCE
- Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-β kinase antagonist, in mice
- (2007) Lorea Bueno et al. EUROPEAN JOURNAL OF CANCER
- Expression of CD133-1 and CD133-2 in ovarian cancer
- (2007) G. FERRANDINA et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Isolation and Molecular Characterization of Cancer Stem Cells in MMTV-Wnt-1Murine Breast Tumors
- (2007) Robert W. Cho et al. STEM CELLS
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