Energy landscapes of functional proteins are inherently risky

Local Transient Unfolding of Native State PAI-1 Associated with Serpin Metastability

(2014) Morten B. Trelle et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The robustness and innovability of protein folds

(2014) Ágnes Tóth-Petróczy et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Association of polyalanine and polyglutamine coiled coils mediates expansion disease-related protein aggregation and dysfunction

(2014) Ilaria Pelassa et al.   HUMAN MOLECULAR GENETICS

Secondary Structure in the Core of Amyloid Fibrils Formed from Human β2m and its Truncated Variant ΔN6

(2014) Yongchao Su et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visualization of Transient Protein-Protein Interactions that Promote or Inhibit Amyloid Assembly

(2014) Theodoros K. Karamanos et al.   MOLECULAR CELL

The ensemble nature of allostery

(2014) Hesam N. Motlagh et al.   NATURE

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The lectin OS-9 delivers mutant neuroserpin to endoplasmic reticulum associated degradation in familial encephalopathy with neuroserpin inclusion bodies

(2014) Angela Schipanski et al.   NEUROBIOLOGY OF AGING

Temperature-responsive release of thyroxine and its environmental adaptation in Australians

(2014) X. Qi et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

Delicate Balance between Functionally Required Flexibility and Aggregation Risk in a β-Rich Protein

(2013) Mylene C. Ferrolino et al.   BIOCHEMISTRY

Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic β2-Microglobulin

(2013) Levon Halabelian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure, Folding Dynamics, and Amyloidogenesis of D76N β2-Microglobulin

(2013) P. Patrizia Mangione et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein-Protein Interactions as a Strategy towards Protein-Specific Drug Design: The Example of Ataxin-1

(2013) Cesira de Chiara et al.   PLoS One

Chaperone activation by unfolding

(2013) L. Foit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frustration in the energy landscapes of multidomain protein misfolding

(2013) W. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early Folding Events Protect Aggregation-Prone Regions of a β-Rich Protein

(2013) Ivan L. Budyak et al.   STRUCTURE

Protein function and allostery: a dynamic relationship

(2012) Charalampos G. Kalodimos   Annals of the New York Academy of Sciences

Solution Structure and Backbone Dynamics of Human Liver Fatty Acid Binding Protein: Fatty Acid Binding Revisited

(2012) Jun Cai et al.   BIOPHYSICAL JOURNAL

Take home lessons from studies of related proteins

(2012) Adrian A Nickson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Endosomal Protein-Sorting Receptor Sortilin Has a Role in Trafficking  -1 Antitrypsin

(2012) C. L. Gelling et al.   GENETICS

How the Serpin α1-Proteinase Inhibitor Folds

(2012) Klavs Dolmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell biology of spinocerebellar ataxia

(2012) Harry T. Orr   JOURNAL OF CELL BIOLOGY

Hereditary Systemic Amyloidosis Due to Asp76Asn Variant β2-Microglobulin

(2012) Sophie Valleix et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Josephin Domain Determines the Morphological and Mechanical Properties of Ataxin-3 Fibrils

(2011) Laura Masino et al.   BIOPHYSICAL JOURNAL

The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure

(2011) Sara Raimondi et al.   BMC EVOLUTIONARY BIOLOGY

N-terminal ataxin-3 causes neurological symptoms with inclusions, endoplasmic reticulum stress and ribosomal dislocation

(2011) Jeannette Hübener et al.   BRAIN

The two faces of Janus: functional interactions and protein aggregation

(2011) Annalisa Pastore et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer

(2011) Masayuki Yamasaki et al.   EMBO REPORTS

Understanding the complex mechanisms of β2-microglobulin amyloid assembly

(2011) Timo Eichner et al.   FEBS Journal

Structural Instability Tuning as a Regulatory Mechanism in Protein-Protein Interactions

(2011) Li Chen et al.   MOLECULAR CELL

Conformational Conversion during Amyloid Formation at Atomic Resolution

(2011) Timo Eichner et al.   MOLECULAR CELL

Polyglutamine diseases: The special case of ataxin-3 and Machado–Joseph disease

(2011) Carlos A. Matos et al.   PROGRESS IN NEUROBIOLOGY

Dynamic Allostery: Linkers Are Not Merely Flexible

(2011) Buyong Ma et al.   STRUCTURE

An Evolutionary Trade-Off between Protein Turnover Rate and Protein Aggregation Favors a Higher Aggregation Propensity in Fast Degrading Proteins

(2011) Greet De Baets et al.   PLoS Computational Biology

Alpha-1-Antitrypsin Deficiency: Importance of Proteasomal and Autophagic Degradative Pathways in Disposal of Liver Disease–Associated Protein Aggregates

(2010) David H. Perlmutter   Annual Review of Medicine

Essential Role of Coiled Coils for Aggregation and Activity of Q/N-Rich Prions and PolyQ Proteins

(2010) Ferdinando Fiumara et al.   CELL

Intrinsic disorder in proteins associated with neurodegenerative diseases

(2010) Vladimir et al.   Frontiers in Bioscience-Landmark

A redox switch in angiotensinogen modulates angiotensin release

(2010) Aiwu Zhou et al.   NATURE

Understanding the Role of the Josephin Domain in the PolyUb Binding and Cleavage Properties of Ataxin-3

(2010) Giuseppe Nicastro et al.   PLoS One

Intrinsic tryptophans of CRABPI as probes of structure and folding

(2010) Patricia L. Clark et al.   PROTEIN SCIENCE

Conformational Pathology of the Serpins: Themes, Variations, and Therapeutic Strategies

(2009) Bibek Gooptu et al.   Annual Review of Biochemistry

Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation

(2009) Stefano Ricagno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Josephin domain of ataxin-3 contains two distinct ubiquitin-binding sites

(2009) Giuseppe Nicastro et al.   BIOPOLYMERS

Linking folding and binding

(2009) Peter E Wright et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Globular Tetramers of β2-Microglobulin Assemble into Elaborate Amyloid Fibrils

(2009) Helen E. White et al.   JOURNAL OF MOLECULAR BIOLOGY

A Generic Mechanism of β2-Microglobulin Amyloid Assembly at Neutral pH Involving a Specific Proline Switch

(2009) Timo Eichner et al.   JOURNAL OF MOLECULAR BIOLOGY

Functional Unfolding of α1-Antitrypsin Probed by Hydrogen-Deuterium Exchange Coupled with Mass Spectrometry

(2009) Je-Hyun Baek et al.   MOLECULAR & CELLULAR PROTEOMICS

The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB

(2008) E. Miranda et al.   HUMAN MOLECULAR GENETICS

Pathogenic Mechanisms of a Polyglutamine-mediated Neurodegenerative Disease, Spinocerebellar Ataxia Type 1

(2008) Huda Y. Zoghbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and functional analysis of fatty acid-binding proteins

(2008) Judith Storch et al.   JOURNAL OF LIPID RESEARCH

A Structural Basis for Loop C-Sheet Polymerization in Serpins

(2008) Qingwei Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

The Controlling Roles of Trp60 and Trp95 in β2-Microglobulin Function, Folding and Amyloid Aggregation Properties

(2008) Gennaro Esposito et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization

(2008) Masayuki Yamasaki et al.   NATURE

Conformational and dynamics changes induced by bile acids binding to chicken liver bile acid binding protein

(2008) Ivano Eberini et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS