Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer

A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with α1-antitrypsin deficiency

(2010) Elena Miranda et al.   HEPATOLOGY

Loop-Sheet Mechanism of Serpin Polymerization Tested by Reactive Center Loop Mutations

(2010) Masayuki Yamasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the mechanism of polymerization in the serpinopathies

(2010) U. I. Ekeowa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational Pathology of the Serpins: Themes, Variations, and Therapeutic Strategies

(2009) Bibek Gooptu et al.   Annual Review of Biochemistry

Expression, purification and characterization of recombinant Z α1-Antitrypsin—The most common cause of α1-Antitrypsin deficiency

(2009) Vita Levina et al.   PROTEIN EXPRESSION AND PURIFICATION

The molecular aetiology of the serpinopathies

(2008) M DAVIES et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Serpin polymerization and its role in disease-The molecular basis of α1-antitrypsin deficiency

(2008) Anja S. Knaupp et al.   IUBMB LIFE

Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization

(2008) Masayuki Yamasaki et al.   NATURE

Dimers Initiate and Propagate Serine Protease Inhibitor Polymerisation

(2007) Aiwu Zhou et al.   JOURNAL OF MOLECULAR BIOLOGY