General strategy for the generation of human antibody variable domains with increased aggregation resistance

Engineering Aggregation Resistance in IgG by Two Independent Mechanisms: Lessons from Comparison of Pichia pastoris and Mammalian Cell Expression

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Mutational analysis of domain antibodies reveals aggregation hotspots within and near the complementarity determining regions

(2011) Joseph M. Perchiacca et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Potential aggregation prone regions in biotherapeutics

(2010) Xiaoling Wang et al.   mAbs

Development trends for human monoclonal antibody therapeutics

(2010) Aaron L. Nelson et al.   NATURE REVIEWS DRUG DISCOVERY

Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site

(2009) J. Bostrom et al.   SCIENCE

Sequence determinants of protein aggregation in human VH domains

(2008) K. Dudgeon et al.   PROTEIN ENGINEERING DESIGN & SELECTION