Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development

Contrasting Responses of Lymphoid Progenitors to Canonical and Noncanonical Wnt Signals

(2014) S. Malhotra et al.   JOURNAL OF IMMUNOLOGY

Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells

(2011) C. Schaniel et al.   BLOOD

Differential niche and Wnt requirements during acute myeloid leukemia progression

(2011) S. W. Lane et al.   BLOOD

Canonical Wnt Signaling Regulates Hematopoiesis in a Dosage-Dependent Fashion

(2011) Tiago C. Luis et al.   Cell Stem Cell

Network of WNT and Other Regulatory Signaling Cascades in Pluripotent Stem Cells and Cancer Stem Cells

(2011) Masaru Katoh   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Self-renewal related signaling in myeloid leukemia stem cells

(2011) Florian H. Heidel et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Cutting Edge:  -Catenin Is Dispensable for T Cell Effector Differentiation, Memory Formation, and Recall Responses

(2011) M. Prlic et al.   JOURNAL OF IMMUNOLOGY

Tuning Wnt-signaling to enhance cardiomyogenesis in human embryonic and induced pluripotent stem cells

(2011) James E. Hudson et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis

(2011) B G Mar et al.   LEUKEMIA

Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications

(2011) F J T Staal et al.   LEUKEMIA

Notch signaling in mammalian hematopoietic stem cells

(2011) K V Pajcini et al.   LEUKEMIA

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS

(2010) S. W. Lane et al.   BLOOD

Wnt3a nonredundantly controls hematopoietic stem cell function and its deficiency results in complete absence of canonical Wnt signaling

(2010) T. C. Luis et al.   BLOOD

Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells

(2010) Nick Barker et al.   GASTROENTEROLOGY

Acute Myeloid Leukemia and the Wnt Pathway

(2010) Connie J. Eaves et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Wnt/ -Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

(2010) Y. Wang et al.   SCIENCE

Epigenetic regulation of WNT signaling in chronic lymphocytic leukemia

(2010) Lynda B Bennett et al.   Epigenomics

Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration

(2009) Wolfram Goessling et al.   CELL

Wnt-Related Molecules and Signaling Pathway Equilibrium in Hematopoiesis

(2009) Sachin Malhotra et al.   Cell Stem Cell

Secreted Frizzled-Related Protein 1 Extrinsically Regulates Cycling Activity and Maintenance of Hematopoietic Stem Cells

(2009) Jonas Renström et al.   Cell Stem Cell

Wnt signaling pathway is epigenetically regulated by methylation of Wnt antagonists in acute myeloid leukemia

(2009) A Valencia et al.   LEUKEMIA

Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation

(2008) T. C. Luis et al.   BLOOD

Epigenetic inactivation of secreted Frizzled-related proteins in acute myeloid leukaemia

(2008) E. Jost et al.   BRITISH JOURNAL OF HAEMATOLOGY

Wnt Signaling in the Niche

(2008) Toshio Suda et al.   CELL

Wnt Signaling in the Niche Enforces Hematopoietic Stem Cell Quiescence and Is Necessary to Preserve Self-Renewal In Vivo

(2008) Heather E. Fleming et al.   Cell Stem Cell

The canonical Wnt signaling pathway plays an important role in lymphopoiesis and hematopoiesis

(2008) Frank J. T. Staal et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Canonical Wnt pathway signaling suppresses VCAM-1 expression by marrow stromal and hematopoietic cells

(2008) Sachin Malhotra et al.   EXPERIMENTAL HEMATOLOGY

Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of  -catenin in mice

(2008) T. Grigoryan et al.   GENES & DEVELOPMENT

The Signaling Protein Wnt4 Enhances Thymopoiesis and Expands Multipotent Hematopoietic Progenitors through β-Catenin-Independent Signaling

(2008) Isabelle Louis et al.   IMMUNITY

β-Catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemia

(2008) Y Hu et al.   LEUKEMIA

Targeting the leukemic stem cell: the Holy Grail of leukemia therapy

(2008) N Misaghian et al.   LEUKEMIA

Signaling pathways governing stem-cell fate

(2007) U. Blank et al.   BLOOD