PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response
Published 2012 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response
Authors
Keywords
-
Journal
LEUKEMIA
Volume 27, Issue 3, Pages 650-660
Publisher
Springer Nature
Online
2012-10-05
DOI
10.1038/leu.2012.285
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia
- (2012) Marcela Braga Mansur et al. BMC CANCER
- Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding Kinetics
- (2012) Qingsong Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: role in cell proliferation and survival
- (2011) Shaunta Guha et al. BASIC RESEARCH IN CARDIOLOGY
- T-cell acute lymphoblastic leukaemia: recent molecular biology findings
- (2011) Monika D. Kraszewska et al. BRITISH JOURNAL OF HAEMATOLOGY
- The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia
- (2011) Teresa Palomero et al. CELL CYCLE
- Progress in the Preclinical Discovery and Clinical Development of Class I and Dual Class I/IV Phosphoinositide 3-Kinase (PI3K) Inhibitors
- (2011) S. J. Shuttleworth et al. CURRENT MEDICINAL CHEMISTRY
- Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL
- (2011) Xiaoyu Li et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia
- (2011) Alejandro Gutierrez et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia
- (2011) C Evangelisti et al. LEUKEMIA
- Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
- (2011) Xose S. Puente et al. NATURE
- A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer
- (2011) Markus K Muellner et al. Nature Chemical Biology
- A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)
- (2011) Konstantinos J Mavrakis et al. NATURE GENETICS
- Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway–dependent and PI3K pathway–independent mechanisms
- (2011) Pixu Liu et al. NATURE MEDICINE
- Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer
- (2011) Dan R Robinson et al. NATURE MEDICINE
- PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis
- (2011) N. Ilic et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells
- (2011) H. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activity of the Novel Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 against T-Cell Acute Lymphoblastic Leukemia
- (2010) F. Chiarini et al. CANCER RESEARCH
- c-Myc Regulates Transcriptional Pause Release
- (2010) Peter B. Rahl et al. CELL
- PIKing the Right Patient
- (2010) A. B. Turke et al. CLINICAL CANCER RESEARCH
- Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase
- (2010) J.-S. Mo et al. JOURNAL OF CELL SCIENCE
- mTOR: from growth signal integration to cancer, diabetes and ageing
- (2010) Roberto Zoncu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- PI3K inhibitors for cancer treatment: where do we stand?
- (2009) Sauveur-Michel Maira et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia
- (2009) A. Gutierrez et al. BLOOD
- FBXW7andNOTCH1mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma
- (2009) Myoung-Ja Park et al. BRITISH JOURNAL OF HAEMATOLOGY
- Dual Inhibition of Class IA Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin as a New Therapeutic Option for T-Cell Acute Lymphoblastic Leukemia
- (2009) F. Chiarini et al. CANCER RESEARCH
- Inhibition of NOTCH Signaling by Gamma Secretase Inhibitor Engages the RB Pathway and Elicits Cell Cycle Exit in T-Cell Acute Lymphoblastic Leukemia Cells
- (2009) S. S. Rao et al. CANCER RESEARCH
- mTOR and cancer: many loops in one pathway
- (2009) Alejo Efeyan et al. CURRENT OPINION IN CELL BIOLOGY
- The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group
- (2009) A Larson Gedman et al. LEUKEMIA
- Identification of novel Notch target genes in T cell leukaemia
- (2009) Nicholas Chadwick et al. Molecular Cancer
- Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy
- (2009) N. T. Ihle et al. MOLECULAR CANCER THERAPEUTICS
- Regulation of Notch1/NICD and Hes1 expressions by GSK-3α/β
- (2009) Yun Hye Jin et al. MOLECULES AND CELLS
- Direct inhibition of the NOTCH transcription factor complex
- (2009) Raymond E. Moellering et al. NATURE
- Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition
- (2009) A. C. Faber et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Notch Signaling in Leukemia
- (2008) Jon C. Aster et al. Annual Review of Pathology-Mechanisms of Disease
- Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases
- (2008) I. Joshi et al. BLOOD
- NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study
- (2008) V. Asnafi et al. BLOOD
- Down-regulation of Notch-dependent transcription by Akt in vitro
- (2008) Jieun Song et al. FEBS LETTERS
- In vitro validation of -secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia
- (2008) K. De Keersmaecker et al. HAEMATOLOGICA
- PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability
- (2008) Ana Silva et al. JOURNAL OF CLINICAL INVESTIGATION
- Proapoptotic Activity and Chemosensitizing Effect of the Novel Akt Inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-Cell Acute Lymphoblastic Leukemia
- (2008) F. Fala et al. MOLECULAR PHARMACOLOGY
- Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation
- (2008) Wei Guo et al. NATURE
- Targeting phosphoinositide 3-kinase—Moving towards therapy
- (2007) Romina Marone et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now