Impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients is associated with a blockade in the deactivation of the Notch signaling pathway

A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function

(2011) S Vallet et al.   LEUKEMIA

High tumor levels of IL6 and IL8 abrogate preclinical efficacy of the γ-secretase inhibitor, RO4929097

(2011) Wei He et al.   Molecular Oncology

HES1 (Hairy and Enhancer of Split 1) Is a Determinant of Bone Mass

(2010) Stefano Zanotti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NOTCHing the bone: Insights into multi-functionality

(2009) Feyza Engin et al.   BONE

Mesenchymal stem cells from multiple myeloma patients display distinct genomic profile as compared with those from normal donors

(2009) M Garayoa et al.   LEUKEMIA

Notch Inhibits Osteoblast Differentiation and Causes Osteopenia

(2008) Stefano Zanotti et al.   ENDOCRINOLOGY

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

(2008) Matthew J Hilton et al.   NATURE MEDICINE