The role of insulin-like growth factors signaling in merlin-deficient human schwannomas

AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

(2011) Sarat Chandarlapaty et al.   CANCER CELL

Emerging therapeutic targets in schwannomas and other merlin-deficient tumors

(2011) Sylwia Ammoun et al.   Nature Reviews Neurology

Nilotinib alone or in combination with selumetinib is a drug candidate for neurofibromatosis type 2

(2011) S. Ammoun et al.   NEURO-ONCOLOGY

Insulin-like growth factor-binding protein-1 (IGFBP-1) regulates human schwannoma proliferation, adhesion and survival

(2011) S Ammoun et al.   ONCOGENE

IGF-1 receptor inhibition by picropodophyllin in medulloblastoma

(2010) Sachiko Ohshima-Hosoyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Merlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus

(2010) Wei Li et al.   CELL

PI3 Kinase and PDK1 in the Regulation of the Electrogenic Intestinal Dipeptide Transport

(2010) Rexhep Rexhepaj et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A Phase I Study of Weekly R1507, A Human Monoclonal Antibody Insulin-like Growth Factor-I Receptor Antagonist, in Patients with Advanced Solid Tumors

(2010) R. Kurzrock et al.   CLINICAL CANCER RESEARCH

ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma

(2010) S. Ammoun et al.   NEURO-ONCOLOGY

Involvement of Src family kinase activation in angiotensin II-induced hyperresponsiveness of rat bronchial smooth muscle

(2010) Hiroyasu Sakai et al.   PEPTIDES

Lysophosphatidic Acid Induces MDA-MB-231 Breast Cancer Cells Migration through Activation of PI3K/PAK1/ERK Signaling

(2010) Jun Du et al.   PLoS One

SUMOylation Mediates the Nuclear Translocation and Signaling of the IGF-1 Receptor

(2010) B. Sehat et al.   Science Signaling

Signal transduction by focal adhesion kinase in cancer

(2009) Jihe Zhao et al.   CANCER AND METASTASIS REVIEWS

Ras activation contributes to the maintenance and expansion of Sca-1pos cells in a mouse model of breast cancer

(2009) Ran-Ju Kim et al.   CANCER LETTERS

Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells

(2009) Tina X. Lee et al.   EUROPEAN JOURNAL OF CANCER

PAK kinase regulates Rac GTPase and is a potential target in human schwannomas

(2009) Christine Flaiz et al.   EXPERIMENTAL NEUROLOGY

Targeting ERK1/2 activation and proliferation in human primary schwannoma cells with MEK1/2 inhibitor AZD6244

(2009) Sylwia Ammoun et al.   NEUROBIOLOGY OF DISEASE

High Expression Levels of Total IGF-1R and Sensitivity of NSCLC Cells In Vitro to an Anti-IGF-1R Antibody (R1507)

(2009) Yixuan Gong et al.   PLoS One

Merlin and the ERM proteins – regulators of receptor distribution and signaling at the cell cortex

(2009) Andrea I. McClatchey et al.   TRENDS IN CELL BIOLOGY

Methylprednisolone inhibits interleukin-17 and interferon-gamma expression by both naive and primed T cells

(2008) Miljana Momčilović et al.   BMC IMMUNOLOGY

Altered Adhesive Structures and Their Relation to RhoGTPase Activation in Merlin-Deficient Schwannoma

(2008) Christine Flaiz et al.   BRAIN PATHOLOGY

Dissecting and Targeting the Growth Factor-Dependent and Growth Factor-Independent Extracellular Signal-Regulated Kinase Pathway in Human Schwannoma

(2008) S. Ammoun et al.   CANCER RESEARCH

Impaired intercellular adhesion and immature adherens junctions in merlin-deficient human primary schwannoma cells

(2008) C. Flaiz et al.   GLIA

Merlin regulates transmembrane receptor accumulation and signaling at the plasma membrane in primary mouse Schwann cells and in human schwannomas

(2008) D Lallemand et al.   ONCOGENE

IGF-1 regulation of type II collagen and MMP-13 expression in rat endplate chondrocytes via distinct signaling pathways

(2008) M. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE