标题
Role of Merlin/NF2 inactivation in tumor biology
作者
关键词
-
出版物
ONCOGENE
Volume 35, Issue 5, Pages 537-548
出版商
Springer Nature
发表日期
2015-04-21
DOI
10.1038/onc.2015.125
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Inhibition of SIRT2 in merlin/NF2-mutant Schwann cells triggers necrosis
- (2015) Alejandra M. Petrilli et al. Oncotarget
- The Neurofibromatosis 2 Tumor Suppressor Gene Product, Merlin, Regulates Human Meningioma Cell Growth by Signaling through YAP
- (2015) Katherine Striedinger et al. NEOPLASIA
- Multistep Phosphorylation by Oncogenic Kinases Enhances the Degradation of the NF2 Tumor Suppressor Merlin
- (2015) Minja Laulajainen et al. NEOPLASIA
- Merlin-Deficient Human Tumors Show Loss of Contact Inhibition and Activation of Wnt/β-Catenin Signaling Linked to the PDGFR/Src and Rac/PAK Pathways
- (2015) Lu Zhou et al. NEOPLASIA
- Functional interdependence of NHE1 and merlin in human melanoma cells
- (2014) Fabian Frontzek et al. Biochemistry and Cell Biology
- Merlin/NF2 Loss-Driven Tumorigenesis Linked to CRL4DCAF1-Mediated Inhibition of the Hippo Pathway Kinases Lats1 and 2 in the Nucleus
- (2014) Wei Li et al. CANCER CELL
- The mammalian Hippo pathway: regulation and function of YAP1 and TAZ
- (2014) Manami Kodaka et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth
- (2014) Boon Chuan Low et al. FEBS LETTERS
- Structural basis of DDB1-and-Cullin 4-associated Factor 1 (DCAF1) recognition by merlin/NF2 and its implication in tumorigenesis by CD44-mediated inhibition of merlin suppression of DCAF1 function
- (2014) Tomoyuki Mori et al. GENES TO CELLS
- A murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formation
- (2014) Jeffrey R. Gehlhausen et al. HUMAN MOLECULAR GENETICS
- Molecular Conformation of the Full-Length Tumor Suppressor NF2/Merlin—A Small-Angle Neutron Scattering Study
- (2014) Jahan Ali Khajeh et al. JOURNAL OF MOLECULAR BIOLOGY
- Gene-expression profiling elucidates molecular signaling networks that can be therapeutically targeted in vestibular schwannoma
- (2014) Sameer Agnihotri et al. JOURNAL OF NEUROSURGERY
- The p53/mouse double minute 2 homolog complex deregulation in merlin-deficient tumours
- (2014) Sylwia Ammoun et al. Molecular Oncology
- Proteomic screening identifies a YAP-driven signaling network linked to tumor cell proliferation in human schwannomas
- (2014) Alizée Boin et al. NEURO-ONCOLOGY
- mTORC1 inhibition delays growth of neurofibromatosis type 2 schwannoma
- (2014) Marco Giovannini et al. NEURO-ONCOLOGY
- The Biology of YAP/TAZ: Hippo Signaling and Beyond
- (2014) Stefano Piccolo et al. PHYSIOLOGICAL REVIEWS
- Nf2/Merlin Controls Spinal Cord Neural Progenitor Function in a Rac1/ErbB2-Dependent Manner
- (2014) Cynthia Garcia et al. PLoS One
- NCI-60 Whole Exome Sequencing and Pharmacological CellMiner Analyses
- (2014) William C. Reinhold et al. PLoS One
- A neuronal function of the tumor suppressor protein merlin
- (2014) Alexander Schulz et al. Acta Neuropathologica Communications
- Intracranial meningiomas and neurofibromatosis type 2
- (2013) Rabih Aboukais et al. ACTA NEUROCHIRURGICA
- Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling
- (2013) Alexander Schulz et al. BRAIN
- High Incidence of ActivatingTERTPromoter Mutations in Meningiomas Undergoing Malignant Progression
- (2013) Stéphane Goutagny et al. BRAIN PATHOLOGY
- Chromosomal structural variations during progression of a prostate epithelial cell line to a malignant metastatic state inactivate the NF2, NIPSNAP1, UGT2B17, and LPIN2 genes
- (2013) Ankit Malhotra et al. CANCER BIOLOGY & THERAPY
- Tumor Suppressor NF2/Merlin Is a Microtubule Stabilizer
- (2013) Z. Smole et al. CANCER RESEARCH
- Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2
- (2013) Feng Yin et al. CELL
- A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors
- (2013) Mariaceleste Aragona et al. CELL
- Merlin isoform 2 in neurofibromatosis type 2–associated polyneuropathy
- (2013) Alexander Schulz et al. NATURE NEUROSCIENCE
- Axl/Gas6/NFκB signalling in schwannoma pathological proliferation, adhesion and survival
- (2013) S Ammoun et al. ONCOGENE
- LIM domain kinases as potential therapeutic targets for neurofibromatosis type 2
- (2013) A Petrilli et al. ONCOGENE
- Regulation of Son of sevenless by the membrane-actin linker protein ezrin
- (2013) K. J. Geissler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
- (2013) Ophir Shalem et al. SCIENCE
- The p130 Isoform of Angiomotin Is Required for Yap-Mediated Hepatic Epithelial Cell Proliferation and Tumorigenesis
- (2013) C. Yi et al. Science Signaling
- Multiple primary intramedullary ependymomas: a case report and review of the literature
- (2013) Mohamad Bydon et al. Spine Journal
- Loss of NF2/Merlin expression in advanced sporadic colorectal cancer
- (2013) Tamara Čačev et al. CELLULAR ONCOLOGY
- Stem cell regulation by the Hippo pathway
- (2012) Samantha E. Hiemer et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Histone Deacetylase Inhibitor AR-42 Differentially Affects Cell-cycle Transit in Meningeal and Meningioma Cells, Potently Inhibiting NF2-Deficient Meningioma Growth
- (2012) S. S. Burns et al. CANCER RESEARCH
- Growth Control by Committee: Intercellular Junctions, Cell Polarity, and the Cytoskeleton Regulate Hippo Signaling
- (2012) Julian C. Boggiano et al. DEVELOPMENTAL CELL
- The Tumor Suppressor Merlin Controls Growth in Its Open State, and Phosphorylation Converts It to a Less-Active More-Closed State
- (2012) Ifat Sher et al. DEVELOPMENTAL CELL
- The role of insulin-like growth factors signaling in merlin-deficient human schwannomas
- (2012) Sylwia Ammoun et al. GLIA
- Regulation of mTOR Complex 2 Signaling in Neurofibromatosis 2-Deficient Target Cell Types
- (2012) M. F. James et al. MOLECULAR CANCER RESEARCH
- Systematic identification of genomic markers of drug sensitivity in cancer cells
- (2012) Mathew J. Garnett et al. NATURE
- Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells
- (2012) Wanjuan Yang et al. NUCLEIC ACIDS RESEARCH
- Lack of Neurofibromatosis Type 2 Gene Promoter Methylation in Sporadic Vestibular Schwannomas
- (2012) D. Koutsimpelas et al. ORL-Journal for Oto-Rhino-Laryngology Head and Neck Surgery
- Investigation of the In Vitro Therapeutic Efficacy of Nilotinib in Immortalized Human NF2-Null Vestibular Schwannoma Cells
- (2012) Nesrin Sabha et al. PLoS One
- Merlin Is a Negative Regulator of Human Melanoma Growth
- (2012) Lucas B. Murray et al. PLoS One
- Regulation of the Hippo pathway by cell architecture and mechanical signals
- (2012) Molly C. Schroeder et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- The Hippo signaling pathway and stem cell biology
- (2012) Azucena Ramos et al. TRENDS IN CELL BIOLOGY
- A Tight Junction-Associated Merlin-Angiomotin Complex Mediates Merlin's Regulation of Mitogenic Signaling and Tumor Suppressive Functions
- (2011) Chunling Yi et al. CANCER CELL
- LATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma
- (2011) H. Murakami et al. CANCER RESEARCH
- Cell–Cell Junctions: α-Catenin and E-Cadherin Help Fence In Yap1
- (2011) Brian S. Robinson et al. CURRENT BIOLOGY
- Hippo pathway regulation by cell morphology and stress fibers
- (2011) K.-I. Wada et al. DEVELOPMENT
- Spinal ependymomas in neurofibromatosis Type 2: a retrospective analysis of 55 patients
- (2011) Scott R. Plotkin et al. JOURNAL OF NEUROSURGERY-SPINE
- Preclinical validation of AR42, a novel histone deacetylase inhibitor, as treatment for vestibular schwannomas
- (2011) Abraham Jacob et al. LARYNGOSCOPE
- Role of YAP/TAZ in mechanotransduction
- (2011) Sirio Dupont et al. NATURE
- The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
- (2011) Bin Zhao et al. NATURE CELL BIOLOGY
- Nilotinib alone or in combination with selumetinib is a drug candidate for neurofibromatosis type 2
- (2011) S. Ammoun et al. NEURO-ONCOLOGY
- AR42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomas
- (2011) M. L. Bush et al. NEURO-ONCOLOGY
- PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling
- (2011) Y Shrestha et al. ONCOGENE
- Mutational analysis of tumour suppressor gene NF2 in common solid cancers and acute leukaemias
- (2011) Nam Jin Yoo et al. PATHOLOGY
- Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor
- (2011) S. D. Yogesha et al. PROTEIN SCIENCE
- Merlin/NF2 Functions Upstream of the Nuclear E3 Ubiquitin Ligase CRL4DCAF1 to Suppress Oncogenic Gene Expression
- (2011) J. Cooper et al. Science Signaling
- Merlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus
- (2010) Wei Li et al. CELL
- Ependymomas in Adults
- (2010) Mark R. Gilbert et al. Current Neurology and Neuroscience Reports
- Merlin, a “Magic” Linker Between the Extracellular Cues and Intracellular Signaling Pathways that Regulate Cell Motility, Proliferation, and Survival
- (2010) Ivan Stamenkovic et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals
- (2010) Nailing Zhang et al. DEVELOPMENTAL CELL
- The Hippo Signaling Pathway in Development and Cancer
- (2010) Duojia Pan DEVELOPMENTAL CELL
- Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver
- (2010) S. Benhamouche et al. GENES & DEVELOPMENT
- Meningioma mouse models
- (2010) Michel Kalamarides et al. JOURNAL OF NEURO-ONCOLOGY
- Epidemiology and etiology of meningioma
- (2010) Joseph Wiemels et al. JOURNAL OF NEURO-ONCOLOGY
- Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
- (2010) Ramin Nazarian et al. NATURE
- ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma
- (2010) S. Ammoun et al. NEURO-ONCOLOGY
- Overexpression of ezrin inactivates NF2 tumor suppressor in glioblastoma
- (2010) F. C. Morales et al. NEURO-ONCOLOGY
- NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation
- (2010) E E Bosco et al. ONCOGENE
- Merlin Knockdown in Human Schwann Cells
- (2010) Zana Ahmad et al. OTOLOGY & NEUROTOLOGY
- Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants
- (2010) L. B. Bensenor et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
- (2010) H. Song et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
- (2010) L. Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene
- (2009) Dawang Zhou et al. CANCER CELL
- Human Schwannomas Express Activated Platelet-Derived Growth Factor Receptors and c-kit and Are Growth Inhibited by Gleevec (Imatinib Mesylate)
- (2009) J. Mukherjee et al. CANCER RESEARCH
- Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells
- (2009) Tina X. Lee et al. EUROPEAN JOURNAL OF CANCER
- Activation of ERK, AKT and JNK signalling pathways in human schwannomasin situ
- (2009) David A Hilton et al. HISTOPATHOLOGY
- Neurofibromatosis type 2
- (2009) Ashok R Asthagiri et al. LANCET
- Fluorescence Resonance Energy Transfer Analysis of Merlin Conformational Changes
- (2009) R. F. Hennigan et al. MOLECULAR AND CELLULAR BIOLOGY
- Loss of the Tumor Suppressor Gene NF2, Encoding Merlin, Constitutively Activates Integrin-Dependent mTORC1 Signaling
- (2009) M. A. Lopez-Lago et al. MOLECULAR AND CELLULAR BIOLOGY
- NF2/Merlin Is a Novel Negative Regulator of mTOR Complex 1, and Activation of mTORC1 Is Associated with Meningioma and Schwannoma Growth
- (2009) M. F. James et al. MOLECULAR AND CELLULAR BIOLOGY
- Neurofibromatosis type 2 (NF2): A clinical and molecular review
- (2009) D Gareth R Evans Orphanet Journal of Rare Diseases
- Phosphatidylinositol 3-Kinase/AKT Pathway Activation in Human Vestibular Schwannoma
- (2009) Abraham Jacob et al. OTOLOGY & NEUROTOLOGY
- Altered Adhesive Structures and Their Relation to RhoGTPase Activation in Merlin-Deficient Schwannoma
- (2008) Christine Flaiz et al. BRAIN PATHOLOGY
- Dissecting and Targeting the Growth Factor-Dependent and Growth Factor-Independent Extracellular Signal-Regulated Kinase Pathway in Human Schwannoma
- (2008) S. Ammoun et al. CANCER RESEARCH
- Merlin Is a Potent Inhibitor of Glioma Growth
- (2008) Y.-K. I. Lau et al. CANCER RESEARCH
- YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation
- (2008) Toshihiko Yokoyama et al. CARCINOGENESIS
- Nf2/Merlin Regulates Hematopoietic Stem Cell Behavior by Altering Microenvironmental Architecture
- (2008) Jonas Larsson et al. Cell Stem Cell
- Impaired intercellular adhesion and immature adherens junctions in merlin-deficient human primary schwannoma cells
- (2008) C. Flaiz et al. GLIA
- Functional inactivation of NF2/merlin in human mesothelioma
- (2008) Claudio Thurneysen et al. LUNG CANCER
- The Neurofibromatosis 2 Protein, Merlin, Regulates Glial Cell Growth in an ErbB2- and Src-Dependent Manner
- (2008) S. S. Houshmandi et al. MOLECULAR AND CELLULAR BIOLOGY
- Merlin regulates transmembrane receptor accumulation and signaling at the plasma membrane in primary mouse Schwann cells and in human schwannomas
- (2008) D Lallemand et al. ONCOGENE
- Inactivation of the NF2 tumor suppressor protein merlin in DU145 prostate cancer cells
- (2008) Akio Horiguchi et al. PROSTATE
- Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma
- (2008) Tim F Cloughesy et al. PLOS MEDICINE
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