PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling

The frequent co-expression of the oncogenes PIK3CA and PAK1 in oral carcinomas

(2011) Hsi-Feng Tu et al.   ORAL ONCOLOGY

Rac1 and Cdc42 are regulators of HRasV12-transformation and angiogenic factors in human fibroblasts

(2010) Daniel M Appledorn et al.   BMC CANCER

PIK3CA Mutations in In situ and Invasive Breast Carcinomas

(2010) A. Miron et al.   CANCER RESEARCH

Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India

(2010) Indranil Chattopadhyay et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

(2010) Cory M. Johannessen et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

MET signalling: principles and functions in development, organ regeneration and cancer

(2010) Livio Trusolino et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Rac–Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells

(2010) L E Arias-Romero et al.   ONCOGENE

CK1ε Is Required for Breast Cancers Dependent on β-Catenin Activity

(2010) So Young Kim et al.   PLoS One

Pak protein kinases and their role in cancer

(2009) Bettina Dummler et al.   CANCER AND METASTASIS REVIEWS

Basal Subtype and MAPK/ERK Kinase (MEK)-Phosphoinositide 3-Kinase Feedback Signaling Determine Susceptibility of Breast Cancer Cells to MEK Inhibition

(2009) O. K. Mirzoeva et al.   CANCER RESEARCH

In vivo Antitumor Activity of MEK and Phosphatidylinositol 3-Kinase Inhibitors in Basal-Like Breast Cancer Models

(2009) K. P. Hoeflich et al.   CLINICAL CANCER RESEARCH

ErbB receptors and signaling pathways in cancer

(2009) Nancy E Hynes et al.   CURRENT OPINION IN CELL BIOLOGY

Non-redundancy within the RAS oncogene family: Insights into mutational disparities in cancer

(2009) Ken S. Lau et al.   MOLECULES AND CELLS

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

(2009) M. L. Sos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amplification of 11q13 in ovarian carcinoma

(2008) Lindsay A. Brown et al.   GENES CHROMOSOMES & CANCER

Characterization of Ser338Phosphorylation for Raf-1 Activation

(2008) Mengwei Zang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy

(2008) Jinyan Du et al.   NATURE BIOTECHNOLOGY

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

(2008) Jeffrey A Engelman et al.   NATURE MEDICINE