Emerging roles of Myc in stem cell biology and novel tumor therapies

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth

(2018) Mami Morita et al.   CANCER CELL

Enhancer reprogramming in tumor progression: a new route towards cancer cell plasticity

(2018) Luca Fagnocchi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Current and future therapeutic approaches for the treatment of small cell lung cancer

(2018) Antonio Rossi et al.   Expert Review of Anticancer Therapy

Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism

(2018) Qingqiu Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

(2018) Marc L Hyer et al.   NATURE MEDICINE

Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis

(2018) Andras Ladanyi et al.   ONCOGENE

Thymidine phosphorylase in cancer aggressiveness and chemoresistance

(2018) Tatsuhiko Furukawa et al.   PHARMACOLOGICAL RESEARCH

Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid

(2018) Xian-Yang Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How to eliminate MYCN-positive hepatic cancer stem cells to prevent the recurrence?

(2018) Go J. Yoshida   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Epithelial Sodium Channel (αENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors

(2018) Min He et al.   Translational Oncology

Metabolic Hallmarks of Metastasis Formation

(2018) Ilaria Elia et al.   TRENDS IN CELL BIOLOGY

MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state

(2018) Vittoria Poli et al.   Nature Communications

The Expanding World of N-MYC–Driven Tumors

(2018) David S. Rickman et al.   Cancer Discovery

MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma

(2018) Saurabh Agarwal et al.   Oncotarget

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

(2018) Amy Tarangelo et al.   Cell Reports

Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment

(2017) Go J. Yoshida   Journal of Hematology & Oncology

Biology and evolution of poorly differentiated neuroendocrine tumors

(2017) David S Rickman et al.   NATURE MEDICINE

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner

(2017) D Chen et al.   ONCOGENE

E3 ubiquitin ligase FBW7α inhibits cholangiocarcinoma cell proliferation by downregulating c-Myc and cyclin E

(2017) Ming Li et al.   ONCOLOGY REPORTS

Treatment advances in small cell lung cancer (SCLC)

(2017) Saiama N. Waqar et al.   PHARMACOLOGY & THERAPEUTICS

Targeting Free Radicals in Oxidative Stress-Related Human Diseases

(2017) Patrik Poprac et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Proteasome expression and activity in cancer and cancer stem cells

(2017) Ioannis A Voutsadakis   TUMOR BIOLOGY

Glutaminase inhibitor CB-839 synergizes with carfilzomib in resistant multiple myeloma cells

(2017) Ravyn M. Thompson et al.   Oncotarget

Glutamine Transport and Mitochondrial Metabolism in Cancer Cell Growth

(2017) Mariafrancesca Scalise et al.   Frontiers in Oncology

The Warburg effect: 80 years on

(2016) Michelle Potter et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Prognostic impact of CD44-positive cancer stem-like cells at the invasive front of gastric cancer

(2016) Hirokazu Kodama et al.   BRITISH JOURNAL OF CANCER

N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer

(2016) Etienne Dardenne et al.   CANCER CELL

N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells

(2016) John K. Lee et al.   CANCER CELL

To wake up cancer stem cells, or to let them sleep, that is the question

(2016) Shoichiro Takeishi et al.   CANCER SCIENCE

Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause

(2016) Roberta Scognamiglio et al.   CELL

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Clinical and Biologic Significance of MYC Genetic Mutations in De Novo Diffuse Large B-cell Lymphoma

(2016) Z. Y. Xu-Monette et al.   CLINICAL CANCER RESEARCH

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

(2016) Roman Camarda et al.   NATURE MEDICINE

OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors

(2016) L A Jung et al.   ONCOGENE

The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis

(2016) Bernhard Mlecnik et al.   Science Translational Medicine

Fbw7 and its counteracting forces in stem cells and cancer: Oncoproteins in the balance

(2016) Catherine A. Cremona et al.   SEMINARS IN CANCER BIOLOGY

Regulating Fbw7 on the road to cancer

(2016) Wenshan Xu et al.   SEMINARS IN CANCER BIOLOGY

PKM2 and cancer: The function of PKM2 beyond glycolysis

(2016) GAOCHAO DONG et al.   Oncology Letters

Glutaminolysis gets the spotlight in cancer

(2016) Daniel Herranz   Oncotarget

BET Bromodomain Inhibition Releases the Mediator Complex from Select cis -Regulatory Elements

(2016) Anand S. Bhagwat et al.   Cell Reports

A c-Myc/miR17-92/Pten Axis Controls PI3K-Mediated Positive and Negative Selection in B Cell Development and Reconstitutes CD19 Deficiency

(2016) David Benhamou et al.   Cell Reports

Myc and cell cycle control

(2015) Gabriel Bretones et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis

(2015) Patrick A. Carroll et al.   CANCER CELL

Functional interplay between MYCN, NCYM, and OCT4 promotes aggressiveness of human neuroblastomas

(2015) Yoshiki Kaneko et al.   CANCER SCIENCE

Therapeutic strategies targeting cancer stem cells

(2015) Go J. Yoshida et al.   CANCER SCIENCE

Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma

(2015) Deepanwita Sengupta et al.   Epigenetics

Regulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin Ligases

(2015) Vinayak Vittal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner

(2015) Kanae Yumimoto et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic reprogramming: the emerging concept and associated therapeutic strategies

(2015) Go J. Yoshida   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The c-Myc–LDHA axis positively regulates aerobic glycolysis and promotes tumor progression in pancreatic cancer

(2015) Tian-Lin He et al.   MEDICAL ONCOLOGY

Glutaminolysis as a target for cancer therapy

(2015) L Jin et al.   ONCOGENE

Clinical development of cancer therapeutics that target metabolism

(2015) B.F. Clem et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Dysregulated metabolism contributes to oncogenesis

(2015) Matthew D. Hirschey et al.   SEMINARS IN CANCER BIOLOGY

Metabolic reprogramming in cancer cells: glycolysis, glutaminolysis, and Bcl-2 proteins as novel therapeutic targets for cancer

(2015) Chunxia Li et al.   World Journal of Surgical Oncology

Reactivation of p53 via MDM2 inhibition

(2015) E S Kim et al.   Cell Death & Disease

Concurrent AURKA and MYCN Gene Amplifications Are Harbingers of Lethal TreatmentRelated Neuroendocrine Prostate Cancer

(2015) Juan Miguel Mosquera et al.   NEOPLASIA

Metabolic characterization of triple negative breast cancer

(2014) Maria D Cao et al.   BMC CANCER

Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells

(2014) S Takeishi et al.   BRITISH JOURNAL OF CANCER

Control of nucleotide biosynthesis by the MYC oncoprotein: Old friends get reacquainted

(2014) Steven B. McMahon   CELL CYCLE

miR-17-92 Cluster Targets Phosphatase and Tensin Homology and Ikaros Family Zinc Finger 4 to Promote TH17-mediated Inflammation

(2014) Si-Qi Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

Regulation and Role of EZH2 in Cancer

(2014) Hirohito Yamaguchi et al.   Cancer Research and Treatment

MYC and Mitochondrial Biogenesis

(2014) F. Morrish et al.   Cold Spring Harbor Perspectives in Medicine

NCYM, a Cis-Antisense Gene of MYCN, Encodes a De Novo Evolved Protein That Inhibits GSK3β Resulting in the Stabilization of MYCN in Human Neuroblastomas

(2014) Yusuke Suenaga et al.   PLoS Genetics

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation

(2013) Go J. Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc

(2013) Kenta Masui et al.   Cell Metabolism

Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases

(2013) Weihua Zhou et al.   CELL RESEARCH

Role of SKP1-CUL1-F-Box-Protein (SCF) E3 Ubiquitin Ligases in Skin Cancer

(2013) Chuan-Ming Xie et al.   Journal of Genetics and Genomics

Histone deacetylase inhibitor potentiated the ability of MTOR inhibitor to induce autophagic cell death in Burkitt leukemia/lymphoma

(2013) Li Dong et al.   Journal of Hematology & Oncology

Molecular regulation of stem cell quiescence

(2013) Tom H. Cheung et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting Neuroblastoma Stem Cells with Retinoic Acid and Proteasome Inhibitor

(2013) Barbara Hämmerle et al.   PLoS One

NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM

(2013) J. K. Osborne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer stem cell characteristics, ALDH1 expression in the invasive front of nasopharyngeal carcinoma

(2013) Wei-ren Luo et al.   VIRCHOWS ARCHIV

Control of Vertebrate Development by MYC

(2013) P. J. Hurlin   Cold Spring Harbor Perspectives in Medicine

MYC, Metabolism, Cell Growth, and Tumorigenesis

(2013) C. V. Dang   Cold Spring Harbor Perspectives in Medicine

Modulation of Glucose Metabolism by CD44 Contributes to Antioxidant Status and Drug Resistance in Cancer Cells

(2012) M. Tamada et al.   CANCER RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Pyruvate Kinase M2: Multiple Faces for Conferring Benefits on Cancer Cells

(2012) M. Tamada et al.   CLINICAL CANCER RESEARCH

Tumor suppressor functions of FBW7 in cancer development and progression

(2012) Zhiwei Wang et al.   FEBS LETTERS

A Positive Feedback Loop Regulates the Expression of Polycomb Group Protein BMI1 via WNT Signaling Pathway

(2012) Joon-Ho Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression

(2012) Jan J Molenaar et al.   NATURE GENETICS

Krüppel-like factor 4 (KLF4) suppresses neuroblastoma cell growth and determines non-tumorigenic lineage differentiation

(2012) C K Y Shum et al.   ONCOGENE

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

(2012) W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell

(2012) Toshifumi Yae et al.   Nature Communications

MYCN: from oncoprotein to tumor-associated antigen

(2012) Vito Pistoia et al.   Frontiers in Oncology

Role of the ubiquitin ligase Fbw7 in cancer progression

(2011) Yabin Cheng et al.   CANCER AND METASTASIS REVIEWS

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung

(2011) Zvi Granot et al.   CANCER CELL

CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

(2011) Takatsugu Ishimoto et al.   CANCER CELL

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry

(2011) Fionnuala Morrish et al.   CELL CYCLE

Oct-4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells

(2011) Annalisa Pezzolo et al.   CELL RESEARCH

Indefinite Self-Renewal of ESCs through Myc/Max Transcriptional Complex-Independent Mechanisms

(2011) Tomoaki Hishida et al.   Cell Stem Cell

p57 Is Required for Quiescence and Maintenance of Adult Hematopoietic Stem Cells

(2011) Akinobu Matsumoto et al.   Cell Stem Cell

Breaking the Cell Cycle of HSCs by p57 and Friends

(2011) Melania Tesio et al.   Cell Stem Cell

Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: An orally active anti-cancer drug waiting for its call-of-duty?

(2011) Hayden Matthews et al.   INTERNATIONAL JOURNAL OF CANCER

CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression

(2011) Rhonda L. Brown et al.   JOURNAL OF CLINICAL INVESTIGATION

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

(2011) Hiroyuki Inuzuka et al.   NATURE

The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation

(2011) Allan M. Weissman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets

(2011) H. Beltran et al.   Cancer Discovery

miR-17–92 cluster: ups and downs in cancer and aging

(2010) Johannes Grillari et al.   BIOGERONTOLOGY

Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells

(2010) Keriayn N. Smith et al.   Cell Stem Cell

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

myc maintains embryonic stem cell pluripotency and self-renewal

(2010) Natalia V. Varlakhanova et al.   DIFFERENTIATION

WD40 Repeat Propellers Define a Ubiquitin-Binding Domain that Regulates Turnover of F Box Proteins

(2010) Natasha Pashkova et al.   MOLECULAR CELL

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY

Promotion of direct reprogramming by transformation-deficient Myc

(2010) M. Nakagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53-Altered FBXW7 Expression Determines Poor Prognosis in Gastric Cancer Cases

(2009) T. Yokobori et al.   CANCER RESEARCH

CD44+slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2in gastric tumorigenesis

(2009) Takatsugu Ishimoto et al.   CANCER SCIENCE

Role of the Murine Reprogramming Factors in the Induction of Pluripotency

(2009) Rupa Sridharan et al.   CELL

iPS Programmed Without c-MYC Yield Proficient Cardiogenesis for Functional Heart Chimerism

(2009) Almudena Martinez-Fernandez et al.   CIRCULATION RESEARCH

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

(2009) C. V. Dang et al.   CLINICAL CANCER RESEARCH

Single-cell transcript analysis of human embryonic stem cells

(2009) Jason D. Gibson et al.   Integrative Biology

Outcome Prediction in Pediatric Medulloblastoma Based on DNA Copy-Number Aberrations of Chromosomes 6q and 17q and theMYCandMYCNLoci

(2009) Stefan Pfister et al.   JOURNAL OF CLINICAL ONCOLOGY

New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer

(2009) Shundong Cang et al.   Journal of Hematology & Oncology

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon

(2009) Kosuke Yusa et al.   NATURE METHODS

Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts

(2009) K Masuda et al.   ONCOGENE

Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences

(2009) J. Yu et al.   SCIENCE

Anoikis resistance and tumor metastasis

(2008) Craig D. Simpson et al.   CANCER LETTERS

Mcl-1 is a potential therapeutic target in multiple types of cancer

(2008) C. Akgul   CELLULAR AND MOLECULAR LIFE SCIENCES

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL

(2008) S. Matsuoka et al.   GENES & DEVELOPMENT

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Transcription-independent functions of MYC: regulation of translation and DNA replication

(2008) Michael D. Cole et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Notch-dependent cell cycle arrest and apoptosis in mouse embryonic fibroblasts lacking Fbxw7

(2008) Y Ishikawa et al.   ONCOGENE

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced Pluripotent Stem Cells Generated Without Viral Integration

(2008) M. Stadtfeld et al.   SCIENCE

Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors

(2008) K. Okita et al.   SCIENCE

Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas

(2008) Frank Westermann et al.   GENOME BIOLOGY