Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism

Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators

(2017) Clint A. Stalnecker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis

(2017) Qiyu Feng et al.   Nature Communications

Design and evaluation of novel glutaminase inhibitors

(2016) Lee A. McDermott et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mechanistic Basis of Glutaminase Activation

(2016) Yunxing Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy

(2016) Michael J. Lukey et al.   Nature Communications

Structural basis for exploring the allosteric inhibition of human kidney type glutaminase

(2016) Sarath Ramachandran et al.   Oncotarget

Reduction of lattice disorder in protein crystals by high-pressure cryocooling

(2016) Qingqiu Huang et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Glutaminase: A Hot Spot For Regulation Of Cancer Cell Metabolism?

(2015)   Oncotarget

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

Simultaneously Targeting Tissue Transglutaminase and Kidney Type Glutaminase Sensitizes Cancer Cells to Acid Toxicity and Offers New Opportunities for Therapeutic Intervention

(2014) William P. Katt et al.   MOLECULAR PHARMACEUTICS

Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells

(2014) Clint A. Stalnecker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase Isoenzymes as Key Regulators in Metabolic and Oxidative Stress Against Cancer

(2013) J.M. Mates et al.   CURRENT MOLECULAR MEDICINE

Therapeutic strategies impacting cancer cell glutamine metabolism

(2013) Michael J Lukey et al.   Future Medicinal Chemistry

Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor

(2013) Amanda Petrina Scotá Ferreira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of glutamine dependency in non-small cell lung cancer

(2012) A. Pieter J. van den Heuvel et al.   CANCER BIOLOGY & THERAPY

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

(2012) Anne Le et al.   Cell Metabolism

Design, Synthesis, and Pharmacological Evaluation of Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl Sulfide 3 (BPTES) Analogs as Glutaminase Inhibitors

(2012) Krupa Shukla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dibenzophenanthridines as Inhibitors of Glutaminase C and Cancer Cell Proliferation

(2012) William P. Katt et al.   MOLECULAR CANCER THERAPEUTICS

Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism

(2012) K. Thangavelu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism

(2012) A. Cassago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Full-Length Human Glutaminase in Complex with an Allosteric Inhibitor

(2011) Byron DeLaBarre et al.   BIOCHEMISTRY

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

(2011) Yoko S DeRose et al.   NATURE MEDICINE

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

Rethinking the Warburg Effect with Myc Micromanaging Glutamine Metabolism

(2010) C. V. Dang   CANCER RESEARCH

Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1

(2010) M. J. Seltzer et al.   CANCER RESEARCH

Microcrystallography, high-pressure cryocooling and BioSAXS at MacCHESS

(2010) Ulrich Englich et al.   JOURNAL OF SYNCHROTRON RADIATION

The Warburg effect and mitochondrial stability in cancer cells

(2009) Vladimir Gogvadze et al.   MOLECULAR ASPECTS OF MEDICINE

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE