Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma

BET Protein Inhibitor JQ1 Attenuates Myc-Amplified MCC Tumor Growth In Vivo

(2014) Q. Shao et al.   CANCER RESEARCH

Enhancer RNAs: the new molecules of transcription

(2014) Fan Lai et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Relationships among primary tumor size, number of involved nodes, and survival for 8044 cases of Merkel cell carcinoma

(2014) Jayasri G. Iyer et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition

(2014) Junwei Shi et al.   MOLECULAR CELL

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

(2014) Irfan A. Asangani et al.   NATURE

Targeting bromodomains: epigenetic readers of lysine acetylation

(2014) Panagis Filippakopoulos et al.   NATURE REVIEWS DRUG DISCOVERY

Long-range enhancer activity determinesMycsensitivity to Notch inhibitors in T cell leukemia

(2014) Yumi Yashiro-Ohtani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

(2014) M. R. Mansour et al.   SCIENCE

Enhancer RNAs and regulated transcriptional programs

(2014) Michael T.Y. Lam et al.   TRENDS IN BIOCHEMICAL SCIENCES

Control of Embryonic Stem Cell Identity by BRD4-Dependent Transcriptional Elongation of Super-Enhancer-Associated Pluripotency Genes

(2014) Raffaella Di Micco et al.   Cell Reports

Chronic mTOR activation promotes cell survival in Merkel cell carcinoma

(2013) Zhenyu Lin et al.   CANCER LETTERS

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Merkel Cell Polyomavirus Small T Antigen Controls Viral Replication and Oncoprotein Expression by Targeting the Cellular Ubiquitin Ligase SCFFbw7

(2013) Hyun Jin Kwun et al.   Cell Host & Microbe

Pathologic Characteristics of NUT Midline Carcinoma Arising in the Mediastinum

(2012) Andrew G. Evans et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Bromodomain-containing Protein 4 (BRD4) Regulates RNA Polymerase II Serine 2 Phosphorylation in Human CD4+ T Cells

(2012) Weishi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Gene Expression Profiles of Viral- and Nonviral-Associated Merkel Cell Carcinoma Revealed by Transcriptome Analysis

(2012) Paul W. Harms et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Activation of the PI3K/AKT Pathway in Merkel Cell Carcinoma

(2012) Christian Hafner et al.   PLoS One

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Transcriptome-Wide Studies of Merkel Cell Carcinoma and Validation of Intratumoral CD8+ Lymphocyte Invasion As an Independent Predictor of Survival

(2011) Kelly G. Paulson et al.   JOURNAL OF CLINICAL ONCOLOGY

Merkel Cell Polyomavirus Status Is Not Associated with Clinical Course of Merkel Cell Carcinoma

(2011) David Schrama et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Enhancers make non-coding RNA

(2010) Bing Ren   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation

(2009) Diana C. Hargreaves et al.   CELL

Histone Crosstalk between H3S10ph and H4K16ac Generates a Histone Code that Mediates Transcription Elongation

(2009) Alessio Zippo et al.   CELL

Array-CGH Reveals Recurrent Genomic Changes in Merkel Cell Carcinoma Including Amplification of L-Myc

(2008) Kelly G. Paulson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY