Role of the ubiquitin ligase Fbw7 in cancer progression

MYC and Metastasis

(2011) A. Wolfer et al.   CANCER RESEARCH

Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress

(2011) Akinobu Matsumoto et al.   CANCER SCIENCE

MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression

(2011) Mikael Lerner et al.   CELL CYCLE

PI3K-dependent phosphorylation of Fbw7 modulates substrate degradation and activity

(2011) Christina Schülein et al.   FEBS LETTERS

Fbxw7-dependent Degradation of Notch Is Required for Control of “Stemness” and Neuronal-Glial Differentiation in Neural Stem Cells

(2011) Akinobu Matsumoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

(2011) Hiroyuki Inuzuka et al.   NATURE

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

Regulation of the tumour suppressor Fbw7α by PKC-dependent phosphorylation and cancer-associated mutations

(2010) Joanne Durgan et al.   BIOCHEMICAL JOURNAL

The Fbw7 Tumor Suppressor Targets KLF5 for Ubiquitin-Mediated Degradation and Suppresses Breast Cell Proliferation

(2010) Dong Zhao et al.   CANCER RESEARCH

The tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis

(2010) Kuppusamy Balamurugan et al.   EMBO JOURNAL

MicroRNA-223 Regulates Cyclin E Activity by Modulating Expression of F-box and WD-40 Domain Protein 7

(2010) Yanfei Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation

(2010) F. Galli et al.   JOURNAL OF CELL SCIENCE

Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase

(2010) J.-S. Mo et al.   JOURNAL OF CELL SCIENCE

Ubiquitylation of the amino terminus of Myc by SCFβ-TrCP antagonizes SCFFbw7-mediated turnover

(2010) Nikita Popov et al.   NATURE CELL BIOLOGY

Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun

(2010) Joerg D Hoeck et al.   NATURE NEUROSCIENCE

Tumor suppressor Fbxw7 regulates TGFβ signaling by targeting TGIF1 for degradation

(2010) M T Bengoechea-Alonso et al.   ONCOGENE

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

(2010) V Rocher-Ros et al.   ONCOGENE

The ubiquitous nature of cancer: the role of the SCFFbw7 complex in development and transformation

(2010) K M Crusio et al.   ONCOGENE

C/EBP  targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression

(2010) S. A. Pawar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Krüppel-like factor (KLF) 5 mediates cyclin D1 expression and cell proliferation via interaction with c-Jun in Ang II-induced VSMCs

(2009) Yu Liu et al.   ACTA PHARMACOLOGICA SINICA

A Nanoparticle System Specifically Designed to Deliver Short Interfering RNA Inhibits Tumor Growth In vivo

(2009) N. Yagi et al.   CANCER RESEARCH

Adenovirus E1A Inhibits SCFFbw7Ubiquitin Ligase

(2009) Tomoyasu Isobe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group

(2009) A Larson Gedman et al.   LEUKEMIA

Allelic imbalance sequencing reveals that single-nucleotide polymorphisms frequently alter microRNA-directed repression

(2009) Jinkuk Kim et al.   NATURE BIOTECHNOLOGY

Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb

(2009) K Kitagawa et al.   ONCOGENE

Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1

(2009) H -Q Zheng et al.   ONCOGENE

Targeting Proteins for Destruction by the Ubiquitin System: Implications for Human Pathobiology

(2008) Alan L. Schwartz et al.   Annual Review of Pharmacology and Toxicology

The Fbxw7/hCdc4 tumor suppressor in human cancer

(2008) YingMeei Tan et al.   CANCER LETTERS

The role of mTOR in the management of solid tumors: An overview

(2008) Alex S. Strimpakos et al.   CANCER TREATMENT REVIEWS

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL

(2008) S. Matsuoka et al.   GENES & DEVELOPMENT

Fbxw7 Acts as an E3 Ubiquitin Ligase That Targets c-Myb for Nemo-like Kinase (NLK)-induced Degradation

(2008) Chie Kanei-Ishii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isoform- and cell cycle–dependent substrate degradation by the Fbw7 ubiquitin ligase

(2008) Jonathan E. Grim et al.   JOURNAL OF CELL BIOLOGY

Notch-dependent cell cycle arrest and apoptosis in mouse embryonic fibroblasts lacking Fbxw7

(2008) Y Ishikawa et al.   ONCOGENE

Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug-induced polyploidy

(2008) S Finkin et al.   ONCOGENE

It's T-ALL about Notch

(2008) R M Demarest et al.   ONCOGENE

FBXW7 Targets mTOR for Degradation and Cooperates with PTEN in Tumor Suppression

(2008) Jian-Hua Mao et al.   SCIENCE