Sirtuin 6 inhibits myofibroblast differentiation via inactivating transforming growth factor-β1/Smad2 and nuclear factor-κB signaling pathways in human fetal lung fibroblasts

TNF-α-induced NF-κB activation promotes myofibroblast differentiation of LR-MSCs and exacerbates bleomycin-induced pulmonary fibrosis

(2017) Jiwei Hou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

HMGB1 induces lung fibroblast to myofibroblast differentiation through NF-κB-mediated TGF-β1 release

(2017) Qiong Wang et al.   Molecular Medicine Reports

Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-β1/Smad3 signaling

(2017) Kunming Tian et al.   Oncotarget

Sirt6 regulates dendritic cell differentiation, maturation, and function

(2016) Denise Lasigliè et al.   Aging-US

TGF-β1 activates the canonical NF-κB signaling to promote cell survival and proliferation in dystrophic muscle fibroblasts in vitro

(2016) Zhen-Yu Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Idiopathic Pulmonary Fibrosis: A Genetic Disease That Involves Mucociliary Dysfunction of the Peripheral Airways

(2016) Christopher M. Evans et al.   PHYSIOLOGICAL REVIEWS

Nuclear factor (NF)-κB p65 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-β

(2015) Xia Sun et al.   LIFE SCIENCES

The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine

(2015) Jean-Pierre Etchegaray et al.   NATURE CELL BIOLOGY

Sirtuin-6 inhibits cardiac fibroblasts differentiation into myofibroblasts via inactivation of nuclear factor κB signaling

(2015) Kunming Tian et al.   Translational Research

Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development

(2015) Yaosen Wu et al.   Scientific Reports

TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice

(2014) Shaik O. Rahaman et al.   JOURNAL OF CLINICAL INVESTIGATION

Blockade of IL-6TransSignaling Attenuates Pulmonary Fibrosis

(2014) Thanh-Thuy T. Le et al.   JOURNAL OF IMMUNOLOGY

Chromatin and beyond: the multitasking roles for SIRT6

(2014) Sita Kugel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular Basis of NF-κB Signaling

(2013) Johanna Napetschnig et al.   Annual Review of Biophysics

25-Hydroxycholesterol promotes fibroblast-mediated tissue remodeling through NF-κB dependent pathway

(2013) Tomohiro Ichikawa et al.   EXPERIMENTAL CELL RESEARCH

Berberine attenuates bleomycin induced pulmonary toxicity and fibrosis via suppressing NF-κB dependant TGF-β activation: A biphasic experimental study

(2013) Palanivel Chitra et al.   TOXICOLOGY LETTERS

Hydrogen sulfide protects against bleomycin-induced pulmonary fibrosis in rats by inhibiting NF-κB expression and regulating Th1/Th2 balance

(2013) Hua Cao et al.   TOXICOLOGY LETTERS

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

STAT3-Mediated Signaling Dysregulates Lung Fibroblast-Myofibroblast Activation and Differentiation in UIP/IPF

(2012) Dmitri V. Pechkovsky et al.   AMERICAN JOURNAL OF PATHOLOGY

Sirtuin 6 protects cardiomyocytes from hypertrophyin vitrovia inhibition of NF-κB-dependent transcriptional activity

(2012) Shan-Shan Yu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Progression of Chronic Liver Inflammation and Fibrosis Driven by Activation of c-JUN Signaling inSirt6Mutant Mice

(2012) Cuiying Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

(2012) Nagalingam R Sundaresan et al.   NATURE MEDICINE

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

Myofibroblast differentiation and survival in fibrotic disease

(2011) Kornelia Kis et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

TGF-β signaling in fibrosis

(2011) Anna Biernacka et al.   GROWTH FACTORS

Idiopathic pulmonary fibrosis

(2011) Talmadge E King et al.   LANCET

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells

(2010) Shunsuke Minagawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Peroxisome Proliferator-Activated Receptor-  Activation Inhibits Tumor Metastasis by Antagonizing Smad3-Mediated Epithelial-Mesenchymal Transition

(2010) A. K. Reka et al.   MOLECULAR CANCER THERAPEUTICS

Electrophilic Peroxisome Proliferator–Activated Receptor-γ Ligands Have Potent Antifibrotic Effects in Human Lung Fibroblasts

(2009) Heather E. Ferguson et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

The nuclear signaling of NF-κB: current knowledge, new insights and future perspectives

(2009) Fengyi Wan et al.   CELL RESEARCH

Regulation of myofibroblast differentiation by convergence of the Wnt and TGF-β1/Smad signaling pathways

(2009) Sarah Jane George   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY