Trojan horses and guided missiles: targeted therapies in the war on arthritis

Hyaluronate–Gold Nanoparticle/Tocilizumab Complex for the Treatment of Rheumatoid Arthritis

(2014) Hwiwon Lee et al.   ACS Nano

Fumagillin Prodrug Nanotherapy Suppresses Macrophage Inflammatory Response via Endothelial Nitric Oxide

(2014) Hui-fang Zhou et al.   ACS Nano

A hyaluronic acid–methotrexate conjugate for targeted therapy of rheumatoid arthritis

(2014) Jung Min Shin et al.   CHEMICAL COMMUNICATIONS

Targeting fibroblast-like synovial cells at sites of inflammation with peptide targeted liposomes results in inhibition of experimental arthritis

(2014) A.S. Vanniasinghe et al.   CLINICAL IMMUNOLOGY

A novel bispecific antibody targeting tumor necrosis factor α and ED-B fibronectin effectively inhibits the progression of established collagen-induce arthritis

(2014) Mengyuan Liu et al.   JOURNAL OF BIOTECHNOLOGY

Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis

(2014) Hui-fang Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Hyaluronan nanoparticles bearing γ-secretase inhibitor: In vivo therapeutic effects on rheumatoid arthritis

(2014) Roun Heo et al.   JOURNAL OF CONTROLLED RELEASE

A hyaluronic acid–salmon calcitonin conjugate for the local treatment of osteoarthritis: Chondro-protective effect in a rabbit model of early OA

(2014) Anna Mero et al.   JOURNAL OF CONTROLLED RELEASE

Antibody-based delivery of IL4 to the neovasculature cures mice with arthritis

(2014) T. Hemmerle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting of viral interleukin-10 with an antibody fragment specific to damaged arthritic cartilage improves its therapeutic potency

(2014) Chris Hughes et al.   ARTHRITIS RESEARCH & THERAPY

Nanomedicines for Inflammatory Arthritis: Head-to-Head Comparison of Glucocorticoid-Containing Polymers, Micelles, and Liposomes

(2013) Lingdong Quan et al.   ACS Nano

Mechanisms of Nanoparticle-Mediated siRNA Transfection by Melittin-Derived Peptides

(2013) Kirk K. Hou et al.   ACS Nano

New learnings on the pathophysiology of RA from synovial biopsies

(2013) Costantino Pitzalis et al.   CURRENT OPINION IN RHEUMATOLOGY

HSA nanocapsules functionalized with monoclonal antibodies for targeted drug delivery

(2013) Alexandra Rollett et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Temperature-modulated noncovalent interaction controllable complex for the long-term delivery of etanercept to treat rheumatoid arthritis

(2013) Young-Seok Jung et al.   JOURNAL OF CONTROLLED RELEASE

An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis

(2013) Sinéad M. Ryan et al.   JOURNAL OF CONTROLLED RELEASE

TNF-α Gene Silencing Using Polymerized siRNA/Thiolated Glycol Chitosan Nanoparticles for Rheumatoid Arthritis

(2013) So Jin Lee et al.   MOLECULAR THERAPY

Emerging cell and cytokine targets in rheumatoid arthritis

(2013) Gerd R. Burmester et al.   Nature Reviews Rheumatology

Systemic Delivery of Small Interfering RNA Targeting the Interleukin-2/15 Receptor β Chain Prevents Disease Progression in Experimental Arthritis

(2013) Tiantian Zhang et al.   PLoS One

Murine analogues of etanercept and of F8-IL10 inhibit the progression of collagen-induced arthritis in the mouse

(2013) Fabia Doll et al.   ARTHRITIS RESEARCH & THERAPY

Targeted Chemo-Photothermal Treatments of Rheumatoid Arthritis Using Gold Half-Shell Multifunctional Nanoparticles

(2012) Sun-Mi Lee et al.   ACS Nano

The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

(2012) Hiroshi Maeda et al.   ADVANCED DRUG DELIVERY REVIEWS

Targeted delivery of cytokine therapy to rheumatoid tissue by a synovial targeting peptide

(2012) Sarah E Wythe et al.   ANNALS OF THE RHEUMATIC DISEASES

Treatment of experimental arthritis by targeting synovial endothelium with a neutralizing recombinant antibody to C5

(2012) Paolo Macor et al.   ARTHRITIS AND RHEUMATISM

Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis

(2012) Palanisamy Kanakaraj et al.   mAbs

Cell-penetrating peptides released from thermosensitive nanoparticles suppress pro-inflammatory cytokine response by specifically targeting inflamed cartilage explants

(2012) Rush L. Bartlett et al.   Nanomedicine-Nanotechnology Biology and Medicine

Hypoxia—a key regulator of angiogenesis and inflammation in rheumatoid arthritis

(2012) Sofia Konisti et al.   Nature Reviews Rheumatology

Gene expression profiling and functional analysis of angiogenic markers in murine collagen-induced arthritis

(2012) Yvonne Raatz et al.   ARTHRITIS RESEARCH & THERAPY

Polymers and Drug Delivery Systems

(2012) Gemma Vilar et al.   Current Drug Delivery

Suppression of neovascularization and experimental arthritis by D-form of anti-flt-1 peptide conjugated with mini-PEG™

(2011) Jin-Sun Kong et al.   ANGIOGENESIS

Designing micro- and nano-particles for treating rheumatoid arthritis

(2011) Samir Mitragotri et al.   ARCHIVES OF PHARMACAL RESEARCH

Development of a novel recombinant biotherapeutic with applications in targeted therapy of human arthritis

(2011) Panagiotis Kamperidis et al.   ARTHRITIS AND RHEUMATISM

Folate-targeted nanoparticles show efficacy in the treatment of inflammatory arthritis

(2011) Thommey P. Thomas et al.   ARTHRITIS AND RHEUMATISM

Polymer–drug conjugates as nano-sized medicines

(2011) Fabiana Canal et al.   CURRENT OPINION IN BIOTECHNOLOGY

Efficacy and Tolerability of Pegloticase for the Treatment of Chronic Gout in Patients Refractory to Conventional Treatment

(2011)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

State of the art in PEGylation: The great versatility achieved after forty years of research

(2011) Gianfranco Pasut et al.   JOURNAL OF CONTROLLED RELEASE

Functionalized STAT1 siRNA nanoparticles regress rheumatoid arthritis in a mouse model

(2011) Robert I Scheinman et al.   Nanomedicine

Peptides targeting inflamed synovial vasculature attenuate autoimmune arthritis

(2011) Y.-H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

State-of-the-art: rheumatoid arthritis

(2010) I. B. McInnes et al.   ANNALS OF THE RHEUMATIC DISEASES

Current evidence for the management of rheumatoid arthritis with biological disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of RA

(2010) J. L. Nam et al.   ANNALS OF THE RHEUMATIC DISEASES

Syntheses of Click PEG−Dexamethasone Conjugates for the Treatment of Rheumatoid Arthritis

(2010) Xin-Ming Liu et al.   BIOMACROMOLECULES

Ionic complex systems based on hyaluronic acid and PEGylated TNF-related apoptosis-inducing ligand for treatment of rheumatoid arthritis

(2010) Yu-Jeong Kim et al.   BIOMATERIALS

The vasculature in rheumatoid arthritis: cause or consequence?

(2010) Ewa M. Paleolog   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Certolizumab Pegol

(2010) Niti Goel et al.   mAbs

Pharmacokinetic and Biodistribution Studies ofN-(2-Hydroxypropyl)methacrylamide Copolymer-Dexamethasone Conjugates in Adjuvant-Induced Arthritis Rat Model

(2010) Ling-dong Quan et al.   MOLECULAR PHARMACEUTICS

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy

(2010) Ling-dong Quan et al.   ARTHRITIS RESEARCH & THERAPY

Folate receptor β as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients

(2009) Joost W. Van Der Heijden et al.   ARTHRITIS AND RHEUMATISM

Use of biofluorescence imaging to compare the distribution of certolizumab pegol, adalimumab, and infliximab in the inflamed paws of mice with collagen-induced arthritis

(2009) Roger Palframan et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis

(2009) Peter C. Taylor et al.   Nature Reviews Rheumatology

Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis

(2009) Kathrin Schwager et al.   ARTHRITIS RESEARCH & THERAPY

Reduction of plasma urate levels following treatment with multiple doses of pegloticase (polyethylene glycol-conjugated uricase) in patients with treatment-failure gout: Results of a phase II randomized study

(2008) John S. Sundy et al.   ARTHRITIS AND RHEUMATISM

The Potential of Liposomal Drug Delivery for the Treatment of Inflammatory Arthritis

(2008) Anne S. Vanniasinghe et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Discovery and Development of Folic-Acid-Based Receptor Targeting for Imaging and Therapy of Cancer and Inflammatory Diseases

(2007) Philip S. Low et al.   ACCOUNTS OF CHEMICAL RESEARCH