Article
Immunology
Ran Wang, Jing Liu, Zhehuan Wang, Xiaohan Wu, Hui Guo, Xiangyue Jiao, Huiru Zhang, Caihong Qi, Xiaotian Li
Summary: The study demonstrated that mangiferin effectively alleviates arthritis symptoms, reduces inflammatory cytokine secretion, inhibits synovial inflammation, and slows down bone erosion in arthritic rats. It achieves these effects by modulating oxidative stress levels and reducing inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ekta Singh, Riyaz Ali M. Osmani, Rinti Banerjee, Amr Selim Abu Lila, Afrasim Moin, Khaled Almansour, Hany H. Arab, Hadil Faris Alotaibi, El-Sayed Khafagy
Summary: This study developed leflunomide-loaded nanoparticles as a local drug delivery system for the treatment of rheumatoid arthritis. The nanoparticles showed sustained drug release in simulated synovial fluid and demonstrated efficacy in reducing inflammation and immune responses without notable toxicity in animal models. These findings suggest that intra-articularly administered leflunomide nanoparticles could be a potential alternative to systemic drugs for the treatment of rheumatoid arthritis.
Article
Pharmacology & Pharmacy
Edward Weaver, Edward O'Connor, David K. Cole, Andrew Hooker, Shahid Uddin, Dimitrios A. Lamprou
Summary: The encapsulation of biologic molecules using a microfluidic platform shows great promise for the manufacturing of protein loaded lipid nanoparticles. This study investigates the encapsulation of bovine serum albumin (BSA) and trypsin using various phospholipids, and demonstrates the eligibility of the system to other biological medications. The results indicate that liposomes containing 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) show good stability and improved loading capacity for BSA compared to conventional methods, while maintaining controlled release of the active pharmaceutical ingredient.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Maria Jose Alcaraz
Summary: Synovial cells, especially activated synovial fibroblasts, are key players in joint destruction in rheumatoid arthritis. Identifying SF phenotypes, controlling epigenetic changes, and modulating cellular functions are promising approaches to develop novel therapeutic targets for preserving joint architecture and function in RA. Further research is needed to determine the most relevant targets for drug development.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chuyu Shen, Meilin Xu, Siqi Xu, Shuoyang Zhang, Wei Lin, Hao Li, Shan Zeng, Qian Qiu, Liuqin Liang, Youjun Xiao, Hanshi Xu
Summary: This study investigated the role and mechanism of Myricitrin (Myr) in regulating synovitis and joint destruction mediated by fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). The results showed that Myr treatment inhibited the migration and invasion of RA FLS, reduced the expression of inflammatory cytokines and MMPs, and suppressed the phosphorylation of AKT. Furthermore, Myr administration relieved arthritis symptoms in a mouse model of collagen-induced arthritis (CIA).
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yayun Xu, Zhuoyan Zai, Zheng Lu, Tao Zhang, Longfei Wang, Xuewen Qian, Jingjing Tao, Xiaoqing Peng, Yihao Zhang, Feihu Chen
Summary: The circCDKN2B-AS_006/miR-1258/RUNX1 axis plays a crucial role in promoting the tumor-like growth and metastasis of RASFs in rheumatoid arthritis. Inhibition of circCDKN2B-AS_006 expression alleviates arthritis severity and inhibits aggressive behaviors of RASFs in a mouse model. This study highlights the importance of circRNAs in the pathogenesis of RA and provides a potential therapeutic target for its treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Mei Meng, Zhenggang Yue, Lu Chang, Yanru Liu, Jinhang Hu, Zhongxing Song, Zhishu Tang, Rui Zhou, Changli Wang
Summary: PS VII inhibits the proliferation and induces apoptosis of RA-FLS and MH7A cells by regulating the mitochondrial apoptotic pathway and the JNK and p38 MAPK pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Junnan Zhou, Yuhang Mao, Xiaotian Shi, Yudie Zhang, Xiaolu Yu, Xuan Liu, Li Diao, Xue Yang, Changze Liu, Dan Liu, Xin Tan, Mei Liu
Summary: This study demonstrates the potential therapeutic effect of peimine on rheumatoid arthritis (RA), including the inhibition of destructive behaviors and over-expression of pro-inflammatory cytokines. It also provides insights into the molecular mechanism of action of peimine on RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Naoki Iwamoto, Kaori Furukawa, Yushiro Endo, Toshimasa Shimizu, Remi Sumiyoshi, Masataka Umeda, Tomohiro Koga, Shin-ya Kawashiri, Takashi Igawa, Kunihiro Ichinose, Mami Tamai, Tomoki Origuchi, Atsushi Kawakami
Summary: The study revealed that MTX treatment altered the expression of 13 miRNAs, with miR-877-3p being upregulated. MiR-877-3p was found to reduce the production of GM-CSF and CCL3 in RA-FLS, as well as inhibit their migratory and proliferative activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Chuyu Shen, Yu Kuang, Shudi Xu, Ruiru Li, Jingnan Wang, Yaoyao Zou, Cuicui Wang, Siqi Xu, Liuqin Liang, Changsong Lin, Youjun Xiao, Hanshi Xu
Summary: Nitidine chloride (NC) inhibits the invasive and inflammatory actions of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) by targeting KCNH1 gene and inhibiting AKT phosphorylation, reducing the severity of arthritis in mice with RA. This discovery suggests that NC may be a novel therapeutic agent for RA, controlling FLS-mediated rheumatoid synovial inflammation and joint destruction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yitong Tong, Xinyu Li, Qichuan Deng, Jianyou Shi, Yibin Feng, Lan Bai
Summary: Rheumatoid arthritis (RA) is a chronic autoimmune and inflammatory disease characterized by altered fibroblast-like synoviocyte (FLS) function. Targeting the pathological role of FLS is a promising approach for new anti-RA drugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Gehad A. Abdel Jaleel, Samar S. Azab, Wesam M. el-Bakly, Azza Hassan
Summary: Methyl palmitate exhibits significant anti-inflammatory effects in a rat model of adjuvant-induced arthritis, reducing arthritic symptoms and inflammatory markers. Its potential therapeutic benefits in rheumatoid arthritis are supported by its ability to inhibit synovial CD68 macrophage expression.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Olivia Amanda Oest Mullertz, Peter Andersen, Dennis Christensen, Camilla Foged, Aneesh Thakur
Summary: The mucosal surfaces of the lungs are a major site for entry of airborne pathogens and pulmonary vaccination can induce protective mucosal immunity. Researchers found that altering the surface charge of liposomes can enhance specific T-cell responses, but the impact on mucosal immunity remains unclear.
MOLECULAR PHARMACEUTICS
(2022)
Article
Oncology
Jenifer Garcia-Fernandez, Maria de la Fuente Freire
Summary: This article introduces the characteristics of exosomes and their application in the field of biomedical research. However, there are still limitations in manufacturing processes, quality control, and clinical studies. In recent years, exosome-like systems based on surface engineering and nanoscale platforms have been developed to overcome these limitations. By combining the latest knowledge of exosome research with promising developments in nanotechnology, innovative targeted anti-cancer therapies can be developed. This article provides a critical overview of the design and testing of innovative exosome-like systems and discusses the most promising modalities that can be translated into the clinic, as well as future perspectives and challenges in this field.
Article
Pharmacology & Pharmacy
Tianyue Zhang, Xu Ouyang, Sanhu Gou, Yun Zhang, Na Yan, Linlin Chang, Beibei Li, Fangyan Zhang, Hui Liu, Jingman Ni
Summary: In this study, two peptide-drug conjugates (PDCs) were synthesized by connecting Sinomenine (SIN) with a synovial homing peptide. The cyclic conjugate (C) showed better stability in serum and inflammatory joints, leading to improved therapeutic efficacy and tissue targeting.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Orthopedics
T. Meade, E. Dowswell, N. Manolios, L. Sharpe
BMC MUSCULOSKELETAL DISORDERS
(2015)
Article
Oncology
Matthew M. K. Chan, Richard F. Kefford, Matteo Carlino, Arthur Clements, Nicholas Manoliosz
JOURNAL OF IMMUNOTHERAPY
(2015)
Article
Dermatology
Marina Ali, Rachael Anforth, Flavia Senetiner, Giuliana Carlos, Pablo Fernandez-Penas
EXPERIMENTAL DERMATOLOGY
(2016)
Article
Rheumatology
David J. Tunnicliffe, Davinder Singh-Grewal, Jeffrey Chaitow, Fiona Mackie, Nicholas Manolios, Ming-Wei Lin, Sean G. O'Neill, Angelique F. Ralph, Jonathan C. Craig, Allison Tong
ARTHRITIS CARE & RESEARCH
(2016)
Review
Rheumatology
Nicola Barrie, Vindhya Kuruppu, Emmanuel Manolios, Marina Ali, Minoo Moghaddam, Nicholas Manolios
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2017)
Review
Rheumatology
Tanya Meade, Nicholas Manolios, Steven R. Cumming, Philip G. Conaghan, Patricia Katz
ARTHRITIS CARE & RESEARCH
(2018)
Article
Immunology
Marina Ali, Michael Amon, Vera Bender, Andrea Bolte, Frances Separovic, Heather Benson, Nicholas Manolios
CLINICAL IMMUNOLOGY
(2014)
Article
Endocrinology & Metabolism
M. S. Wong, A. Tso, M. Ali, W. J. Hawthorne, N. Manolios
DIABETES & METABOLISM
(2014)
Article
Radiology, Nuclear Medicine & Medical Imaging
Socrates Angelides, Manal El-Mashaleh, Marienne Anagnostou, Graydon Howe, David Spencer, Vijay Kumar, Nicholas Manolios
NUCLEAR MEDICINE COMMUNICATIONS
(2014)
Article
Biochemistry & Molecular Biology
Nicholas Manolios, Son Pham, Guojiang Hou, Jonathan Du, Camelia Quek, David Hibbs
Summary: T-cell recognition of antigens leads to immune responses that involve complex biochemical and cellular events. This includes the production of cytokines that regulate T-cell functions and facilitate the elimination of antigens. Our study used in silico docking and in vitro assays to show that targeting the T-cell C beta-FG loop can alter T-cell signaling independently of antigens. This novel approach warrants further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Ali Azimi, Kimberley L. Kaufman, Marina Ali, Steven Kossard, Pablo Fernandez-Penas
CANCER GENOMICS & PROTEOMICS
(2016)
Article
Rheumatology
Nicholas Manolios, Marina Ali, Bradley Camden, Elham Aflaky, Katrina Pavic, Andrew Markewycz, Robert De Costa, Socrates Angelides
EUROPEAN JOURNAL OF RHEUMATOLOGY
(2016)
Article
Medicine, Research & Experimental
Afshin Samiei, Ali Mohammad Tamadon, Soliman Mohammadi Samani, Nicholas Manolios, Eskandar Kamali Sarvestani
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2014)