Recurrent DNA damage is associated with persistent injury in progressive radiation-induced pulmonary fibrosis

Radiation induced pulmonary fibrosis as a model of progressive fibrosis: Contributions of DNA damage, inflammatory response and cellular senescence genes

(2017) Tyler A. Beach et al.   EXPERIMENTAL LUNG RESEARCH

Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice

(2017) Jin Pan et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Radiation-induced unrepairable DSBs: their role in the late effects of radiation and possible applications to biodosimetry

(2017) Asao Noda   JOURNAL OF RADIATION RESEARCH

A Single Exposure to Low- or High-LET Radiation Induces Persistent Genomic Damage in Mouse Epithelial Cells In Vitro and in Lung Tissue

(2017) Erica Werner et al.   RADIATION RESEARCH

Gamma-irradiated quiescent cells repair directly induced double-strand breaks but accumulate persistent double-strand breaks during subsequent DNA replication

(2016) Yusuke Minakawa et al.   GENES TO CELLS

Truncated Plasminogen Activator Inhibitor-1 Protein Protects From Pulmonary Fibrosis Mediated by Irradiation in a Murine Model

(2016) Eun Joo Chung et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Addressing the Symptoms or Fixing the Problem? Developing Countermeasures against Normal Tissue Radiation Injury

(2016) Jacqueline P. Williams et al.   RADIATION RESEARCH

Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues

(2016) EA Georgakopoulou et al.   Aging-US

DNA damage foci: Meaning and significance

(2015) Kai Rothkamm et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

DNA damage at respiratory distress, but not acute time-points, correlates with tissue fibrosis following thoracic radiation exposure in mice

(2015) Amit Kunwar et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Acute adaptive immune response correlates with late radiation-induced pulmonary fibrosis in mice

(2015) Alexandra Paun et al.   Radiation Oncology

Role of Pro-inflammatory Cytokines in Radiation-Induced Genomic Instability in Human Bronchial Epithelial Cells

(2015) Erica Werner et al.   RADIATION RESEARCH

Whole-Lung Irradiation Results in Pulmonary Macrophage Alterations that are Subpopulation and Strain Specific

(2015) Angela M. Groves et al.   RADIATION RESEARCH

Dose Optimization Study of AEOL 10150 as a Mitigator of Radiation-Induced Lung Injury in CBA/J Mice

(2015) Francis N. Murigi et al.   RADIATION RESEARCH

Cellular senescence and its effector programs

(2014) R. Salama et al.   GENES & DEVELOPMENT

Targeting the Renin–Angiotensin System Combined With an Antioxidant Is Highly Effective in Mitigating Radiation-Induced Lung Damage

(2014) Javed Mahmood et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Opposite Roles for p38MAPK-Driven Responses and Reactive Oxygen Species in the Persistence and Resolution of Radiation-Induced Genomic Instability

(2014) Erica Werner et al.   PLoS One

Transforming Growth Factor Alpha is a Critical Mediator of Radiation Lung Injury

(2014) Eun Joo Chung et al.   RADIATION RESEARCH

Even low doses of radiation lead to DNA damage accumulation in lung tissue according to the genetically-defined DNA repair capacity

(2014) Elias Flockerzi et al.   RADIOTHERAPY AND ONCOLOGY

Molecular Basis of Asbestos-Induced Lung Disease

(2013) Gang Liu et al.   Annual Review of Pathology-Mechanisms of Disease

Senescence-associated secretory phenotype in a mouse model of bleomycin-induced lung injury

(2013) Kazutetsu Aoshiba et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Role of Type II Pneumocyte Senescence in Radiation-Induced Lung Fibrosis

(2013) Deborah E. Citrin et al.   JNCI-Journal of the National Cancer Institute

Prolonged expression of senescence markers in mice exposed to gamma-irradiation

(2013) Min-A Seol et al.   Journal of Veterinary Science

Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema

(2013) Marco Chilosi et al.   Translational Research

Oxidative stress and pulmonary fibrosis

(2012) Paul Cheresh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Discordance between phosphorylation and recruitment of 53BP1 in response to DNA double-strand breaks

(2012) Shane M. Harding et al.   CELL CYCLE

A Preclinical Rodent Model of Radiation-induced Lung Injury for Medical Countermeasure Screening in Accordance With the FDA Animal Rule

(2012) Isabel L. Jackson et al.   HEALTH PHYSICS

Oxidative Stress Mediates Radiation Lung Injury by Inducing Apoptosis

(2012) Yu Zhang et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

Non-targeted effects of ionising radiation—Implications for low dose risk

(2012) Munira Kadhim et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Differential analysis of gene regulation at transcript resolution with RNA-seq

(2012) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Mitigation of Radiation-Induced Lung Injury with EUK-207 and Genistein: Effects in Adolescent Rats

(2012) J. Mahmood et al.   RADIATION RESEARCH

RNA-Seq analysis in MeV

(2011) E. A. Howe et al.   BIOINFORMATICS

Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury

(2011) Edouard I. Azzam et al.   CANCER LETTERS

Prolonged expression of the γ-H2AX DNA repair biomarker correlates with excess acute and chronic toxicity from radiotherapy treatment

(2011) Emma C. Bourton et al.   INTERNATIONAL JOURNAL OF CANCER

Role of oxidative stress and DNA damage in human carcinogenesis

(2011) Thomas B. Kryston et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

ATM-dependent phosphorylation of 53BP1 in response to genomic stress in oxic and hypoxic cells

(2011) Shane M. Harding et al.   RADIOTHERAPY AND ONCOLOGY

Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status

(2010) Oanh N. L. Le et al.   AGING CELL

Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells

(2010) Shunsuke Minagawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis

(2010) Corrine R. Kliment et al.   FREE RADICAL BIOLOGY AND MEDICINE

Animal Models for Medical Countermeasures to Radiation Exposure

(2010) Jacqueline P. Williams et al.   RADIATION RESEARCH

Radiation Pulmonary Toxicity: From Mechanisms to Management

(2010) Paul R. Graves et al.   SEMINARS IN RADIATION ONCOLOGY

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Oxidative stress and glutathione in TGF-β-mediated fibrogenesis

(2009) R.-M. Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Late Residual γ-H2AX Foci In Murine Skin are Dose Responsive and Predict RadiosensitivityIn Vivo

(2009) Nirmal Bhogal et al.   RADIATION RESEARCH

Inflammation and Chronic Oxidative Stress in Radiation-Induced Late Normal Tissue Injury: Therapeutic Implications

(2008) Weiling Zhao et al.   CURRENT MEDICINAL CHEMISTRY

Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence

(2003) Utz Herbig et al.   AGING CELL