Article
Environmental Sciences
Wanchang Cui, Pei Zhang, Kim G. Hankey, Mang Xiao, Ann M. Farese, Thomas J. MacVittie
Summary: This study on radiation-induced lung injury in a non-human primate model found that oxidative stress and inflammatory cell infiltration play a key role in the damage, and treatment with an oxidative stress scavenger can significantly reduce this injury.
Article
Pharmacology & Pharmacy
Meetha Medhora, Preeya Phadnis, Jayashree Narayanan, Tracy Gasperetti, Jacek Zielonka, John E. Moulder, Brian L. Fish, Aniko Szabo
Summary: There are currently no FDA-approved drugs for mitigating the delayed effects of radiation exposure. Angiotensin-converting enzyme inhibitors have shown potential in mitigating radiation injuries in rodent models. The study compared the pharmacokinetics of the ACE inhibitor lisinopril in irradiated and nonirradiated rats.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Xiao Lei, Lehui Du, Wei Yu, Yao Wang, Na Ma, Baolin Qu
Summary: GSTP1, an isoenzyme in the glutathione-S transferases enzyme system, is closely associated with the risk of radiation induced lung injury (RILI) development. It may play a role in RILI by regulating cell oxidative stress, inhibiting cell apoptosis, and promoting cytotoxic metabolism.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Immunology
Zengfu Zhang, Jialin Zhou, Vivek Verma, Xu Liu, Meng Wu, Jinming Yu, Dawei Chen
Summary: Radiation-induced lung injury (RILI) and immunotherapy-related lung injury (IRLI) are two common complications in cancer treatment, with potential downstream pathway of pyroptosis identified as a crucial signaling pathway in lung injury treatment. More research is needed to fully understand the underlying mechanisms and signaling pathways of these complications to explore potential therapeutic targets and avenues for further research.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhaslan Abishev, Bakhyt Ruslanova, Saulesh Apbassova, Nailya Chaizhunussova, Dariya Shabdarbayeva, Almas Azimkhanov, Kassym Zhumadilov, Valeriy Stepanenko, Sergey Ivanov, Peter Shegay, Masaharu Hoshi, Nariaki Fujimoto
Summary: The investigation focused on the radiation effects of residual radioactive dust from the atomic bombings in Hiroshima and Nagasaki. When studying the effects of manganese dioxide-56 ((MnO2)-Mn-56) on Wistar rats, significant changes were observed in the lungs. To further examine the effects of (MnO2)-Mn-56 in a different species, male C57BL mice were exposed to (MnO2)-Mn-56, stable MnO2 particles, or external gamma-rays.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sahebgowda Sidramagowda Patil, Helena Hernandez-Cueryo, Jutaro Fukumoto, Sudarshan Krishnamurthy, Muling Lin, Matthew Alleyn, Mason Breitzig, Venkata Ramireddy Narala, Ramani Soundararajan, Richard F. Lockey, Narasaiah Kolliputi, Lakshmi Galam
Summary: Acute lung injury (ALI) is a leading cause of mortality in older adults, and oxygen therapy is a common treatment method. Alda-1 protects against oxidative stress by enhancing ALDH2 activity, and also shows protective effects against ischemic reperfusion injury, heart failure, and other conditions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wanli Jiang, Chengtai Ma, Jiawei Bai, Xianjin Du
Summary: This study investigates the role and mechanism of macrophage SAMSN1 in sepsis-induced acute lung injury (ALI). The results demonstrate that macrophage SAMSN1 overexpression can protect against sepsis-induced inflammation, oxidative stress, and ALI by activating AMPKα2 through the GAB1/SHP2/PKA pathway.
Article
Environmental Sciences
Rui Xiong, Wenyang Jiang, Ning Li, Bohao Liu, Ruyuan He, Bo Wang, Qing Geng
Summary: The study found that exposure to PM2.5 can increase inflammatory response, oxidative stress, and apoptosis levels in lung tissue. Knockout of macrophage-specific NLRP3 gene can mitigate these effects.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pharmacology & Pharmacy
Qingwen Yuan, Renjun Peng, Huijie Yu, Sinian Wang, Zhongmin Chen, Suhe Dong, Wei Li, Bo Cheng, Qisheng Jiang, Yuwen Cong, Fengsheng Li, Changzheng Li
Summary: The study demonstrates that disulfiram, an FDA-approved alcohol deterrent, shows radioprotective efficacy by affecting the cell cycle and regulating the DNA damage response and survival of intestinal stem cells. It could be a promising candidate for preventing radiation-induced intestinal injury (RIII) in cancer therapy and nuclear accidents.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mohamed El-Sherbiny, Hoda Atef, Mohamed Ahmed Eladl, Abdelaty Shawky Mohamed, Mohamed El-Shafey, Howaida S. Ali, Sawsan A. Zaitone, Suliman Y. Alomar, Saeed Awad M. Alqahtani, Sheka Yagub Aloyouni, Mohammed A. Attia
Summary: The study revealed that leflunomide induces dose-dependent pulmonary injury, with higher doses leading to increased expression of pathological markers and causing distorted lung architecture, inflammatory cell infiltration, and elevated collagen content. Further investigation is needed to understand the nature of this pulmonary toxicity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Vidya P. Kumar, Shukla Biswas, Gregory P. Holmes-Hampton, Torsten Goesch, William Fahl, Sanchita P. Ghosh
Summary: PrC-210, when administered orally, can effectively protect mice from radiation-induced hematopoietic and intestinal injury by accelerating recovery, reducing oxidative stress, and decreasing mortality.
Article
Biochemistry & Molecular Biology
Sohi Kang, Hae-June Lee, Yeonghoon Son, Min Ji Bae, Wol Soon Jo, Jun Hong Park, Sohee Jeong, Changjong Moon, In-Sik Shin, Chang Geun Lee, Joong Sun Kim
Summary: The study investigates the synergistic effects of radiation damage and environmental pollution on cells or tissues. By exposing mice to low-dose-rate radiation and titanium dioxide nanoparticles (TiO2NPs), it was found that the combination of the two stimuli significantly increased pulmonary inflammation through MAPK phosphorylation. This highlights the need to consider the potential combined effects of low-dose radiation and TiO2NPs in patients with respiratory problems.
MOLECULAR & CELLULAR TOXICOLOGY
(2023)
Article
Oncology
Weronika Maria Szejniuk, Martin Skovmos Nielsen, Zsuzsanna Takacs-Szabo, Jacek Pawlowski, Sahar Sulaiman Al-Saadi, Panagiotis Maidas, Martin Bogsted, Tine McCulloch, Jens Brondum Frokjaer, Ursula Gerda Falkmer, Oluf Dimitri Roe
Summary: This study aimed to evaluate the utility of a novel radiation-induced lung injury (RILI) grading scale (RGS) for predicting radiation pneumonitis (RP) after thoracic radiation therapy. Results showed that patients with RGS grades 2-3 had a significantly higher risk for developing RP, and RGS demonstrated good specificity in predicting symptomatic RP.
RADIATION ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiaoxia Kong, Liling Lu, Daopeng Lin, Lei Chong, Shunhang Wen, Yaokai Shi, Lidan Lin, Liqin Zhou, Hongyu Zhang, Hailin Zhang
Summary: This study found that FGF10 has a protective effect on acute lung injury. FGF10 can prevent the release of IL-6, TNF-alpha, and IL-1 beta, activate the autophagy pathway, and promote the regeneration of alveolar epithelial cells. The BMP4 signaling pathway plays an important role in the protective effect of FGF10.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Zhiqi Xie, Haoyang Zhou, Masanori Obana, Yasushi Fujio, Naoki Okada, Masashi Tachibana
Summary: Viral pneumonia is a global health burden, particularly for the elderly and patients with underlying diseases. Recent studies have shown that myeloid-derived suppressor cells (MDSCs) are abundant in these patients, but their role in the progression of viral pneumonia is still unclear. This study found a significant increase in MDSCs in a mouse model and in older mice. When polyinosinic-polycytidylic acid (poly(I:C)) was used to mimic viral pneumonia, mice with renal ischemia/reperfusion (I/R) injury had more severe lung inflammation compared to control mice. Additionally, depleting MDSCs attenuated lung inflammation in mice with I/R injury. Similar results were observed in older mice compared to young mice. Furthermore, transferring in vitro-differentiated MDSCs worsened poly(I:C)-induced lung inflammation. These findings suggest that the increased proportion of MDSCs in mice with renal I/R injury and in older mice exacerbates poly(I:C)-induced lung inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Aurelien Jongen, Florian Charlier, Kelsey Baker, John Chang, William Hartsell, George Laramore, Pranshu Mohindra, Luigi Moretti, Mary Redman, Lane Rosen, Henry Tsai, Dirk Van Gestel, Carlos Vargas, Ramesh Rengan
Summary: This study reported the clinical outcomes of patients with locally advanced non-small cell lung cancer treated with PBT, showing low rates of adverse events and similar survival rates to other studies. Good performance status, pencil beam scanning use, and increased EQD2 were associated with decreased mortality.
ADVANCES IN RADIATION ONCOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Patrizia Guerrieri, Naduparambil K. Jacob, Peter G. Maxim, Amit Sawant, Samantha J. Van Nest, Pranshu Mohindra, Michael M. Dominello, Jay W. Burmeister, Michael C. Joiner
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Article
Oncology
Bradford S. Hoppe, Romaine C. Nichols, Stella Flampouri, Mark Pankuch, Christopher G. Morris, Dat C. Pham, Pranshu Mohindra, William F. Hartsell, Nasiruddin Mohammed, Brian H. Chon, Larry L. Kestin, Charles B. Simone, Charles B. Simone
Summary: This study aimed to evaluate the impact of hypofractionated proton therapy with concurrent chemotherapy on overall survival in patients with locally advanced non-small cell lung cancer. The results showed promising survival rates at 1-year and 3-year follow-up, with minimal toxic effects.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Esther M. Vicente, Arezoo Modiri, John Kipritidis, Kun-Chang Yu, Kai Sun, Jochen Cammin, Arun Gopal, Jingzhu Xu, Sina Mossahebi, Aaron Hagan, Yulong Yan, Daniel Rockwell Owen, Pranshu Mohindra, Martha M. Matuszak, Robert D. Timmerman, Amit Sawant
Summary: Functional lung avoidance (FLA) radiation therapy and functionally weighted airway sparing (FWAS) method show good performance in reducing post-RT pulmonary toxicity. Combining these two approaches can further enhance lung function protection for patients.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Dahlia Kronfli, Akilah Lievers, Kaysee Baker, Caitlin Eggleston, Robert Miller, Soren M. Bentzen, Pranshu Mohindra, Melissa A. L. Vyfhuis
Summary: This study analyzed the psychosocial needs of cancer patients undergoing radiation therapy using a questionnaire. The study found that Black patients had different characteristics compared to non-Black patients in terms of marital status, income, and treatment location. Additionally, Black patients had higher rates of unmet needs regarding pain, stress management, transportation, and smoking cessation.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Review
Oncology
Chirayu G. Patel, Jennifer Peterson, Marianne Aznar, Yolanda D. Tseng, Scott Lester, Deanna Pafundi, Stella Flampouri, Pranshu Mohindra, Rahul R. Parikh, Raymond Mailhot Vega, Laila Konig, John P. Plastaras, James E. Bates, Pierre Loap, Youlia M. Kirova, Ester Orlandi, Carola Luetgendorf-Caucig, Georgios Ntentas, Bradford Hoppe
Summary: This study systematically reviewed dosimetric studies comparing deep inspiration breath hold (DIBH) with free breathing (FB) in mediastinal lymphoma patients undergoing proton therapy, and found that proton therapy (FB or DIBH) was superior to IMRT-DIBH in reducing doses to the heart, lungs, and breast.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Ariel E. Pollock, Hunter Risher, Melanie Berger, Dana M. Roque, Gautam Rao, Elizabeth M. Nichols, Pranshu Mohindra
Summary: This study aimed to evaluate the oncologic and toxicity outcomes of using intensity modulated proton therapy (IMPT) for pelvic/abdominal reirradiation (re-RT) in patients with gynecologic cancers. The results demonstrated excellent local control and acceptable acute and late toxicity for re-RT with IMPT in gynecologic malignancies.
ADVANCES IN RADIATION ONCOLOGY
(2023)
Meeting Abstract
Oncology
B. Savla, M. A. Hamza, K. Markan, D. Yacubovich, S. Cobbs, L. Petrovska, K. Scilla, W. Burrows, R. Mehra, R. C. Miller, C. Rolfo, P. Mohindra, M. A. L. Vyfhuis
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Meeting Abstract
Oncology
U. Markan, C. DeCesaris, E. M. Nichols, S. A. McAvoy, S. Ruff, S. Cheston, P. Mohindra, P. Oswald, M. A. L. Vyfhuis
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Meeting Abstract
Oncology
A. Modiri, S. Koduri, B. Savla, A. Ahmady, J. Marter, E. M. Vicente, A. Sawant, J. Jeudy, P. Mohindra
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Meeting Abstract
Oncology
E. Kaya, A. L. Oliver, R. J. Thomas, S. E. Beltran Ponce, I. I. Franco, G. Vidal, A. R. Chaurasia, D. A. Diaz Pardo, C. H. Chapman, J. M. Longo, S. Patel, R. Mailhot Vega, P. Mohindra, R. Diaz, C. R. Thomas, C. Deville, M. D. Mattes
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Meeting Abstract
Oncology
C. D. Rolfo, D. De Miguel Perez, U. Mallapelle, W. Grier, F. Pepe, G. Troncone, M. Culligan, K. A. Scilla, R. Mehra, A. Russo, P. Mohindra, A. Sachdeva, F. R. Hirsch, A. Wolf, J. Friedberg, E. M. Pickering
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Oncology
ByongYong Yi, Sina Mossahebi, Arezoo Modiri, Elizabeth M. Nichols, Mariana Guerrero, Narottam Lamichhane, Pranshu Mohindra
Summary: This study compared the dosimetric results of volumetric-modulated proton arc therapy (VPAT) with interstitial high-dose-rate (iHDR) brachytherapy for gynecologic cancer patients. The results showed that the HRCTV coverage of VPAT plans was comparable to iHDR plans, but VPAT plans had higher V100% and V90% and D100 values. Additionally, VPAT plans showed advantages in reducing doses to the bladder, rectum, and small bowels.
INTERNATIONAL JOURNAL OF PARTICLE THERAPY
(2022)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
K. Jiang, M. MacFarlane, R. McCarroll, N. Lamichhane, P. Mohindra
Meeting Abstract
Oncology
P. Mohindra, A. Saeed, M. A. L. Vyfhuis, K. Scilla, J. K. Molitoris, C. B. Simone, C. Rolfo, R. Mehra
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)