Radiation induced pulmonary fibrosis as a model of progressive fibrosis: Contributions of DNA damage, inflammatory response and cellular senescence genes

Protective Effects of Myrtol Standardized Against Radiation-Induced Lung Injury

(2016) De-yun Zhao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Targeted Therapy for Idiopathic Pulmonary Fibrosis: Where To Now?

(2016) Sunad Rangarajan et al.   DRUGS

Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis

(2016) Jennifer L. Larson-Casey et al.   IMMUNITY

Immune Inflammation and Disease Progression in Idiopathic Pulmonary Fibrosis

(2016) Elisabetta Balestro et al.   PLoS One

Addressing the Symptoms or Fixing the Problem? Developing Countermeasures against Normal Tissue Radiation Injury

(2016) Jacqueline P. Williams et al.   RADIATION RESEARCH

Ionizing radiation and aging: rejuvenating an old idea

(2016) Richard B. Richardson   Aging-US

Sustained Activation of Toll-Like Receptor 9 Induces an Invasive Phenotype in Lung Fibroblasts

(2015) Varvara Kirillov et al.   AMERICAN JOURNAL OF PATHOLOGY

Blue Journal Conference. Aging and Susceptibility to Lung Disease

(2015) Victor J. Thannickal et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline: Treatment of Idiopathic Pulmonary Fibrosis. An Update of the 2011 Clinical Practice Guideline

(2015) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis

(2015) Sandra Cabrera et al.   Autophagy

Non-targeted effects induced by ionizing radiation: Mechanisms and potential impact on radiation induced health effects

(2015) William F. Morgan et al.   CANCER LETTERS

Effect of glycosides based standardized fenugreek seed extract in bleomycin-induced pulmonary fibrosis in rats: Decisive role of Bax, Nrf2, NF-κB, Muc5ac, TNF-α and IL-1β

(2015) Amit D. Kandhare et al.   CHEMICO-BIOLOGICAL INTERACTIONS

DNA damage at respiratory distress, but not acute time-points, correlates with tissue fibrosis following thoracic radiation exposure in mice

(2015) Amit Kunwar et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

ROS-induced endothelial stress contributes to pulmonary fibrosis through pericytes and Wnt signaling

(2015) Annika Andersson-Sjöland et al.   LABORATORY INVESTIGATION

Creating reference gene annotation for the mouse C57BL6/J genome assembly

(2015) Jonathan M. Mudge et al.   MAMMALIAN GENOME

Bleomycin in the setting of lung fibrosis induction: From biological mechanisms to counteractions

(2015) Veronica Della Latta et al.   PHARMACOLOGICAL RESEARCH

Acute adaptive immune response correlates with late radiation-induced pulmonary fibrosis in mice

(2015) Alexandra Paun et al.   Radiation Oncology

p53/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis

(2015) Wei Wang et al.   Scientific Reports

Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction

(2015) Juan M. Povedano et al.   Cell Reports

Revealing the Pathogenic and Aging-related Mechanisms of the Enigmatic Idiopathic Pulmonary Fibrosis. An Integral Model

(2014) Moisés Selman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Daidzein exhibits anti-fibrotic effect by reducing the expressions of Proteinase activated receptor 2 and TGFβ1/smad mediated inflammation and apoptosis in Bleomycin-induced experimental pulmonary fibrosis

(2014) Syamala Soumyakrishnan et al.   BIOCHIMIE

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Cellular senescence and its effector programs

(2014) R. Salama et al.   GENES & DEVELOPMENT

Grape seed pro-anthocyanidins ameliorates radiation-induced lung injury

(2014) Yijuan Huang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Endogenously Expressed IL-13R 2 Attenuates IL-13-Mediated Responses but Does Not Activate Signaling in Human Lung Fibroblasts

(2014) S. Chandriani et al.   JOURNAL OF IMMUNOLOGY

Idiopathic Pulmonary Fibrosis: From Epithelial Injury to Biomarkers - Insights from the Bench Side

(2014) Keren Borensztajn et al.   RESPIRATION

Telomerase gene mutations and telomere length shortening in patients with idiopathic pulmonary fibrosis in a Chinese population

(2014) Jinghong Dai et al.   RESPIROLOGY

Animal Models of Fibrotic Lung Disease

(2013) Bethany B. Moore et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pathogenesis of Idiopathic Pulmonary Fibrosis

(2013) Paul J. Wolters et al.   Annual Review of Pathology-Mechanisms of Disease

Molecular Mechanisms and Treatment of Radiation-Induced Lung Fibrosis

(2013) Nian-Hua Ding et al.   CURRENT DRUG TARGETS

Senescence-associated secretory phenotype in a mouse model of bleomycin-induced lung injury

(2013) Kazutetsu Aoshiba et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Role of Type II Pneumocyte Senescence in Radiation-Induced Lung Fibrosis

(2013) Deborah E. Citrin et al.   JNCI-Journal of the National Cancer Institute

RefSeq: an update on mammalian reference sequences

(2013) Kim D. Pruitt et al.   NUCLEIC ACIDS RESEARCH

Inhibition of IGF-1R Prevents Ionizing Radiation-Induced Primary Endothelial Cell Senescence

(2013) Ronald Allan M. Panganiban et al.   PLoS One

Berberine attenuates bleomycin induced pulmonary toxicity and fibrosis via suppressing NF-κB dependant TGF-β activation: A biphasic experimental study

(2013) Palanivel Chitra et al.   TOXICOLOGY LETTERS

Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema

(2013) Marco Chilosi et al.   Translational Research

Increased fibroblast telomerase expression precedes myofibroblast α-smooth muscle actin expression in idiopathic pulmonary fibrosis

(2012) DR Waisberg et al.   Clinics

Oxidative Stress Mediates Radiation Lung Injury by Inducing Apoptosis

(2012) Yu Zhang et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

CXC Receptor 1 and 2 and Neutrophil Elastase Inhibitors Alter Radiation-induced Lung Disease in the Mouse

(2012) Jessica Fox et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Differential analysis of gene regulation at transcript resolution with RNA-seq

(2012) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

RNA-Seq analysis in MeV

(2011) E. A. Howe et al.   BIOINFORMATICS

Pulmonary Outcomes in Survivors of Childhood Cancer

(2011) Tseng-Tien Huang et al.   CHEST

Mitochondrial Rac1 GTPase Import and Electron Transfer from CytochromecAre Required for Pulmonary Fibrosis

(2011) Heather L. Osborn-Heaford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44

(2011) Yuejuan Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells

(2010) Shunsuke Minagawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Early Alterations in Cytokine Expression in Adult Compared to Developing Lung in Mice after Radiation Exposure

(2010) Carl J. Johnston et al.   RADIATION RESEARCH

Pathogenetic mechanisms in radiation fibrosis

(2010) John Yarnold et al.   RADIOTHERAPY AND ONCOLOGY

Radiation Pulmonary Toxicity: From Mechanisms to Management

(2010) Paul R. Graves et al.   SEMINARS IN RADIATION ONCOLOGY

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis

(2009) Shubha Murthy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial

(2009) Talmadge E King et al.   LANCET

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Treatment of Idiopathic Pulmonary Fibrosis with Etanercept

(2008) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Antifibrotic action of pirfenidone and prednisolone: Different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis

(2008) Hisashi Oku et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis

(2008) Annika Andersson-Sjöland et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis

(2008) Hong Xia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1

(2008) R. Eferl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative Proteomic Analysis of Radiation-Induced Changes in Mouse Lung: Fibrosis-Sensitive and -Resistant Strains

(2008) Xiaoping Ao et al.   RADIATION RESEARCH

Plasminogen Activation–Induced Pericellular Fibronectin Proteolysis Promotes Fibroblast Apoptosis

(2007) Jeffrey C. Horowitz et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?

(2007) Antje Moeller et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY