Journal
JOURNAL OF RADIATION RESEARCH
Volume 59, Issue -, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jrr/rrx074
Keywords
radiation; unrepairable DSBs; gamma H2AX; senescence; biodosimetry
Funding
- Japanese Ministry of Health, Labour and Welfare (MHLW)
- US Department of Energy (DOE)
- Program of the Network-type (Joint Usage/Research Center for Radiation Disaster Medical Science of Hiroshima University)
- Program of the Network-type (Joint Usage/Research Center for Radiation Disaster Medical Science of Nagasaki University)
- Program of the Network-type (Joint Usage/Research Center for Radiation Disaster Medical Science of Fukushima Medical University)
- Radiation Effects Research Foundation (RERF) [A4-09]
- Japan Society for the Promotion of Science (JSPS) KAKENHI [25550038, 25220102]
- Grants-in-Aid for Scientific Research [25550038] Funding Source: KAKEN
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Although the vast majority of DNA damage induced by radiation exposure disappears rapidly, some lesions remain in the cell nucleus in very small quantities for days to months. These lesions may cause a considerable threat to an organism and include certain types of DNA double-strand breaks (DSBs) called 'unrepairable DSBs'. Unrepairable DSBs are thought to cause persistent malfunctioning of cells and tissues or cause late effects of radiation, especially the induction of delayed cell death, mutation, senescence, or carcinogenesis. Moreover, the measurement of unrepairable DSBs could potentially be used for retrospective biodosimetry or for identifying individuals at greater risk for developing the adverse effects associated with radiotherapy or chemotherapy. This review summarizes the concept of unrepairable DSBs in the context of persistent repair foci formed at DSBs.
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