Cancer Cell Glycocalyx and Its Significance in Cancer Progression

Analytical Pipeline for Discovery and Verification of Glycoproteins from Plasma-Derived Extracellular Vesicles as Breast Cancer Biomarkers

(2018) I-Hsuan Chen et al.   ANALYTICAL CHEMISTRY

Agrin has a pathological role in the progression of oral cancer

(2018) César Rivera et al.   BRITISH JOURNAL OF CANCER

Vascular Cell Glycocalyx-Mediated Vascular Remodeling Induced by Hemodynamic Environmental AlterationNovelty and Significance

(2018) Jiajia Liu et al.   HYPERTENSION

N -glycan signatures identified in tumor interstitial fluid and serum of breast cancer patients: association with tumor biology and clinical outcome

(2018) Thilde Terkelsen et al.   Molecular Oncology

E-selectin-mediated rolling facilitates pancreatic cancer cell adhesion to hyaluronic acid

(2017) Daniel J. Shea et al.   FASEB JOURNAL

Agrin as a Mechanotransduction Signal Regulating YAP through the Hippo Pathway

(2017) Sayan Chakraborty et al.   Cell Reports

A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression

(2017) Elliot C Woods et al.   eLife

Genetically Encoded Toolbox for Glycocalyx Engineering: Tunable Control of Cell Adhesion, Survival, and Cancer Cell Behaviors

(2017) Carolyn R. Shurer et al.   ACS Biomaterials-Science & Engineering

Genetically Encoded Toolbox for Glycocalyx Engineering: Tunable Control of Cell Adhesion, Survival, and Cancer Cell Behaviors

(2017) Carolyn R. Shurer et al.   ACS Biomaterials Science & Engineering

Transcriptional Induction of Periostin by a Sulfatase 2–TGFβ1–SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma

(2016) Gang Chen et al.   CANCER RESEARCH

Heparan sulfate proteoglycans mediate renal carcinoma metastasis

(2016) Henry Qazi et al.   INTERNATIONAL JOURNAL OF CANCER

The glycocalyx and its significance in human medicine

(2016) J. M. Tarbell et al.   JOURNAL OF INTERNAL MEDICINE

Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion

(2015) Piia Takabe et al.   EXPERIMENTAL CELL RESEARCH

Cell surface heparan sulfate proteoglycans control adhesion and invasion of breast carcinoma cells

(2015) Hooi Lim et al.   Molecular Cancer

Sulfatase 2 promotes breast cancer progression through regulating some tumor-related factors

(2015) CHENFANG ZHU et al.   ONCOLOGY REPORTS

An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma

(2015) Sayan Chakraborty et al.   Nature Communications

Syndecan-1-Dependent Suppression of PDK1/Akt/Bad Signaling by Docosahexaenoic Acid Induces Apoptosis in Prostate Cancer

(2015) Yunping Hu et al.   NEOPLASIA

The development of anti-angiogenic heparan sulfate oligosaccharides

(2014) Gordon C. Jayson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy

(2014) Wei Gao et al.   HEPATOLOGY

Shear-induced endothelial NOS activation and remodeling via heparan sulfate, glypican-1, and syndecan-1

(2014) Eno E. Ebong et al.   Integrative Biology

Loss of HSulf-1 expression enhances tumorigenicity by inhibiting Bim expression in ovarian cancer

(2014) Xiaoping He et al.   INTERNATIONAL JOURNAL OF CANCER

Heparanase enhances myeloma progression via CXCL10 downregulation

(2014) U Barash et al.   LEUKEMIA

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

(2014) Matthew J. Paszek et al.   NATURE

Agrin and Perlecan Mediate Tumorigenic Processes in Oral Squamous Cell Carcinoma

(2014) Rebeca Kawahara et al.   PLoS One

Peritumoral interstitial fluid flow velocity predicts survival in cervical carcinoma

(2014) Tord Hompland et al.   RADIOTHERAPY AND ONCOLOGY

The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics

(2014) Edward Hammond et al.   Frontiers in Oncology

Targeted Nanomedicine for Suppression of CD44 and Simultaneous Cell Death Induction in Ovarian Cancer: An Optimal Delivery of siRNA and Anticancer Drug

(2013) V. Shah et al.   CLINICAL CANCER RESEARCH

Targeting syndecans: a promising strategy for the treatment of cancer

(2013) Sojoong Choi et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Enhanced stromal syndecan-1 expression is an independent risk factor for poor survival in bladder cancer

(2013) Tibor Szarvas et al.   HUMAN PATHOLOGY

Cancer cell glycocalyx mediates mechanotransduction and flow-regulated invasion

(2013) Henry Qazi et al.   Integrative Biology

Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion

(2013) Naohiro Takemoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting hyaluronic acid production for the treatment of leukemia: Treatment with 4-methylumbelliferone leads to induction of MAPK-mediated apoptosis in K562 leukemia

(2013) Olga N. Uchakina et al.   LEUKEMIA RESEARCH

Mechano-sensing and transduction by endothelial surface glycocalyx: composition, structure, and function

(2013) Bingmei M. Fu et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Expression of matrix macromolecules and functional properties of breast cancer cells are modulated by the bisphosphonate zoledronic acid

(2012) P.G. Dedes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Effect of the glycocalyx layer on transmission of interstitial flow shear stress to embedded cells

(2012) John M. Tarbell et al.   Biomechanics and Modeling in Mechanobiology

Proteoglycans in stem cells

(2012) Leyla Gasimli et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Glycosaminoglycans: key players in cancer cell biology and treatment

(2012) Nikos Afratis et al.   FEBS Journal

Effect of all-transretinoic acid (ATRA) on syndecan-1 expression and its chemoprotective effect in benzo(α)pyrene-induced lung cancer mice model

(2012) D. Ramya et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

ScFv Anti-Heparan Sulfate Antibodies Unexpectedly Activate Endothelial and Cancer Cells through p38 MAPK: Implications for Antibody-Based Targeting of Heparan Sulfate Proteoglycans in Cancer

(2012) Helena C. Christianson et al.   PLoS One

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

Cytokinetically quiescent (G0/G1) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk1 and MEK1/2

(2011) X.-Y. Pei et al.   BLOOD

HSulf-1 inhibits cell proliferation and invasion in human gastric cancer

(2011) Jie Li et al.   CANCER SCIENCE

Compositional or charge density modification of the endothelial glycocalyx accelerates flow-dependent concentration polarization of low-density lipoproteins

(2011) Hongyan Kang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Control of mucin-type O-glycosylation: A classification of the polypeptide GalNAc-transferase gene family

(2011) E. P. Bennett et al.   GLYCOBIOLOGY

Discoidin domain receptor 2 deficiency predisposes hepatic tissue to colon carcinoma metastasis

(2011) Iker Badiola et al.   GUT

Inhibition of hyaluronan synthesis in breast cancer cells by 4-methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo

(2011) Hiroshi Urakawa et al.   INTERNATIONAL JOURNAL OF CANCER

Role of YKL-40 in the Angiogenesis, Radioresistance, and Progression of Glioblastoma

(2011) Ralph A. Francescone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syndecan-1 promotes the angiogenic phenotype of multiple myeloma endothelial cells

(2011) S Lamorte et al.   LEUKEMIA

Heparan Sulfate Proteoglycans Mediate Interstitial Flow Mechanotransduction Regulating MMP-13 Expression and Cell Motility via FAK-ERK in 3D Collagen

(2011) Zhong-Dong Shi et al.   PLoS One

Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells

(2011) Y.-C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Syndecan-1 antigen, a promising new target for triple-negative breast cancer immuno-PET and radioimmunotherapy. A preclinical study on MDA-MB-468 xenograft tumors

(2011) Caroline Rousseau et al.   EJNMMI Research

Human Sulfatase 2 inhibits in vivo tumor growth of MDA-MB-231 human breast cancer xenografts

(2010) Sarah M Peterson et al.   BMC CANCER

Antitumor Activity of Hyaluronic Acid Synthesis Inhibitor 4-Methylumbelliferone in Prostate Cancer Cells

(2010) Vinata B. Lokeshwar et al.   CANCER RESEARCH

High Wnt Signaling Represses the Proapoptotic Proteoglycan syndecan-2 in Osteosarcoma Cells

(2010) F.-X. Dieudonne et al.   CANCER RESEARCH

Versican induces a pro-metastatic ovarian cancer cell behavior which can be inhibited by small hyaluronan oligosaccharides

(2010) Miranda P. Ween et al.   CLINICAL & EXPERIMENTAL METASTASIS

Antibodies in Single-Chain Format Against Tumour-Associated Antigens:Present and Future Applications

(2010) L. Accardi et al.   CURRENT MEDICINAL CHEMISTRY

Glypican-3: A new target for cancer immunotherapy

(2010) Mitchell Ho et al.   EUROPEAN JOURNAL OF CANCER

The oncogenic effect of sulfatase 2 in human hepatocellular carcinoma is mediated in part by glypican 3-dependent Wnt activation

(2010) Jin-Ping Lai et al.   HEPATOLOGY

Proteoglycomics: Recent Progress and Future Challenges

(2010) Mellisa Ly et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Epac increases melanoma cell migration by a heparan sulfate-related mechanism

(2009) Erdene Baljinnyam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Sialyl-Tn vaccine induces antibody-mediated tumour protection in a relevant murine model

(2009) S Julien et al.   BRITISH JOURNAL OF CANCER

Abrogating Drug Resistance in Malignant Peripheral Nerve Sheath Tumors by Disrupting Hyaluronan-CD44 Interactions with Small Hyaluronan Oligosaccharides

(2009) M. G. Slomiany et al.   CANCER RESEARCH

The Monoclonal Antibody nBT062 Conjugated to Cytotoxic Maytansinoids Has Selective Cytotoxicity Against CD138-Positive Multiple Myeloma Cells In vitro and In vivo

(2009) H. Ikeda et al.   CLINICAL CANCER RESEARCH

4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3

(2009) Anne Kultti et al.   EXPERIMENTAL CELL RESEARCH

Differential expression of α-2,3-sialyltransferases and α-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells

(2009) A.S. Carvalho et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy

(2009) K. Dredge et al.   INVESTIGATIONAL NEW DRUGS

Syndecan-2 Regulates the Migratory Potential of Melanoma Cells

(2009) Jung-hyun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-CD44 induces apoptosis in T lymphoma via mitochondrial depolarization

(2009) Mohini Rajasagi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Syndecan-1 regulates αvβ3and αvβ5integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor

(2009) DeannaLee M. Beauvais et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progression

(2009) Ivan O. Potapenko et al.   Molecular Oncology

Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis

(2009) H Lemjabbar-Alaoui et al.   ONCOGENE

Integrin  1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

(2009) T. Shibue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin Clustering Is Driven by Mechanical Resistance from the Glycocalyx and the Substrate

(2009) Matthew J. Paszek et al.   PLoS Computational Biology

Recombinant CBD–HepII polypeptide of fibronectin inhibits αvβ3 signaling and hematogenous metastasis of tumor

(2008) Wei Gong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-Glypican 3 Antibody as a Potential Antitumor Agent for Human Liver Cancer

(2008) T. Ishiguro et al.   CANCER RESEARCH

CD44 is of Functional Importance for Colorectal Cancer Stem Cells

(2008) L. Du et al.   CLINICAL CANCER RESEARCH

Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma

(2008) Jin-Ping Lai et al.   HEPATOLOGY

Fibroblast growth factor-2 modulates melanoma adhesion and migration through a syndecan-4-dependent mechanism

(2008) Georgia Chalkiadaki et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Heparanase Facilitates Cell Adhesion and Spreading by Clustering of Cell Surface Heparan Sulfate Proteoglycans

(2008) Flonia Levy-Adam et al.   PLoS One

Involvement of CD44, a molecule with a thousand faces, in cancer dissemination

(2008) David Naor et al.   SEMINARS IN CANCER BIOLOGY