Journal
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
Volume 34, Issue 6, Pages 1020-1027Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/08923973.2012.693086
Keywords
Anti-cancer agent; lung cancer; tumor nodule; histopathology; immunohistochemistry
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Funding
- Karunya Univerisity through Karunya Short-Term Research (KSTRG)
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All-trans retinoic acid (ATRA), an active metabolite of retinal, has been shown to exert anti-cancer activities in a number of cancer cells and tissues. Syndecan-1 is a proteoglycan, mediate cell-cell adhesion and prevent invasion in epithelial cells. The aim of the present study was to examine the level of syndecan-1 expression and the chemopreventive effect of ATRA during lung cancer development in BALB/c mice. Syndecan-1 expression was examined by immunohistochemistry using mouse monoclonal anti-human syndecan-1 antibody. In this study, benzo(alpha) pyrene [B(alpha) P] was used to induce lung cancer. The results indicated that ATRA has anti-cancer effect against B(alpha) P-induced lung tumor development as induced by number of tumor nodules and histopathologic report. The loss of syndecan-1 expression in the epithelial cell membrane is associated with tumor cell growth and invasiveness. Our study for syndecan-1 indicated a chemoprotective effect of ATRA against changes in lung epithelial cell membrane syndecan-1 expression in B(alpha) P-induced lung cancer model. Therefore ATRA could serve as effective chemotherapeutic agent against cancer invasion/metastasis, at least in the lungs.
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