Review
Immunology
Partha Jyoti Saikia, Lekhika Pathak, Shirsajit Mitra, Bikul Das
Summary: Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy among the Head and Neck cancer. Recent studies have shown that oral microbiota play a critical role in the initiation and progression of OSCC by activating inflammatory pathways and stemness pathways in cancer cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Zhengrui Li, Yuan Liu, Ling Zhang
Summary: Oral dysbacteriosis and particular microbes may be associated with the occurrence and development of oral cancer.
MICROBIAL PATHOGENESIS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Engku Nasiha Engku Ngah Sayuddin, Muhammad Taher, Mohd Hafiz Arzmi, Nor Aszlitah Burhanudin, Muhamad Ashraf Rostam
Summary: This article reviews the role of podoplanin in oral cancer and its potential as a therapeutic agent. High expression of podoplanin has been observed in oral cancer and pre-cancerous lesions, suggesting that inhibitors targeting podoplanin could be effective in treating oral cancer.
ARCHIVES OF ORAL BIOLOGY
(2024)
Review
Virology
Taketoshi Mizutani, Aya Ishizaka, Michiko Koga, Takeya Tsutsumi, Hiroshi Yotsuyanagi
Summary: Viral infections are influenced by various microorganisms in the environment, and the type and balance of commensal microbiota play a key role in the establishment of infection and pathogenicity. Understanding the interactions among viruses, target tissues, and the surrounding environment, including the commensal microbiota, is crucial for understanding the pathogenesis of viral infections.
Review
Biochemistry & Molecular Biology
Beata Soltesz, Gergely Buglyo, Nikolett Nemeth, Melinda Szilagyi, Ondrej Pos, Tomas Szemes, Istvan Balogh, Balint Nagy
Summary: Extracellular vesicles (EVs) isolated from non-invasively obtained liquid biopsy samples have been found to play a crucial role in early detection and monitoring of cancer. They contribute to intercellular communication and have implications in tumor formation and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
S. S. Prime, N. Cirillo, S. C. Cheong, M. S. Prime, E. K. Parkinson
Summary: This study reviews the molecular landscape of oral potentially malignant disorders, examining the impact of tumour heterogeneity and driver mutations on tumour progression. It proposes monitoring OPMD through liquid biopsies and highlights the identification of functional genes using CRISPR-Cas9 technology as translational implications for drug development.
Review
Oncology
Qianqian Guo, Liwen Li, Shanshan Hou, Ziqiao Yuan, Chenhui Li, Wenzhou Zhang, Lufeng Zheng, Xiaoman Li
Summary: Iron is closely related to the occurrence and development of tumors, playing a crucial role in cell death. Research on iron metabolism disorders and the use of iron in tumor treatment is important for the prevention and treatment of tumors.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Miguel Martin-Perez, Uxue Urdiroz-Urricelqui, Claudia Bigas, Salvador Aznar Benitah
Summary: Lipids play essential roles in the body, but excessive lipids can promote tumor formation and metastasis. Cancer cells utilize lipid metabolism to adapt to the metastatic process and to resist treatment and promote relapse. Metabolic interventions aimed at reducing lipid availability to cancer cells provide promising opportunities for cancer prevention and treatment of metastasis.
Review
Pediatrics
Zheng Jiachen, Tam Paul Kwong Hang, Wong Kenneth Kak Yuen, Lui Vincent Chi Hang
Summary: This paper reviews the metabolism of methionine in normal and abnormal conditions, the potential causes of hypermethioninemia, and its connection to the pathogenesis of biliary atresia.
FRONTIERS IN PEDIATRICS
(2023)
Review
Biochemistry & Molecular Biology
Erika B. Danella, Marcell Costa de Medeiros, Nisha J. D'Silva
Summary: The oral mucosa plays a crucial role in protecting against physical, microbial, and chemical damage. When compromised, the wound healing response is activated, which involves processes such as immune infiltration, re-epithelialization, and stroma remodeling, all controlled by cytokines that promote cellular migration, invasion, and proliferation. These same cytokines are also implicated in cancer dissemination. Therefore, studying the cytokines involved in oral wound healing can provide insights into the cytokines exploited by oral squamous cell carcinoma (SCC) to promote tumor development and progression.
Review
Oncology
Kangkang Ji, Li Li, Hui Liu, Yucheng Shen, Jian Jiang, Minglei Zhang, Hongwei Teng, Xun Yan, Yanhua Zhang, Yong Cai, Hai Zhou
Summary: GAS41, a member of the YEATS domain family, plays a pivotal role in human cancer development as a promising epigenetic reader and a novel oncogene participating in various signaling pathways. Understanding the downstream target oncogenes regulated by GAS41 and developing inhibitors based on its unique recognition properties are crucial in advancing this research field.
CANCER CELL INTERNATIONAL
(2023)
Review
Pharmacology & Pharmacy
Ran Li, Fang Dong, Ling Zhang, Xiuqin Ni, Guozhi Lin
Summary: Obesity is closely linked to endometrial cancer, and adipocytokines secreted by adipose tissue play important roles in the progression of this cancer. Understanding the mechanisms of these adipocytokines may lead to new therapeutic approaches for endometrial cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Wen-Zhao Wang, Jun Li, Lei Liu, Zheng-Dong Zhang, Ming-Xin Li, Qin Li, Hui-Xu Ma, Hai Yang, Xiao-Ling Hou
Summary: Differential expression of circRNA and miRNA after TSCI can play a crucial role in understanding the pathophysiological mechanisms underlying the condition.
NEURAL REGENERATION RESEARCH
(2021)
Article
Oncology
Valeria Manuelli, Fidelma Cahill, Harriet Wylie, Cheryl Gillett, Isabel Correa, Susanne Heck, Alex Rimmer, Anna Haire, Mieke Van Hemelrijck, Sarah Rudman, Claire M. Wells
Summary: This study found that prostate cancer cells have the ability to spontaneously form invadopodia and degrade extracellular matrix, leading to invasion and metastasis in vivo. Circulating tumor cells from patients also exhibited similar characteristics, supporting the role of invadopodia activity in prostate cancer progression.
Review
Biochemistry & Molecular Biology
Yuanyang Wang, Cheng Qin, Gang Yang, Bangbo Zhao, Weibin Wang
Summary: Patients with pancreatic cancer have a poor prognosis due to difficulties in early diagnosis, high metastasis rates, and chemoresistance. Autophagy plays a dual role in cancer development, inhibiting cancer initiation while promoting cancer progression. Inhibiting autophagy can enhance drug efficacy but may also lead to drug resistance in pancreatic cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Dentistry, Oral Surgery & Medicine
Reydson Alcides de Lima-Souza, Joao Figueira Scarini, Luccas Lavareze, Carolina Emerick, Livia Ramalho Crescencio, Romenia Ramos Domingues, Adriana Franco Paes Leme, Bruno Augusto Linhares Almeida Mariz, Debora Campanella Bastos, Renato Assis Machado, Alfio Jose Tincani, Andre Del Negro, Carlos Takahiro Chone, Luiz Paulo Kowalski, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano
Summary: This study analyzed the proteomic profile of salivary pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma (CXPA) samples, and identified seven potential protein signatures that may be associated with the acquisition of a malignant phenotype.
Article
Dentistry, Oral Surgery & Medicine
Marcus Vinicius Ribeiro Carvalho, Carla Isabelly Rodrigues-Fernandes, Cinthia Veronica Bardalez Lopez de Caceres, Ricardo Alves Mesquita, Manoela Domingues Martins, Elena Maria Jose Roman Tager, Roman Carlos, Fabio Ramoa Pires, Liam Robinson, Willie F. P. van Heerden, Vitor Bonetti Valente, Jose Candido Caldeira Xavier-Junior, Daniel Galera Bernabe, Helder Antonio Rebelo Pontes, Ciro Dantas Soares, Mauro Henrique Melo da Costa, Pablo Agustin Vargas, Felipe Paiva Fonseca
Summary: This study investigated the clinicopathologic features of mantle cell lymphoma (MCL) involving the oral and maxillofacial region. The study found that MCL commonly manifests in the oral cavity and oropharynx, with most cases presenting as asymptomatic swellings. The histologic heterogeneity of MCL requires a high degree of diagnostic skill from pathologists.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2023)
Article
Biochemical Research Methods
Flavia S. Zandonadi, Alex Ap. Rosini Silva, Aline A. S. Melo, Raffaela S. Ignarro, Taynara S. Matos, Emerson A. F. Santos, Luidy D. Barbosa, Alexandre L. R. Oliveira, Andreia M. Porcari, Alessandra Sussulini
Summary: Emerging insights from metabolomic studies of major depression disorder (MDD) reveal that energy metabolism, oxidative stress, and neurotransmission are related to MDD. Hub metabolites play a critical role in integrating information flow between metabolism and signaling pathways. This study investigates the effects of ayahuasca (Aya) on cellular metabolism using an in vitro astrocyte model. The results suggest that Aya treatment is associated with changes in branched-chain amino acid metabolism and vitamin B6 and B3 metabolism. Dopamine synthesis is also affected at low concentrations of DMT. Reaction networks containing significant metabolites can guide dose decisions and pathway selection for further studies.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Bianca A. Pauletti, Daniela C. Granato, Carolina M. Carnielli, Guilherme A. Camara, Ana Gabriela C. Normando, Guilherme P. Telles, Adriana F. Paes Leme
Summary: In this study, we developed a practical tool called Typic to assist in the selection of a list of proteotypic peptides for targeted quantitation. Typic integrates input data and downloads additional data to generate output files for each protein, which includes relevant information and auxiliary plots for peptide selection.
JOURNAL OF PROTEOME RESEARCH
(2023)
Letter
Dentistry, Oral Surgery & Medicine
Reydson Alcides de Lima-Souza, Joao Figueira Scarini, Luccas Lavareze, Romenia Ramos Domingues, Adriana Franco Paes Leme, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano
Review
Biochemistry & Molecular Biology
Larissa Tino de Carvalho-Silva, Ana Gabriela C. Normando, Jamile de Oliveira Sa, Erison Santana dos Santos, Tatiane De Rossi, Ariane Fidelis Busso-Lopes, Ana Karina de Oliveira, Adriana F. Paes Leme
Summary: Cancer, a multifactorial disease, is a major cause of death that limits global life expectancy. The development and spread of cancer cells are influenced by the tumor microenvironment (TME), which consists of cancer cells, nonmalignant cells, and an intricate extracellular matrix. Various cell types and their secreted extracellular vesicles (EVs) in the TME, such as cancer-associated fibroblasts (CAFs), T lymphocytes, B cells, tumor-associated macrophages (TAMs), dendritic cells (DC), natural killer (NK) cells, tumor-associated neutrophils (TANs), stem cells, and endothelial cells, play a crucial role in cancer initiation and progression. This review highlights the importance of EVs from different populations of the TME in carcinogenesis.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Natalia G. Blanco, Natalia M. Machado, Ligia L. L. Castro, Mariana A. A. Antunes, Christina M. M. Takiya, Monique R. O. Trugilho, Luana R. R. Silva, Adriana F. Paes F. Leme, Romenia R. Domingues, Bianca A. A. Pauletti, Beatriz T. T. Miranda, Johnatas D. D. Silva, Claudia C. C. dos Santos, Pedro L. L. Silva, Patricia R. M. Rocco, Fernanda F. F. Cruz
Summary: The effects of different sources of MSC-derived extracellular vesicles (EVs), including those obtained from bone marrow (BM), adipose (AD), or lung (L) tissues, on sepsis were investigated. The proteome analysis of EVs revealed that BM-EVs were associated with less organ damage compared with AD-EVs and L-EVs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ciro Dantas Soares, Lucas Lacerda de Souza, Caroline Medeiros Laffitte, Helder Antonio Rebelo Pontes, Oslei Paes de Almeida, Adalberto Mosqueda-Taylor, Juan Carlos Hernandez-Guerrero, Pablo Agustin Vargas, Marcio Ajudarte Lopes, Alan Roger dos Santos-Silva, Alberto da Costa Gurgel, Maira Medeiros de Andrade Pacheco, Alexandre de Oliveira Sales, Carlos Cesar de Oliveira Ramos
Summary: This study found that some patients developed painful tongue lesions related to neural structures after COVID-19 infection, suggesting that symptomatic subgemmal neurogenous plaques (SNP) may be a late manifestation of COVID-19 infection.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Camila Cofre-Leiva, Paola Andrea Camargo-Ayala, Angela Vergara-Perez, Romina Hernandez-Olivos, Sergio Sanhueza, Estefania Nova-Lamperti, Jessica Zuniga-Hernandez, Cesar Rivera
Summary: In this case-crossover study, saliva was found to provide insights on epithelial damage. The downregulation of controlled cell death during the ulcerative phase suggests that endoplasmic reticulum stress may be responsible for the death of oral keratinocytes. Future studies should focus on identifying the mechanism behind the increase in endoplasmic reticulum stress signaling that leads to an anti-cell death response.
Article
Cell Biology
Marisol Miranda-Galvis, Carolina Carneiro Soares, Carolina Moretto Carnielli, Jaqueline Ramalho Buttura, Raisa Sales de Sa, Estela Kaminagakura, Fabio Albuquerque Marchi, Adriana Franco Paes Leme, Clovis A. Lopes Pinto, Alan Roger Santos-Silva, Rogerio Moraes Castilho, Luiz Paulo Kowalski, Cristiane Helena Squarize
Summary: Human papillomavirus (HPV) infection has been linked to a subset of oral cavity cancers, but the molecular mechanisms underlying HPV-driven oral squamous cell carcinoma (OSCC) are not well understood. Proteomics profiling based on the HPV status in OSCC revealed differential abundance of proteins, including COPS3, DYHC1, S100A8, A2M, and Serpine1, which are associated with tumor recurrence, survival, and immune responses. HPV-positive OSCC displayed pathogen-associated pattern receptors, such as S100A8, and activated NF kappa B inflammatory responses. This peculiar microenvironment pattern has important implications for prognosis and treatment decisions.
Article
Biochemistry & Molecular Biology
Alana C. Costa, Larissa B. Rica, Martinus van de Bilt, Flavia S. Zandonadi, Wagner F. Gattaz, Leda L. Talib, Alessandra Sussulini
Summary: In this study, lipidomic profiles of drug-naive patients with schizophrenia (SZ) and bipolar disorder (BD) were compared to healthy controls. Significant alterations in lipid metabolism pathways, especially glycerophospholipids, sphingolipids, and glycerolipids, were observed between SZ and BD patients. These findings provide a basis for differential diagnosis and may contribute to effective treatment and improved quality of life for patients with psychotic disorders.
Article
Pathology
Gabriela Ribeiro de Araujo, Ana Luisa Morais-Perdigao, Cinthia Veronica Bardalez Lopez de Caceres, Marcio Ajudarte Lopes, Jose Manuel Aguirre-Urizar, Roman Carlos, Elena Maria Jose Roman Tager, Willie F. P. van Heerden, Liam Robinson, Helder Antonio Rebelo Pontes, Bruno Augusto Benevenuto de Andrade, Ciro Dantas Soares, Ricardo Santiago Gomez, Felipe Paiva Fonseca
Summary: This study describes the clinicopathological features of a series of lymphomas affecting the sublingual glands, which predominantly include mature B cell lineage and often present as asymptomatic nodules resembling other common lesions in the floor of the mouth such as salivary gland tumors. Among the seven cases identified, follicular lymphoma, diffuse large B cell lymphoma not otherwise specified, extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue, and mantle cell lymphoma were represented.
HEAD & NECK PATHOLOGY
(2023)
Article
Biochemical Research Methods
Bianca A. Pauletti, Daniela C. Granato, Carolina M. Carnielli, Guilherme A. Camara, Ana Gabriela C. Normando, Guilherme P. Telles, Adriana F. Paes Leme
Summary: To address the challenge of selecting suitable proteotypic peptides for targeted quantitative proteomics assays, we have developed an open-source program called Typic. Typic is a practical and semiautomated workflow that combines input data with additional data from public repositories to select a list of proteotypic peptides. The program provides relevant information, a colored ranking of peptides, and auxiliary plots to assist users in the selection process. Overall, Typic allows for a more robust and standardized targeted proteomics assay.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Dermatology
Christiane Rodrigues Tofoli Palauro, Patricia Froes Meyer, Ciro Dantas Soares, Eneida de Morais Carreiro, Flavio de Paiva Dumaresq, Fernando Cesar Camara de Oliveira, Ana Laura Martins de Andrade, Priscila da S. P. S. Daumas
Summary: This study evaluated the effects of a specific technique of cryolipolysis (CLL) application on inflammatory reactions in target tissue. The results showed that there were different inflammatory responses and selective apoptosis at different times after CLL application, with a significant increase in fibroblasts at 45 days and a more pronounced phagocytic action at 60 days.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Review
Pathology
Karen Patricia Dominguez Gallagher, Ana Luiza Oliveira Correa Roza, Elena Maria Jose Roman Tager, Bruno Augusto Linhares Almeida Mariz, Ciro Dantas Soares, Andre Caroli Rocha, Aline Correa Abrahao, Mario Jose Romanach, Roman Carlos, Keith D. Hunter, Marcio Ajudarte Lopes, Pablo Agustin Vargas, Alan Roger Santos-Silva
Summary: Rhabdomyosarcoma (RMS) with EWSR1/FUS-TFCP2 fusions is a rare and aggressive tumor that primarily affects the craniofacial bones, especially the jaws. Understanding its clinicopathologic and immunohistochemical profile can help prevent misdiagnosis.
HEAD & NECK PATHOLOGY
(2023)