Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy

Suppression of Glypican 3 Inhibits Growth of Hepatocellular Carcinoma Cells through Up-Regulation of TGF-β2

(2015) Chris K. Sun et al.   NEOPLASIA

First-in-Man Phase I Study of GC33, a Novel Recombinant Humanized Antibody Against Glypican-3, in Patients with Advanced Hepatocellular Carcinoma

(2013) A. X. Zhu et al.   CLINICAL CANCER RESEARCH

Therapeutically targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinoma

(2013) M. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Points of Therapeutic Intervention Along the Wnt Signaling Pathway in Hepatocellular Carcinoma

(2012) Sarah B. Nambotin et al.   Anti-Cancer Agents in Medicinal Chemistry

Silencing glypican-3 expression induces apoptosis in human hepatocellular carcinoma cells

(2012) Shiyuan Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MiR-219-5p inhibits hepatocellular carcinoma cell proliferation by targeting glypican-3

(2012) Na Huang et al.   FEBS LETTERS

Crystal Structure ofN-Glycosylated Human Glypican-1 Core Protein

(2012) Gabriel Svensson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-affinity monoclonal antibodies to cell surface tumor antigen glypican-3 generated through a combination of peptide immunization and flow cytometry screening

(2012) Yen Phung et al.   mAbs

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

(2012) A. Gurney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Monoclonal Antibodies to Sialyl-Lewisa (CA19.9) with Potent CDC, ADCC, and Antitumor Activity

(2011) R. Sawada et al.   CLINICAL CANCER RESEARCH

Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin

(2011) Wei Wei et al.   Molecular Cancer

M402, a Novel Heparan Sulfate Mimetic, Targets Multiple Pathways Implicated in Tumor Progression and Metastasis

(2011) He Zhou et al.   PLoS One

Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling

(2011) Min-Sung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glypican-3: A new target for cancer immunotherapy

(2010) Mitchell Ho et al.   EUROPEAN JOURNAL OF CANCER

A novel high-affinity human monoclonal antibody to mesothelin

(2010) Mitchell Ho et al.   INTERNATIONAL JOURNAL OF CANCER

Recombinant soluble glypican 3 protein inhibits the growth of hepatocellular carcinoma in vitro

(2010) Mingqian Feng et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

(2010) S. A. Ettenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sulfation of heparan sulfate associated with amyloid-β plaques in patients with Alzheimer’s disease

(2009) Ilona B. Bruinsma et al.   ACTA NEUROPATHOLOGICA

Glypican-3 expression is correlated with poor prognosis in hepatocellular carcinoma

(2009) Hirofumi Shirakawa et al.   CANCER SCIENCE

ScFv Antibody-induced Translocation of Cell-surface Heparan Sulfate Proteoglycan to Endocytic Vesicles

(2009) Anders Wittrup et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blockade of Wnt-1 signaling leads to anti-tumor effects in hepatocellular carcinoma cells

(2009) Wei Wei et al.   Molecular Cancer

Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma

(2008) A Bengochea et al.   BRITISH JOURNAL OF CANCER

Anti-Glypican 3 Antibody as a Potential Antitumor Agent for Human Liver Cancer

(2008) T. Ishiguro et al.   CANCER RESEARCH

PI-88: a novel inhibitor of angiogenesis

(2008) Ragini Kudchadkar et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Glypicans

(2008) Jorge Filmus et al.   GENOME BIOLOGY